PLoS OnePLoS ONEplosplosonePLoS ONE1932-6203Public Library of ScienceSan Francisco, USA232514403521022PONE-D-12-2126510.1371/journal.pone.0051147Research ArticleBiologyPopulation BiologyEpidemiologyInfectious Disease EpidemiologyMedicineEpidemiologyClinical EpidemiologyInfectious Disease EpidemiologyInfectious DiseasesBacterial DiseasesBacterial PneumoniaInfectious Disease ControlNon-Clinical MedicineHealth Care PolicyTreatment GuidelinesPublic HealthPulmonologyRespiratory InfectionsUpper Respiratory Tract InfectionsA Sustainable Strategy to Prevent Misuse of Antibiotics for Acute Respiratory InfectionsePrescription-Based Antibiotic StewardshipRattingerGail B.123MullinsC. Daniel2ZuckermanIlene H.26OnukwughaEberechukwu2WalkerLoreen D.2GundlapalliAdi45SamoreMatthew45DeLisleSylvain16*Veterans Affairs Maryland Health Care System, Baltimore, Maryland, United States of AmericaSchool of Pharmacy, University of Maryland, Baltimore, Maryland, United States of AmericaSchool of Pharmacy, Fairleigh Dickinson University, Florham Park, New Jersey, United States of AmericaVeterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah, United States of AmericaSchool of Medicine, University of Utah, Salt Lake City, Utah, United States of AmericaSchool of Medicine, University of Maryland, Maryland, United States of AmericaManzoliLambertoEditorUniversity of Chieti, Italy* E-mail: sdelisle@umaryland.edu

Competing Interests: All authors have completed the Unified Competing Interest form at www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare financial support from the Department of Veterans Affairs (SD), the Centers for Disease Control and Prevention (SD and MS), Elan Pharmaceuticals (GBR), the American Foundation for Pharmaceutical Education (GBR) and by the National Institutes of Health (GBR). There were no financial relationships with any organizations that might have an interest in the submitted work in the previous 5 years, and no other relationships or activities that could appear to have influenced the submitted work. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Conceived and designed the experiments: GBR CDM EO MS SD. Performed the experiments: GBR AG SD. Analyzed the data: GRB IHZ LDW SD. Wrote the paper: GBR CDM IHZ EO AG MS SD. Obtaining funding: MS SD Administrative, technical, or material support: GBR CDM AG LDW MS SD Study supervision: GBR AG SD.

201212122012712e51147197201221120122012This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.Backgrounds

Over 50% of antibiotics prescriptions are for outpatients with acute respiratory infections (ARI). Many of them are not needed and thus contribute both avoidable adverse events and pressures toward the development of bacterial resistance. Could a clinical decision support system (CDSS), interposed at the time of electronic prescription, adjust antibiotics utilization toward consensus treatment guidelines for ARI?

Methods

This is a retrospective comparison of pre- (2002) and post-intervention (2003–2006) periods at two comprehensive health care systems (intervention and control). The intervention was a CDSS that targeted fluoroquinolone and azithromycin; other antibiotics remained unrestricted. 7000 outpatients visits flagged by an ARI case-finding algorithm were reviewed for congruence with the guidelines (antibiotic prescribed-when-warranted or not-prescribed-when-unwarranted).

Results

3831 patients satisfied the case definitions for one or more ARI: pneumonia (537), bronchitis (2931), sinusitis (717) and non-specific ARI (145). All patients with pneumonia received antibiotics. The relative risk (RR) of congruent prescribing was 2.57 (95% CI = (1.865 to 3.540) in favor of the intervention site for the antibiotics targeted by the CDSS; congruence did not change for other antibiotics (adjusted RR = 1.18 (95% CI = (0.691 to 2.011)). The proportion of unwarranted prescriptions of the targeted antibiotics decreased from 22% to 3%, pre vs. post-intervention (p<0.0001).

