Welcome to CDC stacks |

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Induction of pulmonary fibrosis by cerium oxide nanoparticles

Published Date:

May 18 2012

Publisher's site:

http://dx.doi.org/10.1016/j.taap.2012.05.005

Source:

Toxicol Appl Pharmacol. 262(3):255-264.

[PDF-1.40 MB]

Details:

Alternative Title:

Toxicol Appl Pharmacol

Personal Author:

Ma, Jane Y. ; Mercer, Robert R. ; Barger, Mark ; Schwegler-Berry, Diane ; Scabilloni, James ; ... More ▼

Description:

Cerium compounds have been used as a diesel engine catalyst to lower the mass of diesel exhaust particles, but are emitted as cerium oxide (CeO(2)) nanoparticles in the diesel exhaust. In a previous study, we have demonstrated a wide range of CeO(2)-induced lung responses including sustained pulmonary inflammation and cellular signaling that could lead to pulmonary fibrosis. In this study, we investigated the fibrogenic responses induced by CeO(2) in a rat model at various time points up to 84 days post-exposure. Male Sprague Dawley rats were exposed to CeO(2) by a single intratracheal instillation. Alveolar macrophages (AM) were isolated by bronchial alveolar lavage (BAL). AM-mediated cellular responses, osteopontin (OPN) and transform growth factor (TGF)-β1 in the fibrotic process were investigated. The results showed that CeO(2) exposure significantly increased fibrotic cytokine TGF-β1 and OPN production by AM above controls. The collagen degradation enzymes, matrix metalloproteinase (MMP)-2 and -9 and the tissue inhibitor of MMP were markedly increased in the BAL fluid at 1 day- and subsequently declined at 28 days after exposure, but remained much higher than the controls. CeO(2) induced elevated phospholipids in BAL fluid and increased hydroxyproline content in lung tissue in a dose- and time-dependent manner. Immunohistochemical analysis showed MMP-2, MMP-9 and MMP-10 expressions in fibrotic regions. Morphological analysis noted increased collagen fibers in the lungs exposed to a single dose of 3.5mg/kg CeO(2) and euthanized at 28 days post-exposure. Collectively, our studies show that CeO(2) induced fibrotic lung injury in rats, suggesting it may cause potential health effects.

Subject:

[+]

Pubmed ID:

22613087

Pubmed Central ID:

PMC4697452

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	nihms744216f4.jpg	image/jpeg
	nihms744216f5.gif	image/gif
	nihms744216f5.jpg	image/jpeg
	nihms744216f6.gif	image/gif
	nihms744216f6.jpg	image/jpeg
	nihms744216.nxml	application/octet-stream
	nihms744216f1.gif	image/gif
	nihms744216f1.jpg	image/jpeg
	nihms744216f2.gif	image/gif
	nihms744216f2.jpg	image/jpeg
	nihms744216f3.gif	image/gif
	nihms744216f3.jpg	image/jpeg
	nihms744216f4.gif	image/gif

No Related Documents.

You May Also Like:

State suicide rates among adolescents and young adults aged 10–24 : United States, 2000–2018

Personal Author:

Curtin, Sally C.

Corporate Authors:

National Center for Health Statistics (U.S.). Division of Vital Statistics.

Published Date:

September 11, 2020

Series:

National vital statistics reports ; v. 69, no. 11
DHHS publication ; no. (PHS) 2020–1120

Description:

Objectives—This report presents suicide death rates among persons aged 10–24 for the United States and by state for 2000 through 2018 and percent change between 3-year periods of 2007–2009 and 2016–2018. Suicide rates are compared among state...

File Type:

[PDF - 476.83 KB]
Vital Signs: Characteristics of Drug Overdose Deaths Involving Opioids and Stimulants — 24 States and the District of Columbia, January–June 2019

Personal Author:

O’Donnell, Julie; Gladden, R. Matt; Mattson, Christine L.; Hunter, Calli T.; Davis, Nicole L.;

Published Date:

September 04 2020

Source:

MMWR Morb Mortal Wkly Rep. 69(35):1189-1197

Description:

IntroductionProvisional estimates indicate that drug overdose deaths increased in 2019 after a slight decrease in 2018. In 2018, overdose deaths primarily involved opioids, with continued increases in deaths involving illicitly manufactured fentanyls...

