Acetate mediates a microbiome-brain-β cell axis promoting metabolic syndrome

Perry, Rachel J.; Peng, Liang; Barry, Natasha A.; Cline, Gary W.; Zhang, Dongyan; Cardone, Rebecca L.; Petersen, Kitt Falk; Kibbey, Richard G.; Goodman, Andrew L.; Shulman, Gerald I.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Acetate mediates a microbiome-brain-β cell axis promoting metabolic syndrome

Published Date:

Jun 09 2016

Source:

Nature. 534(7606):213-217.

Language:

English

[PDF-3.11 MB]

Details:

Alternative Title:

Nature

Personal Author:

Perry, Rachel J. ; Peng, Liang ; Barry, Natasha A. ; Cline, Gary W. ; Zhang, Dongyan ; ... More ▼

Description:

Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae. Together, these findings identify increased acetate production resulting from a nutrient-gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity.

Subject:

[+]

Pubmed ID:

27279214

Pubmed Central ID:

PMC4922538

Document Type:

Journal Article

Funding:

T32 DK101019/DK/NIDDK NIH HHS/United States ; R01 DK-40936/DK/NIDDK NIH HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States ; U24 DK-59635/DK/NIDDK NIH HHS/United States ; R01 GM-103574/GM/NIGMS NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	nihms786451f12.gif	image/gif
	nihms786451f12.jpg	image/jpeg
	nihms786451f13.gif	image/gif
	nihms786451f13.jpg	image/jpeg
	nihms786451f14.gif	image/gif
	nihms786451f14.jpg	image/jpeg
	nihms786451f15.gif	image/gif
	nihms786451f15.jpg	image/jpeg
	nihms786451f16.gif	image/gif
	nihms786451f16.jpg	image/jpeg
	NIHMS786451-supplement-1.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	nihms786451f2.gif	image/gif
	nihms786451f2.jpg	image/jpeg
	nihms786451f3.gif	image/gif
	nihms786451f3.jpg	image/jpeg
	nihms786451f4.gif	image/gif
	nihms786451f4.jpg	image/jpeg
	nihms786451f5.gif	image/gif
	nihms786451f5.jpg	image/jpeg
	nihms786451f6.gif	image/gif
	nihms786451f6.jpg	image/jpeg
	nihms786451.nxml	text/xml
	nihms786451f7.gif	image/gif
	nihms786451f7.jpg	image/jpeg
	nihms786451f8.gif	image/gif
	nihms786451f8.jpg	image/jpeg
	nihms786451f9.gif	image/gif
	nihms786451f9.jpg	image/jpeg
	nihms786451f1.gif	image/gif
	nihms786451f1.jpg	image/jpeg
	nihms786451f10.gif	image/gif
	nihms786451f10.jpg	image/jpeg
	nihms786451f11.gif	image/gif
	nihms786451f11.jpg	image/jpeg

No Related Documents.

You May Also Like:

Gut-Brain Interactions: Implications for a Role of the Gut Microbiota in the Treatment and Prognosis of Anorexia Nervosa

Personal Author:

Igudesman, Daria; Sweeney, Megan; Carroll, Ian; Mayer-Davis, Elizabeth; Bulik, Cynthia M.;

Published Date:

June 25 2019

Source:

Gastroenterol Clin North Am. 48(3):343-356

Description:

Anorexia nervosa has poor prognosis and treatment outcomes and is influenced by genetic, metabolic, and psychological factors. Gut microbes interact with gut physiology to influence metabolism and neurobiology, although potential therapeutic benefits...

Public Access
Available on:

September 01, 2020
A taxonomic signature of obesity in a large study of American adults

Personal Author:

Peters, Brandilyn A.; Shapiro, Jean A.; Church, Timothy R.; Miller, George; Trinh-Shevrin, Chau; Yuen, Elizabeth; Friedlander, Charles; Hayes, Richard B.; Ahn, Jiyoung;

Published Date:

Jun 27 2018

Source:

Sci Rep. 8.

Description:

Animal models suggest that gut microbiota contribute to obesity; however, a consistent taxonomic signature of obesity has yet to be identified in humans. We examined whether a taxonomic signature of obesity is present across two independent study pop...

File Type:

[PDF - 3.90 MB]
Stress-Induced Alterations in Estradiol Sensitivity Increase Risk for Obesity in Women

Personal Author:

Michopoulos, Vasiliki

Published Date:

May 13 2016

Source:

Physiol Behav. 166:56-64

Description:

The prevalence of obesity in the United States continues to rise, increasing individual vulnerability to an array of adverse health outcomes. One factor that has been implicated causally in the increased accumulation of fat and excess food intake is ...

File Type:

[PDF - 481.43 KB]
Role of Nrf2 in Oxidative Stress and Toxicity

Personal Author:

Ma, Qiang

Published Date:

2013

Source:

Annu Rev Pharmacol Toxicol. 53:401-426

Description:

Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are traditionally viewed as being harmful. On the other hand, controlled produc...

File Type:

[PDF - 599.53 KB]
Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy

Personal Author:

Nakamura, Michinari; Liu, Tong; Husain, Seema; Zhai, Peiyong; Warren, Junco S.; Hsu, Chiao-Po; Matsuda, Takahisa; Phiel, Christopher J.; Cox, James E.; Tian, Bin; Li, Hong; Sadoshima, Junichi;

Published Date:

February 07 2019

Source:

Cell Metab. 29(5):1119-1134.e12

Description:

Obesity induces lipotoxic cardiomyopathy, a condition in which lipid accumulation in cardiomyocytes causes cardiac dysfunction. Here, we show that glycogen synthase kinase-3α (GSK-3α) mediates lipid accumulation in the heart. Fatty acids (FAs) upre...

File Type:

[PDF - 3.08 MB]