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Genetic polymorphisms modify bladder cancer recurrence and survival in a U.S. population-based prognostic study
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2 2015
Source: BJU Int. 115(2):238-247 -
Alternative Title:BJU Int
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Personal Author:
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Description:Objective
To identify genetic variants that modify bladder cancer prognosis focusing on genes involved in major biological carcinogenesis processes (apoptosis, proliferation, DNA repair, hormone regulation, immune surveillance, and cellular metabolism).
Subjects and methods
We analyzed variant genotypes hypothesized to modify these processes in 563 urothelial-cell carcinoma cases enrolled in a population-based study of incident bladder cancer conducted in New Hampshire, U.S.A.
Results
Aldehyde dehydrogenase 2 (ALDH2) variants had shorter time to first bladder cancer recurrence (adjusted non-invasive HR 1.90 95%CI 1.29-2.78).
Conclusion
Our analysis suggests candidate prognostic SNPs that could guide personalized bladder cancer surveillance and treatment.
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Pubmed ID:24666523
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Pubmed Central ID:PMC4533837
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