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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="1.3" xml:lang="en" article-type="research-article"><?properties manuscript?><processing-meta base-tagset="archiving" mathml-version="3.0" table-model="xhtml" tagset-family="jats"><restricted-by>pmc</restricted-by></processing-meta><front><journal-meta><journal-id journal-id-type="nlm-journal-id">8709551</journal-id><journal-id journal-id-type="pubmed-jr-id">6252</journal-id><journal-id journal-id-type="nlm-ta">Obstet Gynecol Clin North Am</journal-id><journal-id journal-id-type="iso-abbrev">Obstet Gynecol Clin North Am</journal-id><journal-title-group><journal-title>Obstetrics and gynecology clinics of North America</journal-title></journal-title-group><issn pub-type="ppub">0889-8545</issn><issn pub-type="epub">1558-0474</issn></journal-meta><article-meta><article-id pub-id-type="pmid">41692539</article-id><article-id pub-id-type="pmc">12907543</article-id><article-id pub-id-type="doi">10.1016/j.ogc.2025.09.003</article-id><article-id pub-id-type="manuscript">HHSPA2128910</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Perinatal Quality Collaboratives and Patient Safety Bundles</article-title><subtitle>Key Contributors to Improving Maternal Health Care Quality across the United States</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wallace</surname><given-names>Jacqueline</given-names></name><degrees>MD, MPH</degrees><xref rid="A1" ref-type="aff">a</xref><xref rid="CR1" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Mohamoud</surname><given-names>Yousra A.</given-names></name><degrees>PhD</degrees><xref rid="A1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Guarino</surname><given-names>Allison S.</given-names></name><degrees>MPH</degrees><xref rid="A2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Rohan</surname><given-names>Angela</given-names></name><degrees>PhD</degrees><xref rid="A1" ref-type="aff">a</xref></contrib></contrib-group><aff id="A1"><label>a</label>Maternal and Infant Health Branch, Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA;</aff><aff id="A2"><label>b</label>Department of Non-infectious Disease, CDC Foundation, 600 Peachtree Street NW, #1000, Atlanta, GA 30308, USA</aff><author-notes><corresp id="CR1"><label>*</label>Corresponding author. <email>tsz6@cdc.gov</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>10</day><month>12</month><year>2025</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2026</year></pub-date><pub-date pub-type="epub"><day>01</day><month>12</month><year>2025</year></pub-date><pub-date pub-type="pmc-release"><day>16</day><month>2</month><year>2026</year></pub-date><volume>53</volume><issue>1</issue><fpage>23</fpage><lpage>36</lpage><kwd-group><kwd>Quality improvement</kwd><kwd>Maternal morbidity</kwd><kwd>Maternal mortality</kwd><kwd>Perinatal quality collaboratives</kwd><kwd>Patient safety bundles</kwd></kwd-group></article-meta></front><body><sec id="S1"><title>INTRODUCTION</title><p id="P1">Maternal health outcomes are important measures of the health of a nation.<sup><xref rid="R1" ref-type="bibr">1</xref></sup> In the United States, these outcomes, including morbidity and mortality, are often negative, with significant differences by demographic, geographic, economic and social factors.<sup><xref rid="R2" ref-type="bibr">2</xref>,<xref rid="R3" ref-type="bibr">3</xref></sup> In 2023, the US pregnancy-related mortality ratio was 18.7 deaths per 100,000 live births, continuing a general upward trend since 1987.<sup><xref rid="R3" ref-type="bibr">3</xref></sup> Severe maternal morbidity (SMM) is also high, with approximately 50,000 cases of SMM per year.<sup><xref rid="R1" ref-type="bibr">1</xref></sup> Differences in SMM rates also exist by race/ethnicity, age, geography, income, insurance, disability, and hospital type.<sup><xref rid="R1" ref-type="bibr">1</xref>,<xref rid="R4" ref-type="bibr">4</xref></sup> Although factors contributing to maternal morbidity and mortality are complex, evidence from Maternal Mortality Review Committees (MMRCs) indicates that more than 80% of pregnancy-related deaths are preventable, and almost half of pregnancy-related deaths could be prevented with improvements in care quality at the provider, hospital, and system level.<sup><xref rid="R5" ref-type="bibr">5</xref>&#x02013;<xref rid="R8" ref-type="bibr">8</xref></sup> This makes the quality of health care provided to pregnant women an overarching concern and an important lever for improving outcomes.<sup><xref rid="R5" ref-type="bibr">5</xref>&#x02013;<xref rid="R7" ref-type="bibr">7</xref></sup> This commentary will provide a broad overview of the quality improvement (QI) activities of Perinatal Quality Collaboratives (PQCs) and their use of patient safety bundles (PSBs) to improve maternal health care quality, with the goal of improving maternal health outcomes.</p><sec id="S2"><title>Factors Impacting Maternal Outcomes</title><p id="P2">The increasing prevalence of chronic health conditions in reproductive aged women is an important factor impacting maternal morbidity and mortality.<sup><xref rid="R9" ref-type="bibr">9</xref></sup> Many chronic diseases, such as chronic hypertension and diabetes, can increase the risk of pregnancy complications.