Details:

Alternative Title:
Osteoporos Int
Personal Author:
Looker, Anne C.
Description:
Purpose

Dysmobility syndrome was recently proposed as an approach to evaluate the musculoskeletal health of older persons, but data linking this syndrome to adverse outcomes are currently lacking. The present study used data from the National Health and Nutrition Examination Survey (NHANES)1999–2002 to assess the relationship between dysmobility and mortality in adults age 50 and older by age, sex, and race or ethnicity.

Methods

Dysmobility was defined as three or more of the following: high body fat, osteoporosis, low muscle mass, low muscle strength, slow gait speed, or falling risk. Body composition and bone density were assessed with dual energy x-ray absorptiometry. Gait speed was measured via a timed walk, muscle strength via isokinetic knee extension, and fall risk via self-reported balance problems in the past year. Hazards ratios (HR) for mortality were calculated with Cox proportional hazards models.

Results

Twenty-two percent of adults age 50+ years had dysmobility in 1999–2002. Mortality risk by dysmobility varied significantly by age (pinteraction=0.001). HRs for those aged 50–69 years were 3.63 (95% CI 2.69, 4.90) and 2.59 (95% CI 1.82, 3.69), respectively, before and after adjusting for all confounders, compared with 1.46 (95% CI 1.07, 1.99) and 1.23 (95% CI 0.89, 1.69) for those aged 70+ years. The relationship was significant when examined by sex or race/ethnicity within age group for most subgroups.

Conclusions

Dysmobility was associated with increased mortality risk in adults age 50 years and older, with risk being higher in those age 50–69 years than in those age 70+ years.


Subjects:
[+]
Absorptiometry, Photon Aged Aged, 80 And Over Age Distribution Bone Density Female Gait Humans Longitudinal Studies Male Middle Aged Mobility Limitation Muscle Strength Nutrition Surveys Osteoporosis Risk Assessment Syndrome
Source:
Osteoporos Int. 26(1):93-102.
Pubmed ID:
25297891
Pubmed Central ID:
PMC4757903
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Name as Subject:
National Health and Nutrition Examination Survey (U.S.)
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a26b18632cf1fa84daea71dc8c8c2a9ab8a88d4d7e2935f19f6984b7a3667ece
Download URL:
https://stacks.cdc.gov/view/cdc/38081/cdc_38081_DS1.pdf
File Type:

Supporting Files

• 	nihms758504.nxml	bin
  	nihms758504f1.gif	gif
  	nihms758504f1.jpg	jpeg
  	nihms758504f2a.gif	gif
  	nihms758504f2a.jpg	jpeg
  	nihms758504f2b.gif	gif
  	nihms758504f2b.jpg	jpeg

More +