Acetate mediates a microbiome-brain-β cell axis promoting metabolic syndrome

Perry, Rachel J.; Peng, Liang; Barry, Natasha A.; Cline, Gary W.; Zhang, Dongyan; Cardone, Rebecca L.; Petersen, Kitt Falk; Kibbey, Richard G.; Goodman, Andrew L.; Shulman, Gerald I.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Acetate mediates a microbiome-brain-β cell axis promoting metabolic syndrome

Published Date:

Jun 08 2016

Publisher's site:

http://dx.doi.org/ New Site Icon

Source:

Nature. 534(7606):213-217.

[PDF-3.11 MB]

Details:

Personal Authors:

Perry, Rachel J. ; Peng, Liang ; Barry, Natasha A. ; Cline, Gary W. ; Zhang, Dongyan ; ... More ▼

Keywords:

[+]

Pubmed ID:

27279214

Pubmed Central ID:

PMC4922538

Description:

Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae. Together, these findings identify increased acetate production resulting from a nutrient-gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

T32 DK101019/DK/NIDDK NIH HHS/United States
R01 DK-40936/DK/NIDDK NIH HHS/United States
U24 DK-59635/DK/NIDDK NIH HHS/United States
R01 GM-103574/GM/NIGMS NIH HHS/United States
U24 DK059635/DK/NIDDK NIH HHS/United States
DP2 GM105456/GM/NIGMS NIH HHS/United States
P30 DK-45735/DK/NIDDK NIH HHS/United States
R01 DK040936/DK/NIDDK NIH HHS/United States
DP2 GM-105456/DP/NCCDPHP CDC HHS/United States
R01 AG023686/AG/NIA NIH HHS/United States
Howard Hughes Medical Institute/United States
P30 DK045735/DK/NIDDK NIH HHS/United States
R01 DK092606/DK/NIDDK NIH HHS/United States
R01 DK-92606/DK/NIDDK NIH HHS/United States
T32 DK-101019/DK/NIDDK NIH HHS/United States
R01 GM103574/GM/NIGMS NIH HHS/United States
K01 DK089121/DK/NIDDK NIH HHS/United States
R01 AG-23686/AG/NIA NIH HHS/United States

Supporting Files:

	NIHMS786451-supplement-1.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	nihms786451f2.gif	image/gif
	nihms786451f2.jpg	image/jpeg
	nihms786451f3.gif	image/gif
	nihms786451f3.jpg	image/jpeg
	nihms786451f4.gif	image/gif
	nihms786451f4.jpg	image/jpeg
	nihms786451f5.gif	image/gif
	nihms786451f5.jpg	image/jpeg
	nihms786451f6.gif	image/gif
	nihms786451f6.jpg	image/jpeg
	nihms786451.nxml	application/octet-stream
	nihms786451f7.gif	image/gif
	nihms786451f7.jpg	image/jpeg
	nihms786451f8.gif	image/gif
	nihms786451f8.jpg	image/jpeg
	nihms786451f9.gif	image/gif
	nihms786451f9.jpg	image/jpeg
	nihms786451f1.gif	image/gif
	nihms786451f1.jpg	image/jpeg
	nihms786451f10.gif	image/gif
	nihms786451f10.jpg	image/jpeg
	nihms786451f11.gif	image/gif
	nihms786451f11.jpg	image/jpeg

No Related Documents.

You May Also Like:

Role of Nrf2 in Oxidative Stress and Toxicity

Personal Author:

Ma, Qiang

Published:

2013

Source:

Annu Rev Pharmacol Toxicol. 53:401-426.

Description:

Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are traditionally viewed as being harmful. On the other hand, controlled produc...

File Type:

[PDF - 599.53 KB]
Disturbances of sleep and circadian rhythms: Novel risk factors for obesity

Personal Author:

Broussard, Josiane L.; Van Cauter, Eve;

Published:

Oct 2016

Source:

Curr Opin Endocrinol Diabetes Obes. 23(5):353-359.

Description:

Purpose of review : To summarize recent developments linking disturbances of sleep and circadian rhythms to an increased risk for obesity, and to review novel research on potential countermeasures. : Recent findings : Effective treatments for obesity...

File Type:

[PDF - 64.27 KB]
Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

Personal Author:

Ma, Qiang; He, Xiaoqing;

Published:

Sep 10 2012

Source:

Pharmacol Rev. 64(4):1055-1081.

Description:

Induction of drug-metabolizing enzymes through the antioxidant response element (ARE)-dependent transcription was initially implicated in chemoprevention against cancer by antioxidants. Recent progress in understanding the biology and mechanism of in...

File Type:

[PDF - 1.26 MB]
Neural control of sexually dimorphic behaviors

Personal Author:

Manoli, Devanand S; Fan, Pu; Fraser, Eleanor J; Shah, Nirao M;

Published:

May 13 2013

Source:

Curr Opin Neurobiol. 2013; 23(3):330-338.

Description:

All sexually reproducing animals exhibit gender differences in behavior. Such sexual dimorphisms in behavior are most obvious in stereotyped displays that enhance reproductive success such as mating, aggression, and parental care. Sexually dimorphic ...

File Type:

[PDF - 388.50 KB]
MHC Variation Sculpts Individualized Microbial Communities That Control Susceptibility to Enteric Infection

Personal Author:

Kubinak, Jason L.; Stephens, W. Zac; Soto, Ray; Petersen, Charisse; Chiaro, Tyson; Gogokhia, Lasha; Bell, Rickesha; Ajami, Nadim J.; Petrosino, Joseph F.; Morrison, Linda; Potts, Wayne K.; Jensen, Peter E.; O’Connell, Ryan M.; Round, June L.;

Published:

Oct 23 2015

Source:

Nat Commun. 6:8642.

Description:

The presentation of protein antigens on the cell surface by major histocompatibility complex (MHC) molecules coordinates vertebrate adaptive immune responses, thereby mediating susceptibility to a variety of autoimmune and infectious diseases. The co...

File Type:

[PDF - 1.61 MB]