Details:

Alternative Title:
Vaccine
Personal Author:
Kahn, Katherine E. ; Santibanez, Tammy A. ; Zhai, Yusheng ; Singleton, James A.
Kahn, Katherine E. ; Santibanez, Tammy A. ; Zhai, Yusheng ; Singleton, James A. Less -
Description:
Background

Influenza vaccines available for children in the United States include inactivated influenza vaccine (IIV) and live, attenuated influenza vaccine (LAIV). Objectives of this study were to quantify proportions of IIV and LAIV received by vaccinated children, and examine associations between vaccine type received and demographic characteristics.

Methods

National Immunization Survey-Flu (NIS-Flu) parental reported data for the 2011-12 through 2013-14 influenza seasons were used to estimate proportions of vaccinated children 2-17 years who received IIV and LAIV. Tests of association between vaccination type and demographic variables were conducted using Wald chi-square tests and pair-wise comparison t-tests. Multivariable logistic regression was used to determine variables independently associated with receipt of LAIV versus IIV.

Results

In the 2013-14 season, 33.3% of vaccinated children received LAIV, similar to the proportion in the 2011-12 (32.2%) and 2012-13 (32.1%) seasons. Across all seasons studied, the strongest observed association was between vaccination type and child's age, with children 2-8 years (Adjusted Prevalence Ratio (95% confidence interval) [APR(95% CI)] 1.41(1.27-1.56), 1.46(1.34-1.59), and 1.50(1.38-1.63) for 2011-12, 2012-13, and 2013-14) and 9-12 years (APR(95% CI) 1.37(1.23-1.54), 1.38(1.26-1.51), and 1.50(1.38-1.63) for 2011-12, 2012-13, and 2013-14) being more likely to have received LAIV than children 13-17 years. Among those vaccinated, whites were more likely to have received LAIV compared to blacks (APR(95% CI) 1.19(1.05-1.35), 1.24(1.10-1.39), and 1.22(1.11-1.34) for 2011-12, 2012-13, and 2013-14), and children living above poverty (annual income >$75,000) were more likely to have received LAIV than those living at or below poverty (APR(95% CI) 1.43(1.23-1.67), 1.13(1.02-1.26), and 1.16(1.06-1.28) for 2011-12, 2012-13, and 2013-14).

Conclusions

This study provides a baseline of the extent and patterns of LAIV uptake that can be used to measure the impact of relevant public health policy. Additional research is needed to investigate parental and provider preferences and barriers regarding LAIV.


Subjects:
[+]
Adolescent Child Child, Preschool Demography Drug Utilization Female Humans Infant Influenza, Human Influenza Vaccines Male United States Vaccines, Attenuated Vaccines, Inactivated
Keywords:
[+]
Health Surveys Influenza Vaccines LAIV Vaccine Vaccination
Source:
Vaccine. 33(39):5196-5203
Pubmed ID:
26238724
Pubmed Central ID:
PMC4597891
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:784ed75fc4774e06f6579e6996b8c101d01b74007e88d1be4ffd886d39bbbcf3
Download URL:
https://stacks.cdc.gov/view/cdc/34853/cdc_34853_DS1.pdf
File Type:

Supporting Files

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