10158954440868JAMA PediatrJAMA PediatrJAMA pediatrics2168-62032168-621125365389458321610.1001/jamapediatrics.2014.1656HHSPA722379ArticleLetter to the Editor JAMA Pediatrics: In Reply to Undertreated and Untreated Pain Should Be Considered an Adverse Event of Neonatal Circumcision, by Sofia Bisogni et al. JAMA Pediatr. 2014;168(11):1076–1077. doi:10.1001/jamapediatrics.2014.1653BcheraouiCharbel ElPhD123DominguezKenneth L.2KilmarxPeter H.MD2Epidemic Intelligence Service, Division of Applied Sciences, Scientific Education and Professional Development Program, Office of Surveillance, Epidemiology and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, GADivision of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GAInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA1492015112014011120151681110771077

We would like to thank Bisogni et al., for their comments about intra- and post-operative pain as an adverse event (AE) to male circumcision (MC). Use of appropriate analgesia for pain management is a good practice that should be the standard of care during and after any surgical procedure as it can substantially control pain1. In a prospective study of 583 neonatal circumcisions performed between December 2005 and December 2008, when appropriate analgesia was applied, 93.5% of neonates circumcised in the first week of life showed no indication of pain on an objective standardized neonatal pain rating system used by the authors2.

The recently published manuscript3 which found a low incidence of adverse events (AEs) (< 0.5%) associated with male circumcision in U.S. medical settings during 2001–2010 is based on data from a healthcare reimbursement claims database. This database captures only diagnoses and procedures billed to third parties. The analysis studied the association between 41 AEs, not including pain, and male circumcision. A search of the same healthcare reimbursement claims database for the ICD9 codes 338.18 (other acute postoperative pain) and 338.19 (other acute pain) detected one patient with pain associated with the male circumcision procedure among 1,400,920 circumcised males. Taking into consideration the possibility that pain may be an underreported AE in the healthcare reimbursement claims database used for this analysis, a more thorough analysis of the association of pain and male circumcision would require additional data sources, including information related to use of and type of pain control methods. As previously recommended3, future researchers studying the association between AEs and male circumcision should consider using additional data sources to ascertain AEs that are not captured in data from reimbursement claims.

PergolizziJV1PappagalloMLeQuangJLabhsetwarSTaylorRNew health care measures: emphasis on better management of postsurgical pain and postoperative nausea and vomitingHosp Pract20144216574(http://www.ncbi.nlm.nih.gov/pubmed/24566598)BanieghbalBOptimal time for neonatal circumcision: an observation-based studyJ Pediatr Urol20095535962(http://www.ncbi.nlm.nih.gov/pubmed/19223238)19223238El BcheraouiCZhangXCooperCSRoseCEKilmarxPHChenRTRates of Adverse Events Associated With Male Circumcision in US Medical Settings, 2001 to 2010JAMA Pediatred online May 12, 2014