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Changing plasmid types responsible for extended spectrum cephalosporin resistance in Escherichia coli O157:H7 in the United States, 1996–2009

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  • Alternative Title:
    J Glob Antimicrob Resist
  • Personal Author:
  • Description:
    | O157 is a major cause of foodborne illness. Plasmids are genetic elements that mobilize antimicrobial resistance determinants including|β-lactamases that confer resistance to extended-spectrum cephalosporins (ESC). ESCs are important for treating a variety of infections. IncA/C plasmids are found among diverse sources, including cattle, the principal source of|O157 infections in humans. IncI1 plasmids are common among|and|from poultry and other avian sources. To broaden our understanding of reservoirs of|, we determined the types of plasmids carrying|among|O157. From 1996 to 2009, 3742|O157 isolates were tested. Eleven (0.29%) were ceftriaxone resistant and had a|-containing plasmid. All four isolates submitted before 2001 and a single 2001 isolate had|encoded on IncA/C plasmids, while all five isolates submitted after 2001 and a single 2001 isolate had|carried on IncI1 plasmids. The IncI1 plasmids were ST2, ST20, and ST23. We conclude that cephalosporin resistance among|O157:H7 is due to plasmid-encoded|genes and that plasmid types appear to have shifted from IncA/C to IncI1. This shift suggests either a change in plasmid type among animal reservoirs or that the organism has expanded into avian reservoirs. More analysis of human, retail meat, and food animal isolates is necessary to broaden our understanding of the antimicrobial resistance determinants of ESC resistance among|O157.
  • Subjects:
  • Source:
    J Glob Antimicrob Resist. 2(2):87-91.
  • Pubmed ID:
    26478858
  • Pubmed Central ID:
    PMC4608858
  • Document Type:
    Journal Article
  • Funding:
    CC999999/Intramural CDC HHS/United States
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