Conclusions

A CDSS interposed at the time of e-prescription nearly extinguished unwarranted use targeted antibiotics for ARI for four years. This intervention highlights a path toward sustainable antibiotics stewardship for outpatients with ARI.

This material is the result of work supported with resources and the use of facilities at the VA Maryland Health Care System and the Salt Lake City VA Health System. This work was also supported in part by grants SHP-08-162 and IIR 06-119-1 from the Office of Research and Development, Health Services Research and Development Service, Department of Veterans Affairs. Development and validation of the ARI case-detection algorithm was supported by grants R01 CI000098, RFA HK000013 and 1 P01HK000069-01 from the Centers for Disease Control and Prevention. GR was supported by a postdoctoral fellowship grant from Elan Pharmaceuticals (2007–2009), an American Foundation for Pharmaceutical Education Faculty Fellowship (2009) and by a National Institutes of Health K12HD043489 training grant (2010–2011). The funding agencies and the commercial sponsor played no role in the study design; in the collection, analysis, and interpretation of the data; in the writing of the report; and in the decision to submit the paper for publication.
Introduction

Microorganisms resistant to antibiotics increase the mortality, morbidity and costs of infections. Without a drug development infrastructure that can keep pace with the rapidly evolving resistance mechanisms, these organisms are expected to threaten public health for years to come.

Because exposure to antibiotics is a key promoter of bacterial resistance [1], efforts aimed at minimizing the unnecessary use of antibiotics could slow the rate at which resistance emerges. To date, such efforts have largely targeted uncomplicated acute respiratory infections (ARI) [2], a rubric that includes outpatient conditions for which antibiotics are routinely over-prescribed, namely acute bronchitis, acute sinusitis, acute pharyngitis and nonspecific upper respiratory tract infection (URI) [3]. Traditional educational methods aimed at health care providers can reduce unwarranted antibiotics use, but their effect tend to be modest [2] and ephemeral [4].

In this work, we re-engineered pharmacy processes to interpose a clinical decision support systems (CDSS) at the time of order entry for selected antibiotics [5]. The hypothesis was that integrating electronic tools within the natural flow of care could sustainably counteract a persistent form of unwarranted drug use.

Methods

This is a retrospective, observational study designed to assess the effect of a CDSS on congruence of antibiotics prescribing with widely endorsed ARI treatment guidelines [6]. The study period ranged from January 2002 to December 2006. The CDSS intervention started in January 2003 at the Veterans Affairs (VA) Maryland Health Care System and continued through the end of the study period. The VA Salt Lake City Health Care System served as a control site. The CDSS targeted azithromycin and gatifloxacin, which had been the most frequently prescribed antibiotics in outpatients with uncomplicated ARI at the intervention site. All other outpatient antibiotics remained unrestricted.

Ethics Statement

The Institutional Review Boards of the participating VA health systems, the University of Maryland and the University of Utah, approved the study. The study was granted a waiver of consent as risks were limited to information confidentiality and it involved a large number of participants.

Description of the InterventionSetting and process engineering

The CDSS intervention was part of a larger quality improvement initiative that targeted 26 medications and was used by at least 1379 unique providers during the study period. The CDSS: 1) deployed drug-specific guideline recommendations as clickable choices during order entry; 2) mined the electronic medical record (EMR) for patient/context specific information; and 3) based on what the provider had clicked on, issued a note documenting the rationale for drug use. The providers could then accept or modify this note before committing it to the EMR. The presence of this note was verified by pharmacy, but its content was not routinely audited.

Antibiotics CDSS

The azithromycin and gatifloxacin CDSS included treatment paths for the following diseases: community-acquired pneumonia, acute bronchitis, acute sinusitis, non-specific upper respiratory infection (URI) and exacerbations of chronic obstructive pulmonary disease (COPD). An “Other” path provided access to either drug for provider-supplied indications.

