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Mirna Expression Profiles Identify Drivers in Colorectal and Pancreatic Cancers

Published Date:

Mar 30 2012

Publisher's site:

http://dx.doi.org/10.1371/journal.pone.0033663 New Site Icon

Source:

PLoS One. 2012; 7(3).

[PDF-694.76 KB]

Details:

Personal Authors:

Piepoli, Ada ; Tavano, Francesca ; Copetti, Massimiliano ; Mazza, Tommaso ; Palumbo, Orazio ; ... More ▼

Keywords:

[+]

Pubmed ID:

22479426

Pubmed Central ID:

PMC3316496

Description:

Background and Aim

Altered expression of microRNAs (miRNAs) hallmarks many cancer types. The study of the associations of miRNA expression profile and cancer phenotype could help identify the links between deregulation of miRNA expression and oncogenic pathways.

Methods

Expression profiling of 866 human miRNAs in 19 colorectal and 17 pancreatic cancers and in matched adjacent normal tissues was investigated. Classical paired t-test and random forest analyses were applied to identify miRNAs associated with tissue-specific tumors. Network analysis based on a computational approach to mine associations between cancer types and miRNAs was performed.

Results

The merge between the two statistical methods used to intersect the miRNAs differentially expressed in colon and pancreatic cancers allowed the identification of cancer-specific miRNA alterations. By miRNA-network analysis, tissue-specific patterns of miRNA deregulation were traced: the driving miRNAs were miR-195, miR-1280, miR-140-3p and miR-1246 in colorectal tumors, and miR-103, miR-23a and miR-15b in pancreatic cancers.

Conclusion

MiRNA expression profiles may identify cancer-specific signatures and potentially useful biomarkers for the diagnosis of tissue specific cancers. miRNA-network analysis help identify altered miRNA regulatory networks that could play a role in tumor pathogenesis.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

RC0903CH47/CH/OID CDC HHS/United States
RC0903GA51/RC/CCR NIH HHS/United States
RC1003BS14/BS/FDA HHS/United States
RC1003CH50/CH/OID CDC HHS/United States
RC1003GA52/RC/CCR NIH HHS/United States
RC1103CH46/CH/OID CDC HHS/United States
RC1103GA47/RC/CCR NIH HHS/United States

Main Document Checksum:

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