<sup><xref rid="R9" ref-type="bibr">9</xref></sup> Between 2005 and 2014, identification of a chronic medical condition at the time of delivery hospitalization increased from 67 per 1000 delivery hospitalizations to 92 per 1000.<sup><xref rid="R9" ref-type="bibr">9</xref></sup> Additionally, in the same time period, substance use disorder in pregnancy, which is linked to poor maternal and neonatal outcomes, increased substantially, particularly among low-income women (from 15.7 to 23.5 per 1000 delivery hospitalizations) and women living in rural locations (from 11.1 to 25.3 per 1000 delivery hospitalizations).<sup><xref rid="R9" ref-type="bibr">9</xref></sup></p><p id="P3">In addition to the impact of increased chronic health conditions and substance use among reproductive aged women, outcomes are also impacted by large variations in obstetric practice,<sup><xref rid="R10" ref-type="bibr">10</xref>&#x02013;<xref rid="R12" ref-type="bibr">12</xref></sup> such as a 10 fold difference in rates of low-risk primary cesarean section in hospitals across the nation.<sup><xref rid="R13" ref-type="bibr">13</xref>,<xref rid="R14" ref-type="bibr">14</xref></sup> While the volume and complexity of patients account for some of the variations in obstetric practice and outcomes across hospitals, a nationwide evaluation of maternal outcomes found that less than 50% of the variation between hospitals could be explained by patient, provider or hospital characteristics.<sup><xref rid="R15" ref-type="bibr">15</xref></sup> The unexplained variation in hospital practices and outcomes indicates other drivers of maternal outcomes may exist, such as variable provider and unit practice patterns.<sup><xref rid="R11" ref-type="bibr">11</xref>,<xref rid="R13" ref-type="bibr">13</xref></sup> This suggests the need for dissemination and implementation of evidence-informed practices and standardized care to improve maternal health care quality and outcomes.<sup><xref rid="R12" ref-type="bibr">12</xref>,<xref rid="R13" ref-type="bibr">13</xref></sup> PQCs are uniquely positioned to support states, hospitals, and their partners in improving the quality of maternal health care.</p></sec></sec><sec id="S3"><title>PERINATAL QUALITY COLLABORATIVES</title><p id="P4">PQCs are state or multistate multidisciplinary teams of nurses, midwives, physicians, QI experts, public health practitioners, patients, and families working to improve the quality of care for mothers and infants.<sup><xref rid="R16" ref-type="bibr">16</xref></sup> PQCs support hospitals in implementing QI activities that increase adoption of evidence-informed practices and help to standardize care.<sup><xref rid="R17" ref-type="bibr">17</xref></sup> Currently, there are maternal and/or infant QI activities occurring in every state in the United States, and a PQC in all 50 states, Washington, DC, and the Defense Health Agency.<sup><xref rid="R18" ref-type="bibr">18</xref></sup> The Centers for Disease Control and Prevention (CDC) has provided funding and technical assistance to PQCs since 2011, growing from an initial cohort of 3 to 36 funded PQCs in 2025. The National Network of PQCs (NNPQC) was formed in 2016, with the support and partnership of March of Dimes, CDC, and perinatal QI experts.<sup><xref rid="R19" ref-type="bibr">19</xref></sup> The NNPQC develops tools and trainings to increase the capacity of all PQCs and provides a national platform for PQCs to collaborate and share best practices, barriers, and successes. The NNPQC continues to receive CDC support and has been coordinated by the National Institute for Children&#x02019;s Health Quality since 2017.<sup><xref rid="R18" ref-type="bibr">18</xref></sup></p><p id="P5">PQCs are uniquely positioned to implement QI activities based on state priorities, emerging maternal and infant health issues, recommendations of MMRCs, and changes in best practices identified by clinical membership organizations.<sup><xref rid="R17" ref-type="bibr">17</xref></sup> Despite differing organizational characteristics, PQCs apply similar methods to identify priority issues and engage hospitals in QI activities. <xref rid="F1" ref-type="fig">Fig. 1</xref> provides a framework to understand the PQC approach to QI activities. While <xref rid="F1" ref-type="fig">Fig. 1</xref> may suggest a linear process, the PQC approach to QI implementation is iterative. Each QI activity builds upon the next, feeding back lessons learned throughout the QI implementation process. Additionally, there are often multiple QI activities at various stages being implemented at the same time.</p><p id="P6">PQC steps to QI implementation are as follows:
<list list-type="simple" id="L2"><list-item><p id="P7">Step 1. Identify priority issues
<list list-type="bullet" id="L4"><list-item><p id="P8">PQCs typically focus on priority issues in their state, frequently working collaboratively with hospitals, QI experts, state health departments, and other partners to identify the most pressing areas in need of improvement.</p></list-item><list-item><p id="P9">PQCs collaborate with their state MMRC, often using data and recommendations from state MMRC reports on the leading causes of maternal deaths to drive their actions.</p></list-item><list-item><p id="P10">The most common topics that PQCs report working on include substance use disorder among pregnant and postpartum women, hypertensive disorders of pregnancy and respectful maternity care and other patient-focused care topics.<sup><xref rid="R18" ref-type="bibr">18</xref></sup></p></list-item></list></p></list-item><list-item><p id="P11">Step 2. Engage hospitals to participate in QI