For the community-acquired pneumonia path, providers clicked on the diagnostic elements that raised their index of suspicion for pneumonia and were then led to a prescription. For the acute bronchitis [7], acute sinusitis [8] and non-specific URI [9] paths, the software first verified that the clinical condition matched the guideline’s case definition and then sought to identify clinical circumstances where antibiotics could be warranted. This included acute bronchitis patients with abnormal vital signs (temperature >38°C or respiratory rate >22 breath per minute or pulse >100) or with clinical signs of lung consolidation, and acute sinusitis patients who were febrile (temperature >38°C) or who had severe or persistent (7 days or more) symptoms. Under those circumstances, the CDSS led to an antibiotic prescription. For cases with acute bronchitis and sinusitis where guidelines suggested that antibiotics could be safely withheld, and for all cases with non-specific URI, the software did not lead to a prescription. Instead, providers were advised on how to maintain patient satisfaction when withholding antibiotics. Providers reaching such an outcome but wishing to prescribe antibiotics anyway could override the system by using a path known to lead to a prescription (e.g. the “Other” path or the “Pneumonia” path) and then typing their own rationale for drug use in the CDSS-issued note. They were also free to prescribe antibiotics not targeted by the CDSS.

Participants

A case-detection algorithm previously found to identify 76% of patients with an influenza-like illness [10] was applied to EMR-derived relational databases. Outpatient visits during the study period (n = 4.1 million) were flagged if providers either assigned an ARI-related diagnostic code [10] or prescribed a cough suppressant, and if the clinical note documented at least two ARI symptoms, as assessed by automated text analysis of [10].

Record Review

With the exception of notes generated by the CDSS itself, all free-text EMR entries on the day of flagged visits were manually abstracted for data elements needed to assign ARI diagnoses and treatment. Reviewers cross-validated 10% of each other’s work; conflicts were resolved through arbitration with a pulmonary medicine specialist. Inter-rater reliability was determined using 15% of the total sample for the “cough”, “sputum production”, “cough duration” and “sputum production duration” symptoms (kappa statistics = 0.80, 0.87, 0.87 and 0.87 respectively at the intervention site and 0.86, 0.79, 0.91, and 0.92 respectively at the control site). Structured EMR data elements, such as prescriptions and vital signs, were extracted from the EMR [10] and later appended to the review database.

Exclusion, Diagnostic and Treatment Criteria

We reviewed all of the records flagged by the case-detection algorithm at the intervention site. Based on preliminary results and published effect sizes [2], we calculated that abstracting 2,000 flagged outpatient encounters would have 80% power to detect a 10% change in congruence at the control site.

Of the 7000 visits manually reviewed, 3169 were excluded according to pre-defined criteria: 1) not an outpatient (n = 141); 2) not an ARI (n = 855); 3) not an in-person, initial visit for a given ARI episode (no prior ARI visit within 3 weeks) (n = 1093); 4) prior ARI episode(s) during the study period i.e. patients were used only once (n = 140); 5) stated diagnosis of COPD, whether or not the visit was related to an exacerbation of this disease (n = 501); 6) acute pharyngitis as the only ARI diagnosis (n = 431).

A visit was labeled pneumonia if a provider note listed this diagnosis as likely. Other ARI case definitions and conditions justifying antibiotics matched that of the guidelines (Table 1) [7], [8], [9], [11]. Visits for conditions other than pneumonia or non-specific URI could be labeled with more than one ARI diagnoses. Antibiotics were categorized as “warranted” if they were justified for at least one ARI diagnosis. We defined an ARI visit as “congruent” with the guidelines if an antibiotic was either prescribed or withheld in accordance with the criteria outlined in Table 1.

