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Candida spp. with Acquired Echinocandin Resistance, France, 2004–20101
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    Echinocandins are the newest antifungal agents approved for use in treating | infections in the US. They act by interfering with 1,3-β-D-glucan synthase and therefore disrupt cell wall production and lead to | cell death. There is no intrinsic resis...
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  2. Epidemiology and Risk Factors for Echinocandin Nonsusceptible Candida glabrata Bloodstream Infections: Data From a Large Multisite Population-Based Candidemia Surveillance Program, 2008–2014
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    Vallabhaneni, Snigdha; Cleveland, Angela A.; Farley, Monica M.; Harrison, Lee H.; Schaffner, William; Beldavs, Zintar G.; Derado, Gordana; Pham, Cau D.; Lockhart, Shawn R.; Smith, Rachel M.;
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    Background.  Echinocandins are first-line treatment for Candida glabrata candidemia. Echinocandin resistance is concerning due to limited remaining treatment options. We used data from a multisite, population-based surveillance program to describe ...
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  3. Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA
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    Emerg Infect Dis. 21(11):1942-1950
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    Many uncommon Candida species that cause bloodstream infections (BSIs) are not well-characterized. We investigated the epidemiology, antifungal use, susceptibility patterns, and factors associated with all-cause death among cancer patients in whom un...
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  4. Candida lusitaniae MICs to the echinocandins are elevated but FKS-mediated resistance is rare
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    Lockhart, Shawn R.; Pham, Cau D.; Kuykendall, Randall J.; Bolden, Carol B.; Cleveland, Angela A.;
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    MIC values were generated for caspofungin, micafungin, and anidulafungin against 106 isolates of C. lusitaniae, and these values were compared to established epidemiologic cutoff values. The majority of isolates were wild type both by MIC value as we...
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  5. Declining Incidence of Candidemia and the Shifting Epidemiology of Candida Resistance in Two US Metropolitan Areas, 2008–2013: Results from Population-Based Surveillance
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    Cleveland, Angela Ahlquist; Harrison, Lee H.; Farley, Monica M.; Hollick, Rosemary; Stein, Betsy; Chiller, Tom M.; Lockhart, Shawn R.; Park, Benjamin J.;
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    PLoS One. 10(3).
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    Background : Recent reports have demonstrated a decline in bacterial bloodstream infections (BSIs) following adherence to central line insertion practices; however, declines have been less evident for BSIs due to Candida species. : Methods : We condu...
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