Details:

Alternative Title:
Obstet Gynecol
Personal Author:
Kissin, Dmitry M. ; Kulkarni, Aniket D. ; Kushnir, Vitaly A. ; Jamieson, Denise J.
Kissin, Dmitry M. ; Kulkarni, Aniket D. ; Kushnir, Vitaly A. ; Jamieson, Denise J. Less -
Description:
OBJECTIVE

To assess the association between number of embryos transferred and a measure of assisted reproductive technology success that emphasizes good perinatal outcome.

METHODS

We analyzed assisted reproductive technology cycles initiated in 2011 that progressed to fresh embryo transfer among women using autologous oocytes and reported to the U.S. National Assisted Reproductive Technology Surveillance System (n=82,508). Percentages of good perinatal outcome (live birth of a term [at or after 37 weeks of gestation], normal birth weight [2,500 g or greater] singleton) were stratified by prognosis (favorable, average, less favorable), age, embryo stage (day 3, day 5), and number of embryos transferred. Differences in the percentages by number of embryos transferred were evaluated using Fisher’s exact test with Bonferroni correction.

RESULTS

Among patients younger than 35 years with a favorable prognosis, chances of a good perinatal outcome were higher with transferring a single (compared with double) day 5 (43% compared with 27%) or day 3 embryo (36% compared with 30%). Likewise, a higher chance of a good perinatal outcome was observed with transferring a single day 5 embryo in patients 35–37 years old with a favorable prognosis (39% compared with 28%) or patients younger than 35 years old with an average prognosis (35% compared with 26%). A higher chance of good perinatal outcome was associated with transferring two (compared with one) day 3 embryos among patients aged 40 years or younger with an average prognosis or patients younger than 35 years old with a less favorable prognosis.

CONCLUSION

The association between number of embryos transferred and the birth of a term, normal birth weight singleton is described. Among patients younger than 35 years of age undergoing in vitro fertilization with a favorable prognosis, the highest chance of good perinatal outcome is associated with a single embryo transfer.


Keywords:
[+]
Adult Birth Weight Embryo Transfer Female Fertilization In Vitro Gestational Age Humans Infant, Low Birth Weight Live Birth Maternal Age Pregnancy Pregnancy, Multiple Pregnancy Outcome Premature Birth Prognosis Single Embryo Transfer
Source:
Obstet Gynecol. 123(2 0 1):239-247
Pubmed ID:
24402601
Pubmed Central ID:
PMC4607031
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e82d7bcf585bc81f36620d676201dc00a5ae637f0161974b628982809750d8bb
Download URL:
https://stacks.cdc.gov/view/cdc/34982/cdc_34982_DS1.pdf
File Type:

Supporting Files

• 	nihms729012.nxml	xml
  	nihms729012f1.gif	gif
  	nihms729012f1.jpg	jpeg
  	nihms729012f2.gif	gif
  	nihms729012f2.jpg	jpeg
  	nihms729012f3.gif	gif
  	nihms729012f3.jpg	jpeg

More +