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Manganese Accumulation in Bone Following Chronic Exposure in Rats: Steady-State Concentration and Half-life in Bone

Published Date:

Jun 12 2014

Publisher's site:

http://dx.doi.org/10.1016/j.toxlet.2014.06.019 New Site Icon

Source:

Toxicol Lett. 2014; 229(1):93-100.

[PDF-877.43 KB]

Details:

Alternative Title:

Toxicol Lett

Personal Author:

O’Neal, Stefanie L. ; Hong, Lan ; Fu, Xue ; Jiang, Wendy ; Jones, Alexander ; ... More ▼

Description:

Literature data indicate that bone is a major storage organ for manganese (Mn), accounting for 43% of total body Mn. However, the kinetic nature of Mn in bone, especially the half-life (t(1/2)), remained unknown. This study was designed to understand the time-dependence of Mn distribution in rat bone after chronic oral exposure. Adult male rats received 50 mg Mn/kg (as MnCl2) by oral gavage, 5 days per week, for up to 10 weeks. Animals were sacrificed every 2 weeks during Mn administration for the uptake study, and on day 1, week 2, 4, 8, or 12 after the cessation at 6-week Mn exposure for the t(1/2) study. Mn concentrations in bone (MnBn) were determined by AAS analysis. By the end of 6-week's treatment, MnBn appeared to reach the steady state (T(ss)) level, about 2-3.2 fold higher than MnBn at day 0. Kinetic calculation revealed t(1/2)s of Mn in femur, tibia, and humerus bone of 77 (r=0.978), 263 (r=0.988), and 429 (r=0.994) days, respectively; the average t(1/2) in rat skeleton was about 143 days, equivalent to 8.5 years in human bone. Moreover, MnBn were correlated with Mn levels in striatum, hippocampus, and CSF. These data support MnBn to be a useful biomarker of Mn exposure.

Subject:

[+]

Pubmed ID:

24930841

Pubmed Central ID:

PMC4126163

Document Type:

Journal Article

Funding:

R01 ES008146/ES/NIEHS NIH HHS/United States ; R01-ES008146/ES/NIEHS NIH HHS/United States ; R21-OH010044/OH/NIOSH CDC HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

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Supporting Files:

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