Details:

Alternative Title:
J Exp Med
Personal Author:
Lloyd, Clare M. ; Minto, Andrew W. ; Dorf, Martin E. ; Proudfoot, Amanda ; Wells, Timothy N.C. ; ... More +
Lloyd, Clare M. ; Minto, Andrew W. ; Dorf, Martin E. ; Proudfoot, Amanda ; Wells, Timothy N.C. ; Salant, David J. ; Gutierrez-Ramos, Jose-Carlos Less -
Description:
The involvement of chemokines in inflammation is well established, but their functional role in disease progression, and particularly in the development of fibrosis, is not yet understood. To investigate the functional role that the chemokines monocyte chemoattractant protein-1 (MCP-1) and RANTES play in inflammation and the progression to fibrosis during crescentic nephritis we have developed and characterized a murine model for this syndrome. Significant increases in T-lymphocytes and macrophages were observed within glomeruli and interstitium, paralleled by an induction of mRNA expression of MCP-1 and RANTES, early after disease initiation. Blocking the function of MCP-1 or RANTES resulted in significant decreases in proteinuria as well as in numbers of infiltrating leukocytes, indicating that both MCP-1 and RANTES (regulated upon activation in normal T cells expressed and secreted) play an important role in the inflammatory phase of crescentic nephritis. In addition, neutralization of MCP-1 resulted in a dramatic decrease in both glomerular crescent formation and deposition of type I collagen. These results highlight a novel role for MCP-1 in crescent formation and development of interstitial fibrosis, and indicate that in addition to recruiting inflammatory cells this chemokine is critically involved in irreversible tissue damage.
Subjects:
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Animals Chemokine CCL2 Chemokine CCL5 Collagen Disease Models, Animal Disease Progression Fibrosis Glomerulonephritis Immunohistochemistry Kidney Mice Proteinuria RNA, Messenger
Source:
J Exp Med. 1997; 185(7):1371-1380.
Pubmed ID:
9104823
Pubmed Central ID:
PMC2196251
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:d1b2908fb199601e86393144b0aa1bf34a4a6e04a2ce93cd876ceca7a8c73235
Download URL:
https://stacks.cdc.gov/view/cdc/30761/cdc_30761_DS1.pdf
File Type:

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