<list list-type="bullet" id="L6"><list-item><p id="P12">PQCs engage hospitals early and often while developing and implementing QI activities. Hospital teams participate in the selection of QI activities and are key advisors on the development and adaptation of QI resources (eg, toolkits, protocols, and trainings) and provide input and feedback on the implementation of QI activities.</p></list-item><list-item><p id="P13">PQCs support hospitals to form and engage their own QI team, which are multidisciplinary hospital teams who facilitate participation from frontline staff and hospital leadership and drive QI work.</p></list-item></list></p></list-item><list-item><p id="P14">Step 3. Implement QI activities
<list list-type="bullet" id="L8"><list-item><p id="P15">PQCs support hospitals in implementing QI activities to improve patient care, commonly using QI methodology developed by the Institute for Healthcare Improvement (IHI). The IHI Model for Improvement includes defined aims, driver diagrams, measures and activities such as plan-do-study-act cycles to track and evaluate change.<sup><xref rid="R27" ref-type="bibr">27</xref>,<xref rid="R28" ref-type="bibr">28</xref></sup></p></list-item><list-item><p id="P16">Key strategies used by PQCs to support practice change include (1) creating statewide learning collaboratives to share knowledge and strategies to achieve unified statewide improvement, (2) providing rapid-cycle data reports to hospital teams to monitor progress and inform their QI efforts, and (3) providing QI methods support (<xref rid="BX1" ref-type="boxed-text">Box 1</xref>).<sup><xref rid="R17" ref-type="bibr">17</xref>,<xref rid="R27" ref-type="bibr">27</xref></sup></p></list-item></list></p></list-item></list></p></sec><sec id="S4"><title>PATIENT SAFETY BUNDLES</title><p id="P17">The concept of a PSB was first introduced by IHI in 2001 and is defined as &#x0201c;a small set of evidence-based interventions for a defined patient segment/population and care setting that, when implemented together, will result in significantly better outcomes than when implemented individually.&#x0201d;<sup><xref rid="R29" ref-type="bibr">29</xref></sup> PSBs organize recommended clinical practices into a readily implemented package, creating a roadmap that hospitals can follow to redesign care processes and improve care quality. PSBs are an effective approach to improving health care quality and outcomes.<sup><xref rid="R29" ref-type="bibr">29</xref></sup> Maternal PSBs originated in 2012 through the grassroots efforts of 22 obstetric care leaders who recognized the need to improve maternal outcomes in the United States.<sup><xref rid="R30" ref-type="bibr">30</xref></sup> This multidisciplinary effort grew through partnerships with professional and advocacy organizations. Subsequently, with the collaboration of clinical experts, the initial maternal PSBs were developed and published in 2014.<sup><xref rid="R30" ref-type="bibr">30</xref></sup> These efforts were formalized with the creation of the Alliance for Innovation on Maternal Health (AIM), which was founded and is fully funded by the Health Resources and Services Administration (HRSA).<sup><xref rid="R31" ref-type="bibr">31</xref></sup></p><p id="P18">AIM bundles play an important role as population-specific PSBs and offer an evidence-informed, structured way to improve patient care and outcomes.<sup><xref rid="R32" ref-type="bibr">32</xref></sup> AIM PSBs are commonly used by PQCs as the foundation of their QI activities. The AIM Technical Assistance Center, overseen by the American College of Obstetricians and Gynecologists through a cooperative agreement with HRSA, also provides PQCs with PSB support and PSB data collection tools.<sup><xref rid="R33" ref-type="bibr">33</xref></sup> There are currently 8 core PSBs released by AIM, each addressing a specific clinical condition. The AIM PSBs follow a consistent structure, with activities grouped into 5 categories (1) readiness, (2) recognition and prevention, (3) response, (4) reporting and systems learning, and (5) respectful, equitable and supportive care.<sup><xref rid="R32" ref-type="bibr">32</xref></sup>
<xref rid="F1" ref-type="fig">Fig. 1</xref> highlights the role of AIM PSBs within the PQC QI implementation approach.</p><p id="P19">PQCs provide vital infrastructure that brings hospitals across a state together to implement relevant AIM bundles and other PSBs to improve the quality of care. PQCs support collaboration between hospitals and communities, helping to create clinical-community linkages, which support improved care and outcomes.<sup><xref rid="R34" ref-type="bibr">34</xref></sup> Additionally, while the focus of this article is maternal QI activities, PQCs also work to improve neonatal care through QI activities in both neonatal intensive care units and well-baby nurseries. Due to the intersectionality of maternal and neonatal well-being and shared factors affecting the quality of their care,<sup><xref rid="R35" ref-type="bibr">35</xref></sup> PQCs are increasingly implementing QI activities to improve care for the maternal/neonatal dyad.