Case-control analysis of maternal prenatal analgesic use and cardiovascular malformations: Baltimore–Washington Infant Study

Details

• Alternative Title:
  Am J Obstet Gynecol
• Personal Author:
  Marsh, Courtney A. ; Cragan, Janet D. ; Alverson, C. J. ; Correa, Adolfo
• Description:
  OBJECTIVE
  
  We sought to assess maternal prenatal use of analgesics and risk of cardiovascular malformations (CVM) in the offspring.
  
  STUDY DESIGN
  
  Data from the Baltimore–Washington Infant Study, a population-based case-control investigation of CVM, were used to examine selected isolated CVM diagnoses and maternal analgesic use during the periconceptional period (3 months before and after conception). We compared case and control infants on frequency of maternal use of analgesics and estimated adjusted odds ratios (adjORs) and 95% confidence intervals (CI) with logistic regression models for specific CVM phenotypes.
  
  RESULTS
  
  Frequency of periconceptional use of any analgesic was 52% among control mothers and 53% among case mothers. Analyses by CVM diagnoses identified an association of tetralogy of Fallot with maternal acetaminophen use (adjOR, 1.6; 95% CI, 1.1–2.3) and dextrotransposition of the great arteries with intact ventricular septum with maternal nonsteroidal antiinflammatory drug use (adjOR, 3.2; 95% CI, 1.2–8.7).
  
  CONCLUSION
  
  Analgesic use during the periconceptional period was not associated with CVM in the aggregate or with most phenotypes of CVM examined. Associations with 2 phenotypes of CVM may have occurred by chance. These findings warrant corroboration and further study, including further evaluation of the observed associations, the dose of analgesic taken, more specific timing of analgesic use, and indications for use.
  
  
• Subjects:
  Adult Analgesics Article Birth Defects Cardiovascular Abnormalities Cardiovascular Malformations Case-Control Studies Congenital Heart Defects Female Humans Infant, Newborn Interviews As Topic Logistic Models Maternal Exposure Odds Ratio Pregnancy Risk Factors Surveys And Questionnaires

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• Source:
  Am J Obstet Gynecol. 2014; 211(4):404.e1-404.e9.
• Pubmed ID:
  24681289
• Pubmed Central ID:
  PMC4406339
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; R-37 HL25629/HL/NHLBI NIH HHS/United States
• Volume:
  211
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:64b0b6b42cb4bd5ac9f5345a8b6e4ac39a66ff52b170c9a916aba110974c967c
• Download URL:
  https://stacks.cdc.gov/view/cdc/30635/cdc_30635_DS1.pdf
• File Type:
  [PDF - 304.00 KB ]