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Mid-pregnancy levels of angiogenic markers as indicators of pathways to preterm delivery
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October 24 2011
Source: J Matern Fetal Neonatal Med. 25(7):1135-1141
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Alternative Title:J Matern Fetal Neonatal Med
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Description:Objective
To determine if midpregnancy levels of angiogenic markers were associated with increased risk of preterm delivery (PTD).
Methods
We studied a subcohort from the Pregnancy Outcomes and Community Health Study for whom midpregnancy angiogenic markers [(soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin (sEng), and placental growth factor (PlGF)], and covariate data were available (N = 1301). Angiogenic marker levels were grouped as High/Not High (sFlt-1 & sEng), Low/Not Low (PlGF) and High/Intermediate/Low (sFlt-1). Associations between levels of angiogenic markers and PTD/PTD subtype were determined for women who were non-smokers during pregnancy (N=933).
Results
Low PlGF and High sEng were associated with medically-indicated PTD and PTD <35 weeks, largely due to preeclampsia. Excluding preeclampsia and small-for-gestational-age infants, Low sFlt-1 was positively associated with medically-indicated PTD.
Conclusions
Among non-smokers midpregnancy levels of angiogenic markers may mark multiple pathways leading to PTD, only one attributable to preeclampsia.
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Pubmed ID:21939291
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Pubmed Central ID:PMC4151045
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