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Simultaneous whole-animal 3D-imaging of neuronal activity using light-field microscopy
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May 18 2014
Source: Nat Methods. 11(7):727-730. -
Alternative Title:Nat Methods
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Description:High-speed, large-scale three-dimensional (3D) imaging of neuronal activity poses a major challenge in neuroscience. Here we demonstrate simultaneous functional imaging of neuronal activity at single-neuron resolution in an entire Caenorhabditis elegans and in larval zebrafish brain. Our technique captures the dynamics of spiking neurons in volumes of ∼700 μm × 700 μm × 200 μm at 20 Hz. Its simplicity makes it an attractive tool for high-speed volumetric calcium imaging.
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Pubmed ID:24836920
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Pubmed Central ID:PMC4100252
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