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Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation

Published Date:

Feb 18 2016

Publisher's site:

http://dx.doi.org/10.1016/j.stem.2016.01.003 New Site Icon

Source:

Cell Stem Cell. 18(3):410-421.

[PDF-1.52 MB]

Details:

Personal Authors:

Ariyachet, Chaiyaboot ; Tovaglieri, Alessio ; Xiang, Guanjue ; Lu, Jiaqi ; Shah, Manasvi S. ; ... More ▼

Keywords:

[+]

Pubmed ID:

26908146

Pubmed Central ID:

PMC4779391

Description:

The gastrointestinal (GI) epithelium is a highly regenerative tissue with the potential to provide a renewable source of insulin(+) cells after undergoing cellular reprogramming. Here, we show that cells of the antral stomach have a previously unappreciated propensity for conversion into functional insulin-secreting cells. Native antral endocrine cells share a surprising degree of transcriptional similarity with pancreatic β cells, and expression of β cell reprogramming factors in vivo converts antral cells efficiently into insulin(+) cells with close molecular and functional similarity to β cells. Induced GI insulin(+) cells can suppress hyperglycemia in a diabetic mouse model for at least 6 months and regenerate rapidly after ablation. Reprogramming of antral stomach cells assembled into bioengineered mini-organs in vitro yielded transplantable units that also suppressed hyperglycemia in diabetic mice, highlighting the potential for development of engineered stomach tissues as a renewable source of functional β cells for glycemic control.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Main Document Checksum:

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Supporting Files:

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