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Optical Drug Monitoring: Photoacoustic Imaging of Nanosensors to Monitor Therapeutic Lithium In Vivo
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Details:
  • Pubmed ID:
    25588028
  • Pubmed Central ID:
    PMC4364417
  • Description:
    Personalized medicine could revolutionize how primary care physicians treat chronic disease and how researchers study fundamental biological questions. To realize this goal, we need to develop more robust, modular tools and imaging approaches for in vivo monitoring of analytes. In this report, we demonstrate that synthetic nanosensors can measure physiologic parameters with photoacoustic contrast, and we apply that platform to continuously track lithium levels in vivo. Photoacoustic imaging achieves imaging depths that are unattainable with fluorescence or multiphoton microscopy. We validated the photoacoustic results that illustrate the superior imaging depth and quality of photoacoustic imaging with optical measurements. This powerful combination of techniques will unlock the ability to measure analyte changes in deep tissue and will open up photoacoustic imaging as a diagnostic tool for continuous physiological tracking of a wide range of analytes.

  • Document Type:
  • Collection(s):
  • Funding:
    DP1 EB016986/DP/NCCDPHP CDC HHS/United States
    DP1 EB016986/EB/NIBIB NIH HHS/United States
    F32 EB015270/EB/NIBIB NIH HHS/United States
    F32EB015270/EB/NIBIB NIH HHS/United States
    R01 CA157277/CA/NCI NIH HHS/United States
    R01 CA157277/CA/NCI NIH HHS/United States
    R01 CA186567/CA/NCI NIH HHS/United States
    R01 CA186567/CA/NCI NIH HHS/United States
    R01 GM084366/GM/NIGMS NIH HHS/United States
    R01 GM084366/GM/NIGMS NIH HHS/United States
    R01 NS081641/NS/NINDS NIH HHS/United States
    R01 NS081641/NS/NINDS NIH HHS/United States
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