<sup><xref rid="R18" ref-type="bibr">18</xref></sup> In their role as conveners, collaborators and QI experts, PQCs are essential to maternal and infant health improvement efforts and have demonstrated success in improving management and outcomes of priority conditions.</p></sec><sec id="S5"><title>PERINATAL QUALITY COLLABORATIVES&#x02019; IMPACT ON OUTCOMES</title><p id="P20">Highlighted below are some recent examples of how PQCs have improved the quality of maternity care and positively impacted health outcomes using PSBs.</p><sec id="S6"><title>Obstetric Hemorrhage</title><p id="P21">Hemorrhage was the leading cause of pregnancy-related death in 2023,<sup><xref rid="R3" ref-type="bibr">3</xref></sup> and many PQCs have leveraged the <italic toggle="yes">AIM Obstetric Hemorrhage PSB</italic> to improve the management of obstetric hemorrhage.<sup><xref rid="R36" ref-type="bibr">36</xref></sup> PQCs work to improve labor and delivery (L&#x00026;D) unit structure by supporting deployment of hemorrhage carts, which provide ready access to medications and supplies in the event of an obstetric hemorrhage. PQCs also support improved care processes by providing education on hemorrhage risk assessment and measuring quantitative blood loss. The Perinatal-Neonatal Quality Improvement Network of Massachusetts (PNQIN) implemented an obstetric hemorrhage QI initiative from June through November 2021 in 21 of the state&#x02019;s 40 birthing facilities. At the end of the initiative, PNQIN noted the proportion of birthing women who had quantitative blood loss recorded increased from 60% to 80%, and statewide, SMM due to hemorrhage (excluding transfusions) decreased from 618 per 10,000 births to 566 per 10,000 births.<sup><xref rid="R37" ref-type="bibr">37</xref></sup> The West Virginia PQC (West Virginia Perinatal Partnership) implemented an obstetric hemorrhage QI initiative in 2018. At the completion of the initiative, 98% of hospitals had implemented a hemorrhage risk assessment process, 89% of hospitals used quantitative blood loss for blood loss measurement, and SMM due to hemorrhage (excluding transfusions) fell 20% (from 750 per 10,000 births to 600 per 10,000 births).<sup><xref rid="R38" ref-type="bibr">38</xref></sup></p></sec><sec id="S7"><title>Severe Hypertension in Pregnancy</title><p id="P22">Severe hypertension in pregnancy is a leading cause of maternal morbidity and mortality, and early treatment has been shown to reduce SMM for pregnant women with severe hypertension.<sup><xref rid="R3" ref-type="bibr">3</xref>,<xref rid="R39" ref-type="bibr">39</xref></sup> In 2016, the Illinois PQC (ILPQC) began a QI initiative to improve hypertension care across the state, leveraging the <italic toggle="yes">AIM Severe Maternal Hypertension PSB</italic>.<sup><xref rid="R40" ref-type="bibr">40</xref></sup> At the end of the initiative, ILPQC found that the percentage of maternal patients with severe hypertension who received timely treatment (treatment within 1 hour of diagnosis) increased from 56% to 87% across participating hospitals. These gains were seen across the state, and did not differ significantly based on hospital characteristics, suggesting that improvement in outcomes is possible in all hospitals, even those with low volumes or fewer resources.<sup><xref rid="R41" ref-type="bibr">41</xref></sup></p><p id="P23">In Ohio, a coalition of partner organizations, including the Ohio PQC, implemented a QI initiative to improve the management of hypertension in pregnancy in October 2020, adapting the <italic toggle="yes">AIM Severe Maternal Hypertension PSB</italic><sup><xref rid="R40" ref-type="bibr">40</xref></sup> for the Ohio context. The initiative employed typical PQC QI methods, such as monthly calls with all participating hospitals and individual QI coaching. Despite disruptions caused by the coronavirus disease 2019 (COVID-19) pandemic, results indicated an increase in timely treatment of severe hypertension from 56.5% to 67.4% after only 1 year. Participating hospitals spanned all levels of maternal care, and improvement in treatment was seen across all levels, again supporting that all hospitals, regardless of volume, resources or rurality, can improve maternal outcomes through QI activities.<sup><xref rid="R42" ref-type="bibr">42</xref></sup></p></sec><sec id="S8"><title>Safe Reduction of Primary Cesarean Birth</title><p id="P24">The overall rate of cesarean sections has risen substantially in recent decades, increasing from 20.7% in 1996 to 32.1% in 2022.<sup><xref rid="R43" ref-type="bibr">43</xref></sup> While a cesarean section is often a lifesaving procedure, it is also associated with an increased risk of maternal and neonatal morbidity and mortality compared to vaginal birth, and evidence indicates that some cesarean births may not be medically indicated.<sup><xref rid="R44" ref-type="bibr">44</xref>,<xref rid="R45" ref-type="bibr">45</xref></sup> In addition, for those women who undergo a cesarean birth, more than 90% will have subsequent repeat cesarean births, which further increases the risk of morbidity and mortality.