Characteristics of Patients with Mild to Moderate Primary Pulmonary Coccidioidomycosis

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Blair, Janis E. ; Chang, Yu-Hui H. ; Cheng, Meng-Ru ; Vaszar, Laszlo T. ; Vikram, Holenarasipur R. ; Orenstein, Robert ; Kusne, Shimon ; Ho, Stanford ; Seville, Maria T. ; Parish, James M.
• Description:
  In Arizona, USA, primary pulmonary coccidioidomycosis accounts for 15%-29% of community-acquired pneumonia. To determine the evolution of symptoms and changes in laboratory values for patients with mild to moderate coccidioidomycosis during 2010-2012, we conducted a prospective 24-week study of patients with primary pulmonary coccidioidomycosis. Of the 36 patients, 16 (44%) were men and 33 (92%) were White. Median age was 53 years, and 20 (56%) had received antifungal treatment at baseline. Symptom scores were higher for patients who received treatment than for those who did not. Median times from symptom onset to 50% reduction and to complete resolution for patients in treatment and nontreatment groups were 9.9 and 9.1 weeks, and 18.7 and 17.8 weeks, respectively. Median times to full return to work were 8.4 and 5.7 weeks, respectively. One patient who received treatment experienced disseminated infection. For otherwise healthy adults with acute coccidioidomycosis, convalescence was prolonged, regardless of whether they received antifungal treatment.
• Subjects:
  Adult Aged Antifungal Agents Coccidioides Coccidioidomycosis Community-Acquired Infections Convalescence Female Humans Lung Diseases, Fungal Male Middle Aged Pneumonia Prospective Studies Severity Of Illness Index

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• Source:
  Emerg Infect Dis. 20(6):983-990.
• Document Type:
  Journal Article
• Place as Subject:
  Arizona
• Volume:
  20
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e622ce41585c0c718ca57451cb467e3e008b9c70f72000de541139d78b56720e
• Download URL:
  https://stacks.cdc.gov/view/cdc/23352/cdc_23352_DS1.pdf
• File Type:
  [PDF - 474.35 KB ]