i
Quantifying Transmission of Clostridium difficile within and outside Healthcare Settings
-
Apr 2016
Source: Emerg Infect Dis. 22(4):608-616. -
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:To quantify the effect of hospital and community-based transmission and control measures on Clostridium difficile infection (CDI), we constructed a transmission model within and between hospital, community, and long-term care-facility settings. By parameterizing the model from national databases and calibrating it to C. difficile prevalence and CDI incidence, we found that hospitalized patients with CDI transmit C. difficile at a rate 15 (95% CI 7.2-32) times that of asymptomatic patients. Long-term care facility residents transmit at a rate of 27% (95% CI 13%-51%) that of hospitalized patients, and persons in the community at a rate of 0.1% (95% CI 0.062%-0.2%) that of hospitalized patients. Despite lower transmission rates for asymptomatic carriers and community sources, these transmission routes have a substantial effect on hospital-onset CDI because of the larger reservoir of hospitalized carriers and persons in the community. Asymptomatic carriers and community sources should be accounted for when designing and evaluating control interventions.
-
Subjects:
-
Source:
-
Pubmed ID:26982504
-
Pubmed Central ID:PMC4806959
-
Document Type:
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
-
pdf bin txt gif jpeg gif jpeg gif jpeg gif jpeg
Details:
Supporting Files
More +