104-Week Carcinogenicity Study in Male Rats 4,4′-Methylenebis (2-Chloroaniline) (MOCA)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  The purpose of this study was to evaluate and characterize the tumorigenic potential of the long-term ingestion of 4,4'-methylene-bis- (2-chloroaniline) in albino rats. The dietary administration of the test material was initiated on October 17, 1974 and was terminated eighteen months later on April 15, 1976. The animals were then fed the appropriate protein adequate or deficient basal diet and observed for an additional six months; and the study was terminated on October 14, 1976. [Description provided by NIOSH]
• Subjects:
  Carcinogens Hydrocarbons, Chlorinated Laboratories Neoplasms Occupational Health Pathology Safety Urine
• Keywords:
  Chlorine-organic-compounds; Rats; Laboratory-animals; Residues; Dosage; Pathology; Carcinogenesis; Urinalysis; Cancer
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 1 ; OSHA Region 5 ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-180
• NIOSHTIC Number:
  nn:20000733
• NTIS Accession Number:
  PB83-239475
• Citation:
  NIOSH 1977 Jul; :1-180
• CAS Registry Number:
  ar,ar′-Methylenebis[2-chlorobenzenamine (CAS RN 27342-75-2)
• Federal Fiscal Year:
  1977
• Performing Organization:
  Hazleton Labs. America, Inc., Vienna, VA
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:90af5ba76c18ac199a8a3e088331eb618be2bf6b80b8d87bc56666ac7fc428ab47dc1d81bcbcae68319015ea33adebe98ee8254ae4752fde62325bcdc8848a51
• Download URL:
  https://stacks.cdc.gov/view/cdc/234017/cdc_234017_DS1.pdf
• File Type:
  [PDF - 5.19 MB ]