Acetate mediates a microbiome-brain-β cell axis promoting metabolic syndrome

Perry, Rachel J.; Peng, Liang; Barry, Natasha A.; Cline, Gary W.; Zhang, Dongyan; Cardone, Rebecca L.; Petersen, Kitt Falk; Kibbey, Richard G.; Goodman, Andrew L.; Shulman, Gerald I.

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Acetate mediates a microbiome-brain-β cell axis promoting metabolic syndrome

Published Date:

Jun 09 2016

Source:

Nature. 534(7606):213-217.

Language:

English

[PDF-3.11 MB]

Details:

Alternative Title:

Nature

Personal Author:

Perry, Rachel J. ; Peng, Liang ; Barry, Natasha A. ; Cline, Gary W. ; Zhang, Dongyan ; ... More ▼

Description:

Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae. Together, these findings identify increased acetate production resulting from a nutrient-gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity.

Subject:

[+]

Pubmed ID:

27279214

Pubmed Central ID:

PMC4922538

Document Type:

Journal Article

Funding:

T32 DK101019/DK/NIDDK NIH HHS/United States ; R01 DK-40936/DK/NIDDK NIH HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States ; U24 DK-59635/DK/NIDDK NIH HHS/United States ; R01 GM-103574/GM/NIGMS NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

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