10.1371/journal.pone.0051147.t001Diagnostic and treatment criteria for ARI.
ARI ConditionDiagnostic CriteriaAntibiotic Treatment Criteria
PneumoniaClinician’s documented diagnostic impressionAntibiotics always warranted
Acute Bronchitis1) Acute cough (productive or not) 2) Cough duration <21 daysAntibiotics not warranted
Pharyngitis1) Sore throat 2) Erythematous throatAt least three of the following four symptoms/signs: 1) History of fever or temperature >100.4°F (38°C); 2) Tonsillar exudate; 3) Tender anterior cervical lymphadenopathy; 4) Absence of cough
Sinusitis1) Purulent nasal discharge2) Facial or sinus pain 3) Sinus tenderness4) Productive coughSevere symptoms or symptom duration ≥7 days including purulent nasal discharge/drainage AND (Maxillary facial or tooth (sinus) pain OR tenderness)
Non-Specific Acute Upper Respiratory Infection1) Absence of a predominant sinus, pharyngeal or lower airway symptom 2) Nasal discharge 3) Sputum production from the throatAntibiotics not warranted
Statistical Analysis

Descriptive statistics and results from bivariate tests for association were generated for the study sample and informed the multivariable analyses. Multivariable logistic regression and difference-in-difference regression analyses using a Poisson distribution with a log link and modified Poisson approach to obtain robust standard error estimates [12] were developed to estimate the impact of the CDSS intervention on overall antibiotics prescribing congruence (SAS software v. 9.2, SAS Institute Inc. Cary, NC). The size of inference tests for covariates in all adjusted regression models was set a priori at 0.05. Patient-specific covariates were age, marital status at index visit date, sex and self-reported race/ethnicity (African-American/other).

ResultsCharacteristics of Study Patients and ARI Diagnoses

The study included 3831 unique patients with an initial visit for ARI. Patients were mostly older males (Table 2). The most common ARI diagnosis was acute bronchitis (76.5% of all ARI visits), followed by pharyngitis (40.7%), sinusitis (18.7%), pneumonia (14.0%) and non-specific URI (3.8%). More than one ARI diagnosis was found in 56.9% of ARI visits (Table 2).

10.1371/journal.pone.0051147.t002Demographics and Diagnoses.
CharacteristicsIntervention Site N (%)Control SiteN (%)
Sample Size26691162
Sex
Male2439 (91.4)1096 (94.32)
Female230 (8.6)66 (5.68)
Self-Reported Race
African American1775 (66.5)18 (1.55)
White601 (22.5)697 (59.98)
Latino17 (0.6)41 (3.53)
Other10 (0.4)14 (1.20)
Missing266 (10.0)392 (33.73)
Marital Status
Married792 (29.7)620 (53.36)
Unmarried1877 (70.3)542 (46.64)
Age at Encounter Date, years
Mean55.6 (13.9)59.1 (15.55)
Median5358
Range16–9719–91
ARI Visits, by year
 Pre - intervention
 2002373 (14.0)344 (29.60)
Post - intervention
2003673 (25.2)253 (21.77)
2004481 (18.0)185 (15.92)
2005770 (28.9)225 (19.36)
2006372 (13.9)155 (13.34)
ARI Visits, by Condition(s)
Pneumonia337 (12.6)200 (17.2)
Bronchitis Only941 (35.3)292 (25.1)
Sinusitis Only57 (2.1)66 (5.7)
Bronchitis plus pharyngitis918 (34.4)281 (24.2)
Bronchitis plus sinusitis124 (4.6)109 (9.4)
Bronchitis plus pharyngitis plus sinusitis139 (5.2)127 (10.9)
inusitis plus pharyngitis51 (1.9)44 (3.8)
on-specific URI102 (3.8)43 (3.7)
Effect of the CDSS on Warranted Use of Antibiotics

Of the 624 visits where antibiotics were warranted (Table 3), most were for pneumonia (n = 537, 86%). All pneumonia patients received antibiotics. Of the remaining 87 visits, 18 (20.7%) did not receive antibiotics.

