Family history of a chronic disease, such as high blood pressure, is an important predictor of future disease. The integration of genomics information into public health activities offers the opportunity to help raise awareness among populations at high risk for high blood pressure.
The prevalence of high blood pressure in blacks at any age is about twice that of whites. Detroit is second among major U.S. cities in the percentage of residents who are black (81.6%). According to data from the Behavioral Risk Factor Surveillance System 1998–2002, the perceived health status of Detroit respondents was one of the worst in Michigan; 17.4% of Detroit respondents reported no health care coverage; 69.6% reported being obese or overweight; and 33.1% reported no physical activity.
The Michigan Department of Community Health and the University of Michigan's Center for Genomics and Public Health collaborated on a pilot program to develop a worksheet emphasizing the importance of personal family history of high blood pressure. The handout was distributed to individuals at primarily black, Detroit-area churches during an annual screening event for high blood pressure and stroke.
Approximately 500 handouts were distributed; a collaborative effort was achieved; genomics information was integrated into an existing program; the ability to reach churches in a predominantly black community was demonstrated; consumers reported interest in the subject matter; and an appropriate literacy level for the handout was attained.
The strengths of this pilot program and suggested modifications may serve to guide others in genomics and/or chronic disease programs in future endeavors.
"It is not a question of
High blood pressure is a common and serious public health problem that affects about 30% of the U.S. adult population (
a family history of high blood pressure
African American ancestry
age 65 years or older
low socioeconomic status
overweight or obesity
a sedentary lifestyle
excess intake of dietary sodium and/or insufficient intake of potassium
excess consumption of alcohol (
Although high blood pressure is serious, the majority of individuals diagnosed do not have their blood pressure controlled (
High blood pressure can be prevented by a complementary application of strategies that targets the general population and individuals at high risk. Current national guidelines recommend nonpharmacologic therapy, including lifestyle modifications, for primary prevention and treatment of high blood pressure (
The prevalence of high blood pressure varies among populations. The most systematic comparison of ethnic groups has been between black and white individuals with hypertension (
The Michigan Behavioral Risk Factor Surveillance System (BRFSS), combining 1997, 1999, and 2001 results, found that the proportion of blacks in Detroit who had ever been told by a health professional that they had high blood pressure was 34.9%, and the proportion of whites was 21.4% (
A family health history reflects the outcome of numerous influences, including genetics, ethnicity, culture, and environment. The family health history holds important clues to current and future health risks for almost all chronic diseases, including high blood pressure. According to Yoon et al, "Evidence suggests that family history is useful for predicting disease when there are multiple family members affected, relationship among relatives is close and disease has an earlier onset than expected" (
An annual national mail survey,
It has recently been stated that "certain subgroups of the population might benefit from targeted programs to raise awareness about the collection and recording of family health histories" (
Family history has been recognized as a significant risk factor for high blood pressure since the 1930s and confirmed in numerous subsequent observational studies (
In many families, high blood pressure is most likely a polygenic condition, meaning that multiple genes contribute to the development of high blood pressure. In other families, high blood pressure may be caused by a single gene that strongly influences blood pressure. Susceptibility genes have been localized, and candidate genes include those encoding angiotensinogen, angiotensin receptor-1, the beta-3 subunit of guanine nucleotide-binding protein, and tumor necrosis factor receptor-2 (
Family history is a tool that incorporates the genetic risk of an individual and can easily be used in public health practice. Thus, the MDCH and the UM–CGPH collaborated to develop a handout that emphasizes the importance of a personal family history of high blood pressure. The target audience was black adults in Detroit. The goal of the pilot project was to enable consumers to collect individual family history information and then to use this information to identify personal risks and possible health measures to prevent high blood pressure.
The city of Detroit is located in Wayne County, which is in southeast Michigan. It is the tenth largest city in the United States by population and is second among major U.S. cities in the percentage of blacks (81.6%) (Figure) (
Black population of Detroit, Mich. Reproduced with permission from Wayne State University, Center for Urban Studies.
According to 1998–2002 BRFSS data, the perceived health status of Detroit respondents was one of the worst in Michigan (
To test the feasibility of introducing the importance of family history and high blood pressure in a black population, we collaborated with an established project that offers stroke and blood pressure screening and education to faith-based groups in the Detroit area. The event,
Participating churches identify a contact person, typically a parish nurse or health coordinator. Each contact person receives a workbook, material to distribute during the program, blood pressure measurement equipment, and one-day training by MDCH Cardiovascular Program staff. In the past, there have been up to 90 churches participating, 1907 individuals screened, and 270 individuals trained during the month-long event. The population reached is more than 75% black. A key component of the program is the emphasis on standardized, accurate blood pressure screening.
