Determination of a Viral Load Threshold To Distinguish Symptomatic versus Asymptomatic Rotavirus Infection in a High-Disease-Burden African Population

Bennett, A.; Bar-Zeev, N.; Jere, K. C.; Tate, J. E.; Parashar, U. D.; Nakagomi, O.; Heyderman, R. S.; French, N.; Iturriza-Gomara, M.; Cunliffe, N. A.

doi:10.1128/JCM.00875-15

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Determination of a Viral Load Threshold To Distinguish Symptomatic versus Asymptomatic Rotavirus Infection in a High-Disease-Burden African Population

Apr 08 2015
By Bennett, A. ; Bar-Zeev, N. ; Jere, K. C. ; ...
http://dx.doi.org/10.1128/JCM.00875-15
Source: J Clin Microbiol. 2015; 53(6):1951-1954.

[PDF-331.15 KB]

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Details:

Alternative Title:

J Clin Microbiol
Personal Author:

Bennett, A. ; Bar-Zeev, N. ; Jere, K. C. ; Tate, J. E. ; Parashar, U. D. ; ... More +

Bennett, A. ; Bar-Zeev, N. ; Jere, K. C. ; Tate, J. E. ; Parashar, U. D. ; Nakagomi, O. ; Heyderman, R. S. ; French, N. ; Iturriza-Gomara, M. ; Cunliffe, N. A. Less -
Description:

We evaluated quantitative real-time PCR to establish the diagnosis of rotavirus gastroenteritis in a high-disease-burden population in Malawi using enzyme immunoassay as the gold standard diagnostic test. In 146 children with acute gastroenteritis and 65 asymptomatic children, we defined a cutoff point in the threshold cycle value (26.7) that predicts rotavirus-attributable gastroenteritis in this population. These data will inform the evaluation of direct and indirect rotavirus vaccine effects in Africa.
Subjects:

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Virology
Source:

J Clin Microbiol. 2015; 53(6):1951-1954.
Document Type:

Journal Article
Collection(s):

CDC Public Access
Main Document Checksum:

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urn:sha256:de020afa453059150a6018432844367f689a51ab557c44f947ae7fb5c87d936b
Download URL:

https://stacks.cdc.gov/view/cdc/31356/cdc_31356_DS1.pdf
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