10.1371/journal.pone.0051147.t003Antibiotic Prescriptions by Visits.
Intervention SiteControl Site
AntibioticsWarrantedUnwarrantedWarrantedUnwarranted
20022003–620022003–620022003–620022003–6
Prescribed (Targeted)2622555454811134100
Prescribed (Others)1311084583235051148
Not Prescribed07195132665182404
Total (3831)39342334195477166267652

Figure 1 compares pre- vs. post-intervention proportions of ARI visits prescribed an antibiotic. The upper panel focuses exclusively on ARI visits where antibiotics were warranted and illustrates that providers prescribed antibiotics in a high proportion of such visits. These proportions did not change appreciably from the pre- to the post-intervention periods at both study sites. The targeted antibiotics remained the most prescribed of the warranted antibiotics at both study sites (66.7% vs. 67.2% (Maryland) and 67.6% vs. 68.9% (Utah) of total warranted prescriptions, pre- vs. post-intervention).

10.1371/journal.pone.0051147.g001Effect of the CDSS on antibiotics use for ARI.

Comparison of antibiotic utilization for ARI between the time periods before (dark bars) or after (light bars) introduction of the CDSS. Y-axis represents proportions of ARI visit where antibiotics were prescribed. For comparisons involving antibiotics targeted by the CDSS (dark and light bar pairs over the word “Targeted”), proportions are given by VTargeted/(VTargeted+VNoAntibiotic), where VTargeted is the number of visits where targeted antibiotics were prescribed and VNoAntibiotic the number of visits not issued antibiotics. For comparisons involving other antibiotics (dark and light bar pairs over the word “Other”), proportions are given by VOther/(VOther+VNoAntibiotic), where VOther is the number of visits where Other antibiotics were prescribed. Upper panel only includes ARI visits where antibiotics were indicated; lower panel only includes those ARI visits where antibiotics were not indicated. Results for the intervention and the control sites are given on the left and right side of the figure, respectively. Note that proportions of visits where antibiotics were prescribed did not change pre vs. post-intervention, except for a decrease in Targeted antibiotics use at the intervention site.

Effect of the CDSS on Unwarranted Use of Antibiotics

The majority of ARI visits did not include documentation supporting the use of antibiotics (n = 3207 or 83.7% of total ARI visits, Table 3). For the drugs targeted by the CDSS, the proportion of unwarranted prescriptions decreased from 22% to 3.3% (p<0.0001) of visits, pre- to post-CDSS (Fig. 1, lower panel). The equivalent proportion remained unchanged for the Other antibiotics at the intervention site (30.1% to 30.5%), or for both the Targeted (16% vs. 20%) and the Other (22% vs. 27%) antibiotics at the control site.

Effect of CDSS on Overall Antibiotic Prescribing Congruence with the ARI Guidelines

The proportion of total ARI visits where antibiotics use was congruent with the guidelines increased from the pre- to the post-intervention periods at the intervention site (from 0.63 to 0.72, p = 0.0001), but was unchanged at the control site (from 0.74 to 0.69, p = 0.10). At the intervention site, congruence increased in the first post-intervention year (0.72 (95% CI = (0.68, 0.75) in 2003) and remained stable afterwards (0.73 (95% CI = (0.69, 0.77) in 2004, 0.72 (95% CI = (0.69, 0.75) in 2005, and 0.73 (95% CI = (0.69, 0.78) in 2006). Prevalence ratios of antibiotics prescribing congruence were obtained by site and by year through adjusted multivariable logistic regression models. Adjusted multivariable difference-in-difference models between the two study sites, post- vs. pre-intervention periods, revealed a relative risk (RR) of a congruent prescription to be 1.24 (95% CI = (1.110, 1.391)), in favor of the intervention site. The impact of the intervention was found to be greatest for the targeted antibiotics (RR = 2.57; 95% CI = (1.865, 3.540)). Prescribing congruence for antibiotics not targeted by the intervention was unchanged (adjusted RR = 1.18; 95% CI = (0.691, 2.011)). No change was detected in congruence when no antibiotics were prescribed (adjusted RR = 0.99; 95% CI = (0.990, 1.00)). Favorable adjusted relative risks persisted for the sub-group of patients without pneumonia (n = 3294, RR = 1.27, 95% CI = (1.112, 1.457)) and in patients with acute bronchitis as their only ARI diagnosis (n = 1233, RR = 1.32; 95% CI = (1.042, 1.678)).