<sup><xref rid="R44" ref-type="bibr">44</xref></sup></p><p id="P25">The Maryland PQC implemented an initiative from 2016 to 2018 to reduce cesarean births, utilizing a format based on the IHI model and the <italic toggle="yes">AIM Safe Reduction of Primary Cesarean Births PSB</italic>.<sup><xref rid="R46" ref-type="bibr">46</xref></sup> At the end of the initiative, the rate of nulliparous, term, singleton, vertex (NTSV) cesarean births was reduced from 28.5% to 26.9% across participating hospitals. Notably, greater strength of implementation (measured by the number of practice changes implemented in each individual hospital) was associated with a greater reduction in cesarean births.<sup><xref rid="R23" ref-type="bibr">23</xref></sup></p><p id="P26">The Colorado PQC implemented the Supporting Vaginal Delivery for Low-Risk Mothers initiative in 2019, which aimed to reduce NTSV cesarean births through implementation of a labor dystocia checklist. The initiative included education, regular check-ins, collaborative learning both virtually and in-person, and submitting data to track progress.<sup><xref rid="R47" ref-type="bibr">47</xref></sup> One suburban, medium-volume facility, the site of a family medicine training program, noted that for every 10% increase in labor dystocia checklist completion, there was a 2.1% decrease in the NTSV cesarean rate. An unexpected benefit of the initiative was improved team communication, and the labor dystocia checklist proved to be a valuable teaching tool.<sup><xref rid="R47" ref-type="bibr">47</xref></sup></p></sec><sec id="S9"><title>Substance Use Disorders</title><p id="P27">Mental health conditions are a leading underlying cause of pregnancy-related death in the United States, including deaths by suicide and overdose/poisoning related to substance use disorders (SUDs).<sup><xref rid="R48" ref-type="bibr">48</xref></sup> Between 2010 and 2017, the number of women with opioid-related diagnoses at delivery increased by 131% and Neonatal Abstinence Syndrome increased by 82%.<sup><xref rid="R49" ref-type="bibr">49</xref></sup> Although recommended, SUD screening is often not performed during perinatal health care visits, and when it is, providers may lack knowledge and/or skills to manage SUDs and refer patients to appropriate services.<sup><xref rid="R50" ref-type="bibr">50</xref></sup></p><p id="P28">The Illinois PQC used a learning collaborative approach and the <italic toggle="yes">AIM PSB on Obstetric Care for Women with Opioid Use Disorder</italic><sup><xref rid="R51" ref-type="bibr">51</xref></sup> to implement universal screening for opioid use disorder (OUD) among pregnant women and link those who screened positive for OUD to medication-assisted treatment (MAT), recovery treatment services, and naloxone counseling.<sup><xref rid="R52" ref-type="bibr">52</xref></sup> Linkage to MAT during pregnancy or before delivery discharge increased from 41% to 78% and referral to recovery treatment services was associated with 51% lower odds of preterm birth.<sup><xref rid="R52" ref-type="bibr">52</xref></sup> In addition, the initiative reported reduced differences in linkage to MAT between population subgroups.<sup><xref rid="R52" ref-type="bibr">52</xref></sup> Of note, the current preferred clinical term for medication to treat OUD is medication for opioid use disorder (MOUD).<sup><xref rid="R49" ref-type="bibr">49</xref></sup></p><p id="P29">Through a national learning collaborative, 15 CDC-supported PQCs developed an action plan to address the rise in OUD among pregnant women, identifying the need for provider training to reduce care variation and gaps in comprehensive care and coordination with MOUD.<sup><xref rid="R53" ref-type="bibr">53</xref></sup> Supported by the NNPQC, 12 PQCs in the collaborative worked across their states to increase the number of providers with waivers to prescribe or dispense buprenorphine to treat pregnant and postpartum women, including hosting waiver trainings and encouraging participation in national OUD treatment trainings.<sup><xref rid="R53" ref-type="bibr">53</xref></sup></p></sec></sec><sec id="S10"><title>DISCUSSION</title><p id="P30">PQCs are important statewide networks of teams working across multiple levels (health care systems, hospitals, and providers) to reduce variation in care, increase the adoption of evidence-informed practices, and improve the quality of care for all mothers and infants across the United States. PSBs are essential tools that provide a structured implementation approach to evidence-informed practices and health care quality improvement. PQCs have demonstrated success using PSBs in improving maternal and infant care and outcomes across a wide range of hospitals, including rural and urban, all levels of maternal care, and low- and high-volume hospitals.<sup><xref rid="R41" ref-type="bibr">41</xref>,<xref rid="R42" ref-type="bibr">42</xref></sup> PQCs also demonstrated their resilience by continuing successful QI implementation during the COVID-19 pandemic.<sup><xref rid="R42" ref-type="bibr">42</xref></sup></p><p id="P31">There is a PQC in every state, Washington, DC, and the Defense Health Agency.<sup><xref rid="R18" ref-type="bibr">18</xref></sup> As PQCs mature, they are beginning to expand their activities outside of the hospital, engaging outpatient clinical practices, community health centers, and women with lived experience.