Details:

Alternative Title:
Nature
Personal Author:
Perry, Rachel J. ; Peng, Liang ; Barry, Natasha A. ; Cline, Gary W. ; Zhang, Dongyan ; ... More +
Perry, Rachel J. ; Peng, Liang ; Barry, Natasha A. ; Cline, Gary W. ; Zhang, Dongyan ; Cardone, Rebecca L. ; Petersen, Kitt Falk ; Kibbey, Richard G. ; Goodman, Andrew L. ; Shulman, Gerald I. ; Less -
Description:
Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae. Together, these findings identify increased acetate production resulting from a nutrient-gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity.
Subject:
[+]
Acetates
Animals
Article
Brain
Diet, High-Fat
Gastrointestinal Microbiome
Ghrelin
Glucose
Hyperphagia
Insulin
Insulin-Secreting Cells
Metabolic Syndrome
Obesity
Parasympathetic Nervous System
Rats

Source:
Nature. 534(7606):213-217. ;
Pubmed ID:
27279214
Pubmed Central ID:
PMC4922538
Document Type:
Journal Article ;
Funding:
T32 DK101019/DK/NIDDK NIH HHS/United States ; R01 DK-40936/DK/NIDDK NIH HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States ; U24 DK-59635/DK/NIDDK NIH HHS/United States ; R01 GM-103574/GM/NIGMS NIH HHS/United States ; ... More +
T32 DK101019/DK/NIDDK NIH HHS/United States ; R01 DK-40936/DK/NIDDK NIH HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States ; U24 DK-59635/DK/NIDDK NIH HHS/United States ; R01 GM-103574/GM/NIGMS NIH HHS/United States ; U24 DK059635/DK/NIDDK NIH HHS/United States ; DP2 GM105456/GM/NIGMS NIH HHS/United States ; P30 DK-45735/DK/NIDDK NIH HHS/United States ; R01 DK040936/DK/NIDDK NIH HHS/United States ; DP2 GM-105456/DP/NCCDPHP CDC HHS/United States ; R01 AG023686/AG/NIA NIH HHS/United States ; Howard Hughes Medical Institute/United States ; P30 DK045735/DK/NIDDK NIH HHS/United States ; R01 DK092606/DK/NIDDK NIH HHS/United States ; R01 DK-92606/DK/NIDDK NIH HHS/United States ; T32 DK-101019/DK/NIDDK NIH HHS/United States ; P30 DK034989/DK/NIDDK NIH HHS/United States ; R01 GM103574/GM/NIGMS NIH HHS/United States ; K01 DK089121/DK/NIDDK NIH HHS/United States ; R01 AG-23686/AG/NIA NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:34d6da9e21880484acb6278bef38a4bcd857c5bf5802401c0342d5bb47bad2cc
File Type:

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