Discussion

In this work, a CDSS interposed treatment guidelines at the time of electronic order entry for antibiotics frequently used for outpatients with ARI. We report that the indicated use of the two antibiotics targeted by the CDSS, azithromycin and gatifloxacin, remained undiminished, but that their unnecessary use for ARI was curtailed for a 4-year period. This outcome was not observed for antibiotics not subject to the CDSS at the intervention and at the control sites.

The strengths of our study include the long duration of the intervention, the large sample size, and explicit case definitions and treatment criteria. Statistical comparisons could be made not only across the pre vs. post intervention time period, but also between the targeted and non-targeted antibiotics. Because pre- and post-intervention data was available from the intervention and the control site, we could also use a quasi-experimental difference-in differences approach to control for factors other than the CDSS that could be contributing to time-dependent changes in congruence to ARI antibiotics guidelines. In absolute terms, the overall 9.5% post-intervention decline in unwarranted antibiotic use for ARI was consistent with the 9.7% median reduction observed in 30 conventional intervention trials reviewed by Ranji et al. [2]. What was exceptional is that we could attribute this decline almost entirely to the only two antibiotics targeted by the CDSS. For these antibiotics, CDSS filtered utilization apparently as intended: azithromycin and gatifloxacin remained the most popular antibiotics when indicated for ARI, but were seldom used when not needed.

From a safety and tolerability standpoint, providers must be allowed to override the recommendations of a CDSS. This design requirement could have allowed providers to bypass the chief aim of the intervention, which was to convince them not to prescribe antibiotics unnecessarily for ARI. In a first scenario, they could have redirected ingrained misutilization to antibiotics not subject to the CDSS. Had this been the only effect of the intervention, we estimate that the proportion of ARI visits where antibiotics were not warranted but where agents other than azithromycin and gatifloxacin were prescribed should have risen above 50% in the post-intervention period. Because this proportion remained unchanged at 30%, our data argue that the CDSS did not merely shunt misutilization toward alternative, unrestricted drugs. In a second scenario, providers could have assigned the diagnosis of “pneumonia” more liberally, thereby seemingly justifying antibiotics that, in fact, were not indicated. Had providers used this tactic to justify all unwarranted prescription of the targeted agents, the proportion of all ARI visits where the targeted antibiotics were prescribed would have remained unchanged. In reality, this proportion decreased from 21.7% at baseline to 11.8% post-intervention. Providing further reassurance that outcomes were not due to systematic “gaming” of the process, subgroup analyses that either excluded patients with a pneumonia diagnosis or that included only patients whose sole diagnosis was acute bronchitis yielded findings comparable to those found in the full cohort. Overall, and even though unintended actions such as those outlined in the above scenarios could have occurred more than occasionally, our data suggest that the main effect of the CDSS was to extinguish unneeded prescriptions of the targeted agents.

Many factors could limit the generalizability of our results. The study did not employ a randomized allocation process, leaving it susceptible to well-described biases [13]. The intervention was implemented at only one site, in the favorable context of a comprehensive health care system whose providers were familiar with prescription-based CDSS. As the difference in initial guideline-congruent prescribing between our two study sites illustrates, antibiotic prescribing may vary widely between sites [14], [15], [16]. Thus, a process similar to the one described in this study may need adjustments, require significant provider education and yet yield different outcomes when implemented elsewhere. The retrospective data collection meant that symptoms and signs were assumed to be absent if they were not documented in the medical record. Thus, ARI episodes could have been missed or mislabeled, along with the rationale justifying the use of antibiotics. Although prior studies aimed at improving antibiotics utilization have returned similar results in VA and non-VA environments [17], our study population was mostly male and did not include pediatric age groups or patients with COPD. By focusing on initial visits for ARI, the study also did not address ARI patients returning to clinics with unabated or worsening ARI symptoms. Because multiple practitioners, from medical students to attending physicians, were often involved in assessing patients, we could not formally control for potential predictors of prescribing congruence such as individual practitioners’ prior practices, level of experience and exposure to the CDSS. These limitations represent design opportunities for future, hopefully prospective multisite studies aimed at determining how similar interventions based would fare when extended to more antibiotics or to other health care settings.

