Details:

Journal Article:
MMWR. Morbidity and mortality weekly report
Personal Author:
Marin, Mona ; Bialek, Stephanie R. ; Seward, Jane F.
Marin, Mona ; Bialek, Stephanie R. ; Seward, Jane F. Less -
Corporate Authors:
National Center for Immunization and Respiratory Diseases (U.S.). Division of Viral Diseases.
Description:
In December 2012, the Food and Drug Administration (FDA) approved VariZIG, a varicella zoster immune globulin preparation (Cangene Corporation, Winnipeg, Canada) for use in the United States for postexposure prophylaxis of varicella for persons at high risk for severe disease who lack evidence of immunity to varicella* and for whom varicella vaccine is contraindicated. Previously available under an investigational new drug (IND) expanded access protocol, VariZIG, a purified immune globulin preparation made from human plasma containing high levels of anti-varicella-zoster virus antibodies (immunoglobulin G), is the only varicella zoster immune globulin preparation currently available in the United States. VariZIG is now approved for administration as soon as possible following varicella-zoster virus exposure, ideally within 96 hours (4 days) for greatest effectiveness. CDC recommends administration of VariZIG as soon as possible after exposure to the varicella-zoster virus and within 10 days. CDC also has revised the patient groups recommended by the Advisory Committee on Immunization Practices (ACIP) to receive VariZIG by extending the period of eligibility for previously recommended premature infants from exposures to varicella-zoster virus during the neonatal period to exposures that occur during the entire period for which they require hospital care for their prematurity. The CDC recommendations for VariZIG use are now harmonized with the American Academy of Pediatrics (AAP) recommendations. This report summarizes data on the timing of administration of varicella zoster immune globulin in relation to exposure to varicella-zoster virus and provides the CDC updated recommendations for use of VariZIG that replace the 2007 ACIP recommendations.

Citation: Centers for Disease Control and Prevention (CDC). Updated recommendations for use of VariZIG--United States, 2013. MMWR Morb Mortal Wkly Rep. 2013 Jul 19;62(28):574-6.

PMID: 23863705


Content Notes:
Bauman

8/28/2015


Subjects:
[+]
Chickenpox/prevention & Control Immune Sera/administration & Dosage Immunologic Factors/administration & Dosage Post-Exposure Prophylaxis
Series:
MMWR. Morbidity and mortality weekly report, Vol. 62, no. 28, p. 574-6
Document Type:
Journal Article
Genre:
Practice Guideline
Place as Subject:
United States
Collection(s):
Guidelines and Recommendations
Main Document Checksum:
[+]
urn:sha256:e9d4cbf5ccb78c6947d55de5fe53f032a29722fe57e243509effdc7cd035ce29
Download URL:
https://stacks.cdc.gov/view/cdc/33945/cdc_33945_DS1.pdf
File Type:

Supporting Files

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