Impact of Cotrimoxazole and Insecticide-Treated Nets for Malaria Prevention on Key Outcomes Among HIV-Infected Adults in Low- and Middle-Income Countries: A Systematic Review

Details

• Alternative Title:
  J Acquir Immune Defic Syndr
• Personal Author:
  Hassani, Ahmed Saadani ; Marston, Barbara J.
• Description:
  Background
  
  HIV-infected adults are at increased risk of severe malaria and death. Malaria prevention in people living with HIV (PLHIV) consists of several interventions, including cotrimoxazole (CTX) prophylaxis and insecticide-treated nets (ITNs). We conducted a systematic review of the available evidence.
  
  Methods
  
  MEDLINE, EmBase, Global Health, CINAHL, SOCA, and African Index Medicus were used to identify articles relevant to the CTX prophylaxis and ITNs interventions from 1995 to July 2014. For each individual study, we assessed the quality of evidence and the impact of the 2 interventions on the outcomes of mortality, morbidity, retention in care, quality of life, and/or prevention of ongoing HIV transmission. For each outcome, we summarized the quality of the overall body of evidence, the expected impact, and costing and cost-effectiveness (CE).
  
  Findings
  
  The overall quality of evidence regarding malaria-related morbidity was rated as “good” for CTX prophylaxis and “fair” for ITN use; the expected “impact” of these interventions on morbidity was rated “high” and “uncertain,” respectively. Three studies that addressed the costing and CE of ITN provision for malaria prevention in PLHIV consisted of 2 full “level 1” and 1 partial “level 2” economic evaluations.
  
  Conclusions
  
  CTX prophylaxis is effective in reducing malaria-related morbidity among PLHIV. Limited evidence is available with respect to the impact and the CE of ITN use and/or provision in this population.
  
  
• Subjects:
  Adult Antimalarials Article Cost-Benefit Analysis Cotrimoxazole Developing Countries Health Impact Assessment Health Resources HIV HIV Infections Humans Insecticide-Treated Bednets Insecticide-treated Nets Malaria Malaria Prevention Morbidity Outcome Assessment (Health Care) Quality Of Life Resource-limited Settings Trimethoprim, Sulfamethoxazole Drug Combination

  More +
• Source:
  J Acquir Immune Defic Syndr. 68(Suppl 3):S306-S317
• DOI:
  http://dx.doi.org/10.1097/QAI.0000000000000522
• Pubmed ID:
  25768870
• Pubmed Central ID:
  PMC4818759
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; PEPFAR/United States
• Name as Subject:
  United States. President's Emergency Plan For AIDS Relief (PEPFAR)
• Volume:
  68
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:ed23f7c1ef1528299a39956212e25ef68332596718ad6a737fb73cb74e8e41e57a624725b65e2651ab70dc7c0ac82e8ba767e66438449fbc712bc182082961af
• Download URL:
  https://stacks.cdc.gov/view/cdc/38782/cdc_38782_DS1.pdf
• File Type:
  [PDF - 509.08 KB ]