<sup><xref rid="R54" ref-type="bibr">54</xref>,<xref rid="R55" ref-type="bibr">55</xref></sup> These growing networks of partners, along with key strategies like collaborative learning and rapid-cycle data processes, make PQCs well positioned to address emerging perinatal health issues. PQCs serve as conveners, able to leverage their networks to bring together a range of partners and act as force multipliers to improve maternal and infant health. Care coordination is an important means to improving outcomes,<sup><xref rid="R34" ref-type="bibr">34</xref>,<xref rid="R56" ref-type="bibr">56</xref>,<xref rid="R57" ref-type="bibr">57</xref></sup> and increased attention is being given nationally to the creation of clinical-community partnerships; for example, new models of care that focus on whole-person care,<sup><xref rid="R58" ref-type="bibr">58</xref></sup> recent QI PSBs created for outpatient settings,<sup><xref rid="R32" ref-type="bibr">32</xref>,<xref rid="R59" ref-type="bibr">59</xref></sup> and a new program that links community-based organizations and hospitals.<sup><xref rid="R60" ref-type="bibr">60</xref></sup> Like these national efforts, PQCs are also supporting the creation of strong clinical-community linkages through collaborations with a wide range of partners.</p><p id="P32">In addition to varied partners, the multidisciplinary nature of most PQC teams is also key to their success. Made up of nurses, midwives, physicians, QI experts, public health practitioners, patients and families, PQCs benefit from the knowledge, skills, and perspectives of these various groups. Support from hospital-level providers is also essential for PQCs&#x02019; success. There are multiple ways providers can contribute to PQC efforts (<xref rid="BX2" ref-type="boxed-text">Box 2</xref>), with the first step being to identify their state PQC on the NNPQC interactive map of PQCs.<sup><xref rid="R18" ref-type="bibr">18</xref></sup> Second, providers can learn about ongoing statewide QI efforts by visiting their state PQC Web site and reviewing the data reports and resources available. Third, providers can actively engage with their state PQC. Attending PQC sponsored education events is one simple way to participate and often comes with the benefit of continuing education credit. Obstetric clinician champions are essential to successful QI implementation by encouraging the interest of their peers and supporting changes in the culture of the L&#x00026;D unit.<sup><xref rid="R17" ref-type="bibr">17</xref></sup> Difficulties in recruiting clinical champions is the most common barrier reported by hospital teams striving to implement QI activities.<sup><xref rid="R17" ref-type="bibr">17</xref></sup> In addition to clinical champions, PQCs often rely on obstetric clinicians to fill leadership positions, helping to bridge the gap among QI specialists, public health practitioners, and clinical boots on the ground.<sup><xref rid="R17" ref-type="bibr">17</xref></sup> Finally, endorsing QI efforts to hospital leadership and educating providers in their networks are other important ways obstetric clinicians can support their state PQC.<sup><xref rid="R17" ref-type="bibr">17</xref></sup></p></sec><sec id="S11"><title>SUMMARY</title><p id="P33">PQCs are composed of implementation experts working to reduce variation in care and increase the adoption of evidence-informed practices through implementation of PSBs and other QI activities. PQCs serve as conveners, bringing broad partners together and moving data on maternal and infant health outcomes to action. By standardizing clinical care, streamlining workflows, and developing and measuring improved processes and protocols for care, PQCs are reducing errors and improving health outcomes.<sup><xref rid="R61" ref-type="bibr">61</xref></sup> Many PQCs have demonstrated measurable improvements to maternal health outcomes through quality improvement initiatives.<sup><xref rid="R23" ref-type="bibr">23</xref>,<xref rid="R37" ref-type="bibr">37</xref>,<xref rid="R38" ref-type="bibr">38</xref>,<xref rid="R41" ref-type="bibr">41</xref>,<xref rid="R42" ref-type="bibr">42</xref>,<xref rid="R47" ref-type="bibr">47</xref>,<xref rid="R52" ref-type="bibr">52</xref>,<xref rid="R53" ref-type="bibr">53</xref></sup></p><p id="P34">The expansion of PQC activities to settings outside of the hospital may help address the complex social factors that impact maternal morbidity and mortality. For example, care coordination is an important strategy to improve outcomes.<sup><xref rid="R34" ref-type="bibr">34</xref>,<xref rid="R56" ref-type="bibr">56</xref>,<xref rid="R57" ref-type="bibr">57</xref></sup> Many PQCs are working to improve care coordination, such as connecting pregnant and postpartum women to needed social services.<sup><xref rid="R62" ref-type="bibr">62</xref>,<xref rid="R63" ref-type="bibr">63</xref></sup> Through partnerships with clinicians, public health advocates, communities and women with lived experience, PQCs are uniquely positioned to connect broad partners to work together to improve maternal and infant health outcomes across the Unites States, improving outcomes for all mothers and their babies.