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      Tuberculosis (TB) is a challenging disease to diagnose, treat, and control globally and in the United States. TB is spread through the air from one person to another. TB bacteria are released into the air when a person with TB disease of the lungs or throat coughs, sneezes, speaks, or sings. People nearby may breathe in these bacteria and become infected.

      Globally, TB is one of the most common infectious diseases and the leading cause of death among people living with HIV (PLHIV). In 2010, a total of 8.8 million people become sick with TB disease, most of whom (82%) live in one of the 22 high burden countries for TB. While significant progress has been made toward the elimination of TB in the United States, this disease remains an urgent public health problem in many other parts of the world.

      TB in the United States reflects the global reality. Latest surveillance data show the annual TB incidence rate among the U.S.-born was 1.6 per 100,000 compared to 18.1 in foreign-born individuals. In 2010, 60% of all TB cases and 88% of drug-resistant TB cases1 in the United States occurred among people born in other countries. More than 75% of these individuals were born in just 15 countries. Many of CDC’s global TB control activities are focused in these high-burden and origin countries. Investing in TB control in high-burden settings reduces TB cases in the United States, costs less than screening at U.S. entry points, and saves funds that would be spent treating TB disease in the U.S.

      CS229517-A

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