Maternal Periconceptional Occupational Pesticide Exposure and Neural Tube Defects
Published Date:Aug 15 2014
Source:Birth Defects Res A Clin Mol Teratol. 100(11):877-886.
Corporate Authors:National Birth Defects Prevention Study
Neural Tube Defects
Prenatal Exposure Delayed Effects
Pubmed Central ID:PMC4523060
Funding:1U01DD001035/DD/NCBDD CDC HHS/United States
200-2000-08018/PHS HHS/United States
5U01DD000492/DD/NCBDD CDC HHS/United States
DK56350/DK/NIDDK NIH HHS/United States
IKE9/Intramural CDC HHS/United States
U01 DD000492/DD/NCBDD CDC HHS/United States
Adverse associations between maternal pesticide exposure and neural tube defects (NTDs) have been suggested but not consistently observed. This study used data from the multisite National Birth Defects Prevention Study to examine associations between maternal periconceptional (1 month preconception through 2 months postconception) occupational pesticide exposure and NTDs.
Mothers of 502 NTD cases and 2950 unaffected live-born control infants with estimated delivery dates from 1997 through 2002 were included. Duration, categorical intensity scores, and categorical frequency scores for pesticide classes (e.g., insecticides) were assigned using a modified, literature-based job-exposure matrix and maternal-reported occupational histories. Adjusted odds ratios (aORs) and 95% confidence intervals were estimated based on fitted multivariable logistic regression models that described associations between maternal periconceptional occupational pesticide exposure and NTDs. The aORs were estimated for pesticide exposure (any [yes/no] and cumulative exposure [intensity × frequency × duration] to any pesticide class, each pesticide class, or combination of pesticide classes) and all NTD cases combined and NTD subtypes.
Positive, but marginally significant or nonsignificant, aORs were observed for exposure to insecticides + herbicides for all NTD cases combined and for spina bifida alone. Similarly, positive aORs were observed for any exposure and cumulative exposure to insecticides + herbicides + fungicides and anencephaly alone and encephalocele alone. All other aORs were near unity.
Pesticide exposure associations varied by NTD subtype and pesticide class. Several aORs were increased, but not significantly. Future work should continue to examine associations between pesticide classes and NTD subtypes using a detailed occupational pesticide exposure assessment and examine pesticide exposures outside the workplace.
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