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Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi
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2 15 2013
Source: Org Lett. 15(4):780-783 -
Alternative Title:Org Lett
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Description:Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC(50) of 3 μM, suggestive of a physiological role as an immunosuppressive agent.
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Pubmed ID:23368997
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Pubmed Central ID:PMC3576815
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