</p></sec></body><back><ack id="S12"><title>ACKNOWLEDGMENTS</title><p id="P35">The authors are thankful for the support of Tiffany Colarusso, MD, MPH and Charlan Kroelinger, PhD of the Maternal and Infant Health Branch, Division of Reproductive Health, within the National Center for Chronic Disease Prevention and Health Promotion of the CDC. The authors recognize and appreciate the work of all state PQC teams and providers and staff in facilities participating with their state PQC.</p></ack><fn-group><fn id="FN1"><p id="P36">DISCLAIMER</p><p id="P37">The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention (CDC).</p></fn><fn fn-type="COI-statement" id="FN2"><p id="P38">DISCLOSURE</p><p id="P39">The authors have no conflicts of interest to disclose.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term>AIM</term><def><p id="P40">Alliance for Innovation on Maternal Health</p></def></def-item><def-item><term>CDC</term><def><p id="P41">Centers for Disease Control and Prevention</p></def></def-item><def-item><term>COVID-19</term><def><p id="P42">coronavirus disease 2019</p></def></def-item><def-item><term>HRSA</term><def><p id="P43">Health Resources and Services Administration</p></def></def-item><def-item><term>IHI</term><def><p id="P44">Institute for Healthcare Improvement</p></def></def-item><def-item><term>ILPQC</term><def><p id="P45">Illinois PQC</p></def></def-item><def-item><term>L&#x00026;D</term><def><p id="P46">labor and delivery</p></def></def-item><def-item><term>MAT</term><def><p id="P47">medication-assisted treatment</p></def></def-item><def-item><term>MMRCs</term><def><p id="P48">Maternal Mortality Review Committees</p></def></def-item><def-item><term>MOUD</term><def><p id="P49">medication for opioid use disorder</p></def></def-item><def-item><term>NNPQC</term><def><p id="P50">National Network of PQCs</p></def></def-item><def-item><term>NTSV</term><def><p id="P51">nulliparous, term, singleton, vertex</p></def></def-item><def-item><term>OUD</term><def><p id="P52">opioid use disorder</p></def></def-item><def-item><term>PNQIN</term><def><p id="P53">Perinatal-Neonatal Quality Improvement Network of Massachusetts</p></def></def-item><def-item><term>PQCs</term><def><p id="P54">Perinatal Quality Collaboratives</p></def></def-item><def-item><term>PSB</term><def><p id="P55">patient safety bundle</p></def></def-item><def-item><term>QI</term><def><p id="P56">quality improvement</p></def></def-item><def-item><term>SMM</term><def><p id="P57">severe maternal morbidity</p></def></def-item><def-item><term>SUDs</term><def><p id="P58">substance use disorders</p></def></def-item><def-item><term>TA</term><def><p id="P59">technical assistance</p></def></def-item></def-list></glossary><ref-list><title>REFERENCES</title><ref id="R1"><label>1.</label><mixed-citation publication-type="journal"><name><surname>Declerq</surname><given-names>EZL</given-names></name>. <article-title>Severe maternal morbidity in the United States: a primer</article-title>. <source>The commonwealth fund</source>. <year>2021</year>. 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Available at: <ext-link xlink:href="https://uabsoph.maps.arcgis.com/apps/MapJournal/index.html?appid=d6fca1b6b56f44f4be7924761893af45" ext-link-type="uri">https://uabsoph.maps.arcgis.com/apps/MapJournal/index.html?appid=d6fca1b6b56f44f4be7924761893af45</ext-link>. Accessed <date-in-citation>June 5, 2025</date-in-citation>.</mixed-citation></ref></ref-list></back><floats-group><fig position="float" id="F1"><label>Fig. 1.</label><caption><p id="P60">Perinatal Quality Collaboratives&#x02019; (PQC) Approach to Quality Improvement (QI) implementation and the role of Patient Safety Bundles (PSBs). PQCs, Perinatal Quality Collaboratives; MMRC, Maternal Mortality Review Committees; PSB(s), Patient Safety Bundles(s); QI, quality improvement; AIM, Alliance for Innovation on Maternal Health. <sup>a</sup>Details of key PQC strategies to implement Q1 can be found in <xref rid="BX1" ref-type="boxed-text">Box 1</xref>.</p></caption><graphic xlink:href="nihms-2128910-f0001" position="float"/></fig><boxed-text id="BX1" position="float"><label>Box 1</label><caption><title>Key Perinatal Quality Collaborative strategies to implement quality improvement</title></caption><sec id="S13"><title>Collaborative Learning</title><p id="P61">PQCs provide opportunities for hospital teams to learn collaboratively by hosting regular virtual meetings, providing mechanisms for ad hoc information sharing, such as state-specific online portals, and through periodic in-person meetings. These sessions are a critical point of support for hospital teams, providing opportunities for teams to discuss common barriers and brainstorm solutions, allowing for widespread dissemination of best practices and strategies to improve QI implementation. Many PQCs develop and conduct webinar series on clinical topics, such as harm reduction, hepatitis C screening and treatment, and perinatal mental health conditions.<sup><xref rid="R20" ref-type="bibr">20</xref></sup> Some PQCs offer training opportunities that are less topic specific and more implementation specific, such as example clinical protocols and education on QI methods.<sup><xref rid="R21" ref-type="bibr">21</xref>,<xref rid="R22" ref-type="bibr">22</xref></sup> Regularly scheduled webinars over a series of months ensure continuous learning and multiple opportunities to reinforce concepts, test for understanding, and maintain an engaged network of providers and partners. Conference calls and in-person meetings with facilitated discussions allow for information sharing and useful instruction.