Details:

Alternative Title:
EBioMedicine
Personal Author:
Scinicariello, Franco ; Feroe, Aliya G. ; Attanasio, Roberta
Scinicariello, Franco ; Feroe, Aliya G. ; Attanasio, Roberta Less -
Description:
The International Agency for Research on Cancer classified the di-2-ethylhexyl phthalate (DEHP) as "possibly carcinogenic to humans". In vitro studies reported that phthalate exposure resulted in induction of several nuclear transcription factors that are activators of telomerase reverse transcriptase (TERT) and telomerase activity of the human telomerase complex. The objective of this study was to determine whether there is an association between urinary phthalate metabolites [mono-ethyl phthalate (MEP), mono-butyl phthalate (MBP), mono-(2-ethyl)-hexyl phthalate (MEHP), and mono-benzyl phthalate (MBzP) and leukocyte telomere length (LTL) in the adult population of the National Health and Nutrition Examination Survey (NHANES) 1999-2002 (n=2472). After adjustment for potential confounders, participants in the 3rd and 4th quartiles of urinary MEHP had statistically significantly longer LTL (5.34%, 95% CI: 1.31, 9.53; and 7.14%, 95% CI: 2.94, 11.63; respectively) compared to the lowest quartile, with evidence of a dose-response relationship (p-trend=0.01). The association remained when the analyses were stratified by age groups (20-39years, 40-59years, and 60years and older), and sex. Furthermore, MBP and MBzP were associated with higher LTL in older participants. The age independent association between longer LTL and MEHP (a metabolite of DEHP) might suggest a possible role of MEHP as tumor promoter.
Subjects:
[+]
Leukocyte Telomere Length Mono-(2-ethyl)-hexyl Phthalate NHANES Phthalate Esters: Di-2-ethylhexyl Phthalate Research Paper
Source:
EBioMedicine. 6:96-102.
Pubmed ID:
27211552
Pubmed Central ID:
PMC4856743
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:683615c5e35547db2fb1aa5349b0a7dea0793c7a5ef657603e7ce1cba200fa38
Download URL:
https://stacks.cdc.gov/view/cdc/39755/cdc_39755_DS1.pdf
File Type:

Supporting Files

• 	license.txt	txt
  	main.nxml	bin
  	mmc1.docx	docx

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