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Timing of Complementary Food Introduction and Age at Diagnosis of Type 1 Diabetes: the SEARCH Nutrition Ancillary STUDY (SNAS)

Published Date:

Aug 13 2014

Source:

Eur J Clin Nutr. 68(11):1258-1260.

[PDF-118.54 KB]

Details:

Alternative Title:

Eur J Clin Nutr

Personal Author:

Crume, Tessa L. ; Crandell, Jamie ; Norris, Jill M. ; Dabelea, Dana ; Fangman, Mary T. ; ... More ▼

Description:

The association between timing of complementary food introduction and age at diagnosis of type 1 diabetes was investigated among 1077 children in the SEARCH for Diabetes in Youth study. Age at diagnosis was 5 months earlier for children introduced to sugar-sweetened beverages (SSB) in the first 12 months of life compared with those who were not (9.0±0.2 vs 9.5±0.1; P=0.02) independent of human leukocyte antigen (HLA) risk status. Analyses stratified by HLA risk status found that children with a high-risk HLA genotype had an earlier age at diagnosis if they were introduced to fruit juice in the first year of life (mean age at diagnosis=9.3±0.1, 9.1±0.1 and 9.6±0.2 for introduction at ⩽6 months, between 7 and 11 months and ⩾12 months, respectively; P=0.04). Introduction of SSB in the first year of life may accelerate the onset of type 1 diabetes independent of HLA risk status.

Subject:

[+]

Pubmed ID:

25117987

Pubmed Central ID:

PMC4414319

Document Type:

Journal Article

Funding:

00097/PHS HHS/United States ; 1U18DP002709/DP/NCCDPHP CDC HHS/United States ; 1UL1RR026314-01/RR/NCRR NIH HHS/United States ; 200-2010-35171/PHS HHS/United States ; DK056350/DK/NIDDK NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

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Supporting Files:

nihms-599771.nxml

application/octet-stream

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