The rate at which antibiotics are inappropriately used for ARI remains high but has been decreasing for more than a decade [18], [19], [20]. This decline, however, exhibits unfavorable features in an aging population: it has been concentrated in the pediatric population and may not be occurring at all in patients 50 years or older [21]. The decline has also not affected all antibiotics equally, with ARI-related utilization of azithromycin and fluoroquinolones actually increasing [21]. Thus, there is a continued need to develop better methods to improve ARI-related antibiotics use. CDSS have long proven capable to change prescribing practices, with most published applications directed at improving drug dosing [22] and safety monitoring [23], [24]. CDSS have also shown the potential to improve utilization of antibiotics, particularly in the hospital environment [25], [26]. To date, however, examples of demonstrated utility in the outpatient arena remain scarce [27], [28]. In the only study that included adults with ARI [28], providers were given the opportunity to consult a stand-alone CDSS in order to receive patient-specific recommendations. Our intervention is distinctive in that our CDSS was neither stand-alone nor optional. Instead, the CDSS was incorporated into a comprehensive EMR and interposed in the normal workflow leading to an e-prescription. The CDSS also did more than issue recommendations: it either did or did not lead to order entry and recorded the prescribing rationale thereby imparting at least the possibility of future accountability to a process that was otherwise operating as an honor system. These features, which had been associated with CDSS effectiveness in other domains [29], [30], were meant for the intervention to be stronger than what had previously been attempted for antibiotics stewardship purposes [5]. Yet, the path illustrated here did not include the vigorous traditional approaches associated with larger effect sizes in past trials i.e. one-on-one interactions, concurrent order reviews or practice audits [2], [31]. Our results therefore raise the hope that, at least for outpatients with ARI, counteracting antibiotic abuse may not require time-consuming, ultimately unsustainable activities.

From a disease-management standpoint, this CDSS intervention stood at a disadvantage because it targeted only a minority of the agents that could be used to treat ARIs. The system could nevertheless have effected large changes in overall guideline-congruent prescribing for ARI if it had fostered the transmission of information from providers to providers. Two lines of reasoning suggest that extra-CDSS educational transmission was not a major outcome of this intervention: 1) congruence gains were attributable to improved utilization of the CDSS-targeted antibiotics only; and 2) those gains were realized in the first post-intervention year and did not further increase afterwards. Thus, prescribing congruence did not exhibit the gradual expansion that would have been expected from an increasing the proportion of providers familiar with the ARI guidelines. Whether or not these outcomes are particular to a teaching institution with rapid housestaff turnover, they serve as a reminder that much more work will be required before we know how to best design, target and integrate prescription-based interventions to optimize the overall management of ARI.

This material is the result of work supported with resources and the use of facilities at the VA Maryland Health Care System and the VA Salt Lake City VA Health Care System (including VA Salt Lake City IDEAS Center). The authors would like to thank Shawn Loftus and Robert Sawyer MD, Brett South, MS and Shuying Shen, MStat for technical help with the institutional databases, the VA Informatics and Computing Infrastructure (VINCI) team for data acquisition and processing; Philip VanCamp, Carol Rudo RPh, Christopher Gallagher RPh, Nimalie Stone MD and Trish M. Perl MD for their help with the CDSS content and with the design and implementation of the CDSS process.

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