File Type:

[PDF - 262.53 KB]
Seroprevalence of SARS-CoV-2 Among Frontline Health Care Personnel in a Multistate Hospital Network — 13 Academic Medical Centers, April–June 2020

Personal Author:

Self, Wesley H.; Tenforde, Mark W.; Stubblefield, William B.; Feldstein, Leora R.; Steingrub, Jay S.; Shapiro, Nathan I.; Ginde, Adit A.; Prekker, Matthew E.; Brown, Samuel M.; Peltan, Ithan D.; Gong, Michelle N.; Aboodi, Michael S.; Khan, Akram; Exline, Matthew C.; Files, D. Clark; Gibbs, Kevin W.; Lindsell, Christopher J.; Rice, Todd. W.; Jones, Ian D.; Halasa, Natasha; Talbot, H. Keipp; Grijalva, Carlos G.; Casey, Jonathan D.; Hager, David N.; Qadir, Nida; Henning, Daniel J.; Coughlin, Melissa M.; Schiffer, Jarad; Semenova, Vera; Li, Han; Thornburg, Natalie J.; Patel, Manish M.; Baughman, Adrienne; Hart, Kimberly W.; McClellan, Robert; McHenry, Rendie; Johnson, Jakea; Fletcher, Andrea; Rich, Curtis; Cordero, Kemberlyne; Kozikowski, Lori; De Souza, Lesley; Romain, Sarah; Ouellette, Scott; Santana, Andres; Thornton-Thompson, Sherell; Howell, Michelle; Peers, Jennifer; Shelton, Shelby; Finck, Lani; Soules, Kirsten; Klausner, Michael; Calderon-Morales, Ximena; Erickson, Heidi L.; Hendrickson, Audrey; Stang, Jamie; Maruggi, Ellen; Dunn, Alex; Stenehjem, Eddie; Healthcare, Intermountain; Aston, Valerie; Bown, Mikaele; Matheu, Michelle; Smith, Rilee; Krol, Olivia; Salar, Andrew; Health, Oregon; Kamel, Makrina; Health, Oregon; Nguyen, Kelly; Huynh, Peter; Karow, Sarah; Bright, Michelle; Bookless, Holly; Mullins, Sandy; Neidert, Kelly; McGowan, Dina; Cassandra, Elizabeth; Brown, Emily; Carlin, Claire; Wemlinger, Trina; Edwards, Breona; Flores, Lori; LaRose, Mary; Ferbas, Kathie J.; Martin-Blais, Rachel; Aldrovandi, Grace M.; Thompson, Olivia; Sehgal, Sakshi; Ata Ur Rasheed, Mohammed; Mills, Lisa; Lester, Sandra N.; Freeman, Brandi; Alston, Bailey; Ategbole, Muyiwa; Browning, Peter; Cronin, Li; David, Ebenezer; Desai, Rita; Epperson, Monica; Gorantla, Yamini; Jia, Tao; Maniatis, Pete; Ortiz, Kristina; Park, So Hee; Patel, Palak; Qin, Yunlong; Tatum, Heather; Zellner, Briana;

Corporate Authors:

CDC COVID-19 Response Team. IVY Network. IVY Network. CDC COVID-19 Response Team. IVY Network. CDC COVID-19 Response Team.

Published Date:

September 04 2020

Source:

MMWR Morb Mortal Wkly Rep. 69(35):1221-1226

Description:

Health care personnel (HCP) caring for patients with coronavirus disease 2019 (COVID-19) might be at high risk for contracting SARS-CoV-2, the virus that causes COVID-19. Understanding the prevalence of and factors associated with SARS-CoV-2 infectio...

File Type:

[PDF - 131.77 KB]
Nonfatal Occupational Injuries to Younger Workers — United States, 2012–2018

Personal Author:

Guerin, Rebecca J.; Reichard, Audrey A.; Derk, Susan; Hendricks, Kitty J.; Menger-Ogle, Lauren M.; Okun, Andrea H.;

Published Date:

September 04 2020

Source:

MMWR Morb Mortal Wkly Rep. 69(35):1204-1209

Description:

Adolescents and young adults represent approximately 13% of the U.S. workforce (1). Compared with adult workers, young workers (aged 15-24 years) experience higher rates of job-related injury (2,3). To describe injuries among young workers and inform...

File Type:

[PDF - 145.65 KB]
Preventing and Mitigating SARS-CoV-2 Transmission — Four Overnight Camps, Maine, June–August 2020

Personal Author:

Blaisdell, Laura L.; Cohn, Wendy; Pavell, Jeff R.; Rubin, Dana S.; Vergales, Jeffrey E.;

Published Date:

September 04 2020

Source:

MMWR Morb Mortal Wkly Rep. 69(35):1216-1220

Description:

The World Health Organization declared coronavirus disease 2019 (COVID-19) a pandemic on March 11, 2020.* Shortly thereafter, closures of 124,000 U.S. public and private schools affected at least 55.1 million students through the end of the 2019-20 s...

File Type:

[PDF - 138.80 KB]