<sup><xref rid="R23" ref-type="bibr">23</xref>,<xref rid="R24" ref-type="bibr">24</xref></sup></p></sec><sec id="S14"><title>Rapid-cycle Data Reporting</title><p id="P62">Another integral element of PQCs is providing rapid-cycle data reports to hospital teams. Regardless of the QI methodology used, QI entails implementation of small tests of change, ongoing data collection to monitor those changes and reporting of data to track results. PQCs provide much needed assistance to hospital teams by supporting data collection and analysis, compiling the data and then sharing back timely, accurate data with the hospital teams to track results.</p></sec><sec id="S15"><title>QI Methods Support</title><p id="P63">Hospitals have differing capacities to implement QI, and PQCs provide individualized QI technical assistance (TA) and resources to support implementation of QI activities. Most PQCs have dedicated QI coaches that meet regularly with hospital teams to provide ongoing education and hospital-specific TA. Through guidance from advisory groups and TA calls, PQCs provide support, keeping implementation consistent and of high quality.<sup><xref rid="R20" ref-type="bibr">20</xref>,<xref rid="R23" ref-type="bibr">23</xref></sup> Site visits to PQC-supported hospitals provide opportunities to review site procedures and data collection processes.<sup><xref rid="R24" ref-type="bibr">24</xref></sup></p><p id="P64">A common and successful way that PQCs support hospitals is through developing and disseminating resources such as checklists and toolkits. These tools are provided by PQCs to assist hospital teams in implementing evidence-informed practices.<sup><xref rid="R20" ref-type="bibr">20</xref></sup> Toolkits may involve protocols or step by step lists that allow hospitals to ensure their work is done in a complete and thorough manner.<sup><xref rid="R25" ref-type="bibr">25</xref></sup> A commonly used resource for PQCs are <italic toggle="yes">PSBs</italic>.<sup><xref rid="R26" ref-type="bibr">26</xref></sup></p></sec></boxed-text><boxed-text id="BX2" position="float"><label>Box 2</label><caption><title>Ways for providers to engage with their state perinatal quality collaborative</title></caption><p id="P65">1. Identify your statewide PQC: the NNPQC provides a map of every state PQC (<ext-link xlink:href="https://nnpqc.org/" ext-link-type="uri">PQC US map</ext-link>).<sup><xref rid="R18" ref-type="bibr">18</xref></sup></p><p id="P66">2. Learn about the quality improvement efforts in your state: visit your state PQC Web site and review the resources and data reports available.</p><p id="P67">3. Actively engage with your statewide PQC in one or more of several roles<sup><xref rid="R17" ref-type="bibr">17</xref></sup>:
<list list-type="bullet" id="L10"><list-item><p id="P68">PQC leadership</p></list-item><list-item><p id="P69">QI initiative leadership</p></list-item><list-item><p id="P70">Advisory workgroup member</p></list-item><list-item><p id="P71">Grand rounds speaker bureau</p></list-item><list-item><p id="P72">In-person meeting</p></list-item></list></p><p id="P73">4. Be a champion for quality improvement: Improvement in maternal and infant care and outcomes needs strong provider engagement in quality improvement leadership at the hospital level.<sup><xref rid="R17" ref-type="bibr">17</xref></sup></p><p id="P74">5. Educate others: As you learn and get involved in quality improvement efforts share what you learn with other providers in your network.</p><p id="P75">Map lines delineate study areas and do not necessarily depict accepted national boundaries</p></boxed-text><boxed-text id="BX3" position="float"><caption><title>KEY POINTS</title></caption><list list-type="bullet" id="L12"><list-item><p id="P76">Quality improvement is an important, proven strategy to improve maternal and infant care and outcomes.</p></list-item><list-item><p id="P77">Patient safety bundles are evidence-informed tools used to improve hospital processes and outcomes.</p></list-item><list-item><p id="P78">Perinatal Quality Collaboratives comprehensively support quality improvement activities (eg, implementing patient safety bundles) in a variety of settings, leading to improved care and outcomes.</p></list-item></list></boxed-text><boxed-text id="BX4" position="float"><caption><title>CLINICS CARE POINTS</title></caption><list list-type="bullet" id="L14"><list-item><p id="P79">Quality improvement is an important, proven strategy to improve maternal and infant care and outcomes.</p></list-item><list-item><p id="P80">PSBs are evidence-informed tools to improve hospital processes and outcomes.</p></list-item><list-item><p id="P81">PQCs comprehensively support quality improvement activities (eg, implementing PSBs) in a variety of settings to improve care and outcomes.</p></list-item><list-item><p id="P82">There are many examples of PQCs using PSBs to successfully improve care processes and outcomes.</p></list-item><list-item><p id="P83">Multidisciplinary hospital teams are key for the success of PQCs and their quality improvement initiatives.</p></list-item></list></boxed-text></floats-group></article>