Acetate mediates a microbiome-brain-β cell axis promoting metabolic syndrome

Details

• Alternative Title:
  Nature
• Personal Author:
  Perry, Rachel J. ; Peng, Liang ; Barry, Natasha A. ; Cline, Gary W. ; Zhang, Dongyan ; Cardone, Rebecca L. ; Petersen, Kitt Falk ; Kibbey, Richard G. ; Goodman, Andrew L. ; Shulman, Gerald I.
• Description:
  Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae. Together, these findings identify increased acetate production resulting from a nutrient-gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity.
• Subjects:
  Acetates Animals Article Brain Diet, High-Fat Gastrointestinal Microbiome Ghrelin Glucose Hyperphagia Insulin Insulin-Secreting Cells Insulin Secretion Metabolic Syndrome Obesity Parasympathetic Nervous System Rats

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• Source:
  Nature. 534(7606):213-217
• Pubmed ID:
  27279214
• Pubmed Central ID:
  PMC4922538
• Document Type:
  Journal Article
• Funding:
  T32 DK101019/DK/NIDDK NIH HHSUnited States/ ; U24 DK-59635/DK/NIDDK NIH HHSUnited States/ ; R01 GM-103574/GM/NIGMS NIH HHSUnited States/ ; U24 DK059635/DK/NIDDK NIH HHSUnited States/ ; DP2 GM105456/GM/NIGMS NIH HHSUnited States/ ; P30 DK-45735/DK/NIDDK NIH HHSUnited States/ ; R01 DK040936/DK/NIDDK NIH HHSUnited States/ ; DP2 GM-105456/DP/NCCDPHP CDC HHSUnited States/ ; R01 AG023686/AG/NIA NIH HHSUnited States/ ; R01 DK-92606/DK/NIDDK NIH HHSUnited States/ ; T32 DK-101019/DK/NIDDK NIH HHSUnited States/ ; P30 DK034989/DK/NIDDK NIH HHSUnited States/ ; R01 GM103574/GM/NIGMS NIH HHSUnited States/ ; K01 DK089121/DK/NIDDK NIH HHSUnited States/ ; R01 DK-40936/DK/NIDDK NIH HHSUnited States/ ; UL1 TR001863/TR/NCATS NIH HHSUnited States/ ; P30 DK045735/DK/NIDDK NIH HHSUnited States/ ; R01 DK092606/DK/NIDDK NIH HHSUnited States/ ; R01 AG-23686/AG/NIA NIH HHSUnited States/ ; HHMI_/Howard Hughes Medical InstituteUnited States/
• Volume:
  534
• Issue:
  7606
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:34d6da9e21880484acb6278bef38a4bcd857c5bf5802401c0342d5bb47bad2cc
• Download URL:
  https://stacks.cdc.gov/view/cdc/40096/cdc_40096_DS1.pdf
• File Type:
  [PDF - 3.11 MB ]