Details:

Alternative Title:
BMC Neurol
Personal Author:
Majer, Matthias ; Nater, Urs M ; Lin, Jin-Mann S ; Capuron, Lucile ; Reeves, William C
Majer, Matthias ; Nater, Urs M ; Lin, Jin-Mann S ; Capuron, Lucile ; Reeves, William C Less -
Description:
Background

Animal and human studies suggest that stress experienced early in life has detrimental consequences on brain development, including brain regions involved in cognitive function. Cognitive changes are cardinal features of depression and posttraumatic stress disorder. Early-life trauma is a major risk factor for these disorders. Only few studies have measured the long-term consequences of childhood trauma on cognitive function in healthy adults.

Methods

In this pilot study, we investigated the relationship between childhood trauma exposure and cognitive function in 47 healthy adults, who were identified as part of a larger study from the general population in Wichita, KS. We used the Cambridge Neuropsychological Test Automated Battery (CANTAB) and the Wide-Range-Achievement-Test (WRAT-3) to examine cognitive function and individual achievement. Type and severity of childhood trauma was assessed by the Childhood Trauma Questionnaire (CTQ). Data were analyzed using multiple linear regression on CANTAB measures with primary predictors (CTQ scales) and potential confounders (age, sex, education, income).

Results

Specific CTQ scales were significantly associated with measures of cognitive function. Emotional abuse was associated with impaired spatial working memory performance. Physical neglect correlated with impaired spatial working memory and pattern recognition memory. Sexual abuse and physical neglect were negatively associated with WRAT-3 scores. However, the association did not reach the significance level of p < 0.01.

Conclusions

Our results suggest that physical neglect and emotional abuse might be associated with memory deficits in adulthood, which in turn might pose a risk factor for the development of psychopathology.


Subjects:
[+]
Adult Adult Survivors Of Child Abuse Aged Age Factors Child Child Abuse Child Abuse, Sexual Cognition Educational Status Emotions Female Health Status Humans Income Kansas Male Middle Aged Pilot Projects Sex Factors Violence
Source:
BMC Neurol. 2010; 10:61.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:25adb5de0ca9f993a360f52bf370a073c1d66bd06313f02104c7afb98e506d08
Download URL:
https://stacks.cdc.gov/view/cdc/3415/cdc_3415_DS1.pdf
File Type:

Supporting Files

• 	1471-2377-10-61.nxml	txt
  	license.txt	txt

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