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Candida spp. with Acquired Echinocandin Resistance, France, 2004–20101
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  1. Epidemiology of echinocandin resistance in Candida
    Personal Author:
    Grossman, Nina T.; Chiller, Tom M.; Lockhart, Shawn R.;
    Published Date:
    Sep 21 2014
    Source:
    Curr Fungal Infect Rep. 8(4):243-248.
    Description:
    Echinocandins are the newest antifungal agents approved for use in treating | infections in the US. They act by interfering with 1,3-β-D-glucan synthase and therefore disrupt cell wall production and lead to | cell death. There is no intrinsic resis...
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  2. Epidemiology and Risk Factors for Echinocandin Nonsusceptible Candida glabrata Bloodstream Infections: Data From a Large Multisite Population-Based Candidemia Surveillance Program, 2008–2014
    Personal Author:
    Vallabhaneni, Snigdha; Cleveland, Angela A.; Farley, Monica M.; Harrison, Lee H.; Schaffner, William; Beldavs, Zintar G.; Derado, Gordana; Pham, Cau D.; Lockhart, Shawn R.; Smith, Rachel M.;
    Published Date:
    Dec 14 2015
    Source:
    Open Forum Infect Dis. 2015; 2(4).
    Description:
    Background.  Echinocandins are first-line treatment for Candida glabrata candidemia. Echinocandin resistance is concerning due to limited remaining treatment options. We used data from a multisite, population-based surveillance program to describe ...
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  3. Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA
    Personal Author:
    Jung, Dong Sik; Farmakiotis, Dimitrios; Jiang, Ying; Tarrand, Jeffrey J.; Kontoyiannis, Dimitrios P.;
    Published Date:
    Nov 2015
    Source:
    Emerg Infect Dis. 21(11):1942-1950
    Description:
    Many uncommon Candida species that cause bloodstream infections (BSIs) are not well-characterized. We investigated the epidemiology, antifungal use, susceptibility patterns, and factors associated with all-cause death among cancer patients in whom un...
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  4. Candida lusitaniae MICs to the echinocandins are elevated but FKS-mediated resistance is rare
    Personal Author:
    Lockhart, Shawn R.; Pham, Cau D.; Kuykendall, Randall J.; Bolden, Carol B.; Cleveland, Angela A.;
    Published Date:
    Aug 28 2015
    Source:
    Diagn Microbiol Infect Dis. 84(1):52-54.
    Description:
    MIC values were generated for caspofungin, micafungin, and anidulafungin against 106 isolates of C. lusitaniae, and these values were compared to established epidemiologic cutoff values. The majority of isolates were wild type both by MIC value as we...
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  5. Declining Incidence of Candidemia and the Shifting Epidemiology of Candida Resistance in Two US Metropolitan Areas, 2008–2013: Results from Population-Based Surveillance
    Personal Author:
    Cleveland, Angela Ahlquist; Harrison, Lee H.; Farley, Monica M.; Hollick, Rosemary; Stein, Betsy; Chiller, Tom M.; Lockhart, Shawn R.; Park, Benjamin J.;
    Published Date:
    Mar 30 2015
    Source:
    PLoS One. 10(3).
    Description:
    BackgroundRecent reports have demonstrated a decline in bacterial bloodstream infections (BSIs) following adherence to central line insertion practices; however, declines have been less evident for BSIs due to Candida species.MethodsWe conducted acti...
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    Filetype[PDF - 539.32 KB]