Emerg Infect DiseidEmerging Infectious Diseases1080-60401080-6059Centers for Disease Control105115272627725Research ArticleAcute Sin Nombre hantavirus infection without pulmonary syndrome, United States.KitsutaniP. T.pdk8@cdc.govDentonR. W.FritzC. L.MurrayR. A.ToddR. L.PapeW. J.Wyatt FramptonJ.YoungJ. C.KhanA. S.PetersC. J.KsiazekT. G.Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.Sep-Oct199955701705

Hantavirus pulmonary syndrome (HPS) occurs in most infections with Sin Nombre virus and other North American hantaviruses. We report five cases of acute hantavirus infection that did not fit the HPS case definition. The patients had characteristic prodromal symptoms without severe pulmonary involvement. These cases suggest that surveillance for HPS may need to be expanded.