Control of cerebrovascular patterning by neural activity during postnatal development

Lacoste, Baptiste; Gu, Chenghua

doi:10.1016/j.mod.2015.06.003

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Control of cerebrovascular patterning by neural activity during postnatal development

Published Date:

Jun 24 2015

Publisher's site:

http://dx.doi.org/10.1016/j.mod.2015.06.003

Source:

Mech Dev. 138 Pt 1:43-49.

[PDF-359.23 KB]

Details:

Alternative Title:

Mech Dev

Personal Author:

Lacoste, Baptiste ; Gu, Chenghua ;

Description:

The brain represents only a small portion of the body mass and yet consumes almost a quarter of the available energy, and has a limited ability to store energy. The brain is therefore highly dependent on oxygen and nutrient supply from the blood circulation, which makes it vulnerable to vascular pathologies. Key vascular determinants will ensure proper brain maturation and function: the establishment of vascular networks, the formation of the blood-brain barrier, and the regulation of blood flow. Recent evidence suggests that the phenomenon of neurovascular coupling, during which increased neural activity normally leads to increased blood flow, is not functional until few weeks after birth, implying that the developing brain must rely on alternative mechanisms to adequately couple blood supply to increasing energy demands. This review will focus on these alternative mechanisms, which have been partly elucidated recently via the demonstration that neural activity influences the maturation of cerebrovascular networks. We also propose possible mechanisms underlying activity-induced vascular plasticity.

Subject:

[+]

Pubmed ID:

26116138

Pubmed Central ID:

PMC4663105

Document Type:

Journal Article

Funding:

DP1 NS092473/NS/NINDS NIH HHS/United States ; R01 NS064583/NS/NINDS NIH HHS/United States ; DP1 NS092473/DP/NCCDPHP CDC HHS/United States ; R01NS064583/NS/NINDS NIH HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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