Details:

Alternative Title:
Eur J Clin Nutr
Personal Author:
Ford, ES
Description:
OBJECTIVE

To explore the associations between serum concentrations of vitamin D (25(OH)D) and all-cause mortality among US adults defined by lung function (LF) status, particularly among adults with obstructive LF (OLF).

METHODS

Data from 10 795 adults aged 20–79 years (685 with restrictive LF (RLF) and 1309 with OLF) who participated in the Third National Health and Nutrition Examination Survey (1988–1994), had a spirometric examination, and were followed through 2006 were included.

RESULTS

During 14.2 years of follow-up, 1792 participants died. Mean adjusted concentrations of 25(OH)D were 75.0 nmol/l (s.e. 0.7) for adults with normal LF (NLF), 70.4 nmol/l (s.e. 1.8) for adults with RLF, 75.5 nmol/l (s.e. 1.5) for adults with mild obstruction and 71.0 nmol/l (s.e. 1.9) among adults with moderate or worse obstruction (P = 0.030). After adjustment for sociodemographic factors, lifestyle factors, clinical variables and prevalent chronic conditions, a concentration of <25 nmol/l compared with ≥75 nmol//l was associated with mortality only among adults with NLF (hazard ratio (HR) 1.76; 95% confidence interval (CI) 1.03, 3.00). Among participants with OLF, adjusted HRs were 0.65 (95% CI 0.29, 1.48), 1.21 (95% CI 0.89, 1.66) and 0.97 (95% CI 0.78, 1.19) among those with concentrations <25, 25–<50 and 50–<75 nmol/l, respectively.

CONCLUSIONS

Baseline concentrations of 25(OH)D did not significantly predict mortality among US adults with impaired LF.


Keywords:
[+]
Adult Aged Aging Cause Of Death Female Follow-Up Studies Humans Incidence Lung Diseases, Obstructive Male Middle Aged Nutrition Surveys Predictive Value Of Tests Respiratory Function Tests Risk Factors United States Vitamin D Vitamin D Deficiency Young Adult
Source:
Eur J Clin Nutr. 69(5):572-578
Pubmed ID:
25118000
Pubmed Central ID:
PMC4570480
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4115bd9f1fa1e30a863213342c990f358200c85e19601343e1571d87ad17e1e1
Download URL:
https://stacks.cdc.gov/view/cdc/34329/cdc_34329_DS1.pdf
File Type:

Supporting Files

• 	NIHMS718766-supplement-Suppl.xls	xls
  	nihms718766.nxml	xml

More +