Details:

Alternative Title:
Vaccine
Personal Author:
Denniston, Maxine M. ; Klevens, R. Monina ; Jiles, Ruth B. ; Murphy, Trudy V.
Denniston, Maxine M. ; Klevens, R. Monina ; Jiles, Ruth B. ; Murphy, Trudy V. Less -
Description:
Objectives

To estimate the predictive value of self-reported hepatitis A vaccine (HepA) receipt for the presence of hepatitis A virus (HAV) antibody (anti-HAV) from either past infection or vaccination, as an indicator of HAV protection.

Methods

Using 2007–2012 National Health and Nutrition Examination Survey data, we assigned participants to 4 groups based on self-reported HepA receipt and anti-HAV results. We compared characteristics across groups and calculated three measures of agreement between self-report and serologic status (anti- HAV): percentage concordance, and positive (PPV) and negative (NPV) predictive values. Using logistic regression we investigated factors associated with agreement between self-reported vaccination status and serological results.

Results

Demographic and other characteristics varied significantly across the 4 groups. Overall agreement between self-reported HepA receipt and serological results was 63.6% (95% confidence interval [CI] 61.9–65.2); PPV and NPV of self-reported vaccination status for serological result were 47.0% (95% CI 44.2–49.8) and 69.4% (95% CI 67.0–71.8), respectively. Mexican American and foreign-born adults had the highest PPVs (71.5% [95% CI 65.9–76.5], and 75.8% [95% CI 71.4–79.7]) and the lowest NPVs (21.8% [95% CI 18.5–25.4], and 20.0% [95% CI 17.2–23.1]), respectively. Young (ages 20–29 years), US-born, and non-Hispanic White adults had the lowest PPVs (37.9% [95% CI 34.5–41.5], 39.1% [95% CI, 36.0–42.3], and 39.8% [36.1–43.7]), and the highest NPVs (76.9% [95% CI 72.2–81.0, 78.5% [95% CI 76.5–80.4)], and 80.6% [95% CI 78.2–82.8), respectively. Multivariate logistic analyses found age, race/ethnicity, education, place of birth and income to be significantly associated with agreement between self-reported vaccination status and serological results.

Conclusions

When assessing hepatitis A protection, self-report of not having received HepA was most likely to identify persons at risk for hepatitis A infection (no anti-HAV) among young, US-born and non-Hispanic White adults, and self-report of HepA receipt was least likely to be reliable among adults with the same characteristics.


Subjects:
[+]
Adult Aged Aged, 80 And Over Female Hepatitis A Hepatitis A Antibodies Hepatitis A Vaccines Humans Male Middle Aged Nutrition Surveys Self Report United States Young Adult
Keywords:
[+]
Concordance Hepatitis A Vaccine (HepA) Predictive Value Self-report Serological Testing Vaccination Status
Source:
Vaccine. 33(32):3887-3893
Pubmed ID:
26116252
Pubmed Central ID:
PMC4568740
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0e0d91c1d3cf2fb04c7d15959b08061050785ad659cb977353902173088b34de
Download URL:
https://stacks.cdc.gov/view/cdc/34281/cdc_34281_DS1.pdf
File Type:

Supporting Files

• nihms718200.nxml

  xml

More +