Based on the demographics of Detroit,
Download the
MDCH and UM-CGPH collaborated to develop the content of the
The introductory page of the handout includes three questions on knowledge of, attitude toward, and preventive actions for a family history of high blood pressure. The handout includes a worksheet that encourages collection of the family history of high blood pressure, heart disease, and stroke, including age of onset and age and cause of death. The consumer is encouraged to start with first-degree relatives (parents and siblings) and then to extend to second-degree relatives (grandparents and aunts/uncles). This approach of adding affected relatives and age of onset provides a simple overview for risk assessment, which can be used by families and their health care providers. The worksheet also emphasizes the importance of sharing the collected information with medical providers and family and discussing screening and healthy lifestyles with offspring. The last page highlights that high blood pressure is a chronic condition requiring evaluation and treatment.
The proposal for this project was presented to the
Approximately 500 copies of the
Overall, this pilot had several strengths: handouts were distributed to a population at high risk for high blood pressure; a collaborative effort was achieved between an academic center and state health department chronic disease and genomics programs; genomics information was successfully integrated into an existing program; the ability to reach churches in a predominantly black community was demonstrated; the consumers reported interest in the subject matter; the difficult task of attaining an appropriate literacy level of the material was advanced; and a worksheet format for a family history tool was developed. The worksheet format is simple, inexpensive, and easily integrated into other chronic disease materials.
Limitations of this pilot include a lack of field testing for consumers' opinion about the readability of the handout. We would like to have evaluated the audience's understanding of the information and whether the proper messages were conveyed. Also, while the MDCH Cardiovascular Health and Genomics Programs received indirect feedback about the tool from the church nurses, the programs and the nurses did not systematically collect information from the consumers on the usefulness of the handout and the worksheet.
The MDCH Genomics Work Group and two additional CDC-funded state genomics programs reviewed this pilot project. Possible suggestions for the future include changing the handout in the following ways:
Modifying the format (e.g., using bullet points to reduce verbiage, separating the educational component from the family history tool for clarity and utility);
Revising current content (e.g., simplifying instructions for family history worksheet, further lowering the literacy level); and
Adding more information (e.g., additional chronic diseases, incorporating culturally appropriate messages and images).
The development and use of a general consumer awareness handout is an iterative process. Therefore, the next steps for the program include further enhancements of the handout, field testing of the handout and worksheet, and collaboration with other possible channels of dissemination such as physicians and local health departments.
This pilot of a general consumer awareness handout on family history and high blood pressure demonstrated the challenges of developing material on this complicated topic. One suggestion is to implement this kind of activity at a place where participants can read the material, complete a feedback form, and return for discussion. Possible settings for this scenario include waiting rooms at physicians' offices prior to routine physicals or waiting rooms at local health departments prior to health screenings and/or immunizations. This context would provide a direct and immediate communication with a medical provider to highlight the family history and prevention messages. Future plans include distributing this handout at a science museum in Detroit, targeting a younger audience in a nonreligious setting.
The circumstances of this pilot limited the ability to collect feedback information on behavior and attitude change. It was hoped that this type of feedback would be gained from the parish nurses. Because of time constraints, however, collection of feedback was not feasible. Future initiatives should include collection of follow-up information. For instance, a focus group with participants could strengthen the content of the handout and provide feedback on methods to collect follow-up information.
In summary, this pilot project was a worthwhile activity that will be adapted for use in other settings. Additionally, the collaborative process of developing and distributing the handout is an example of how to integrate genomics into existing resources within chronic disease programs in other state health departments.
This project was financially supported in part by a CDC cooperative agreement, project U58/CCU522826, from the Chronic Disease Prevention and Health Promotion Programs, Component 7, Genomics and Chronic Disease Prevention, Program Announcement 03022, and by a Center for Genomics and Public Health cooperative agreement, project S1957-21/23, from the Association of Schools of Public Health and the CDC.
We thank the American Heart Association, Greater Midwest Affiliate, Toni Price, and the parish nurses who participated in
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
Possible Risk Factors for High Blood Pressure in Detroit
| Family history of high blood pressure | Unknown |
| African American ancestry | Majority African American |
| Over 65 years | Not relevant |
| Lower socioeconomic status | One of lowest household incomes in large U.S. cities |
| Overweight or obese | High proportion of obese or overweight respondents |
| Sedentary lifestyle | Highest proportion of no physical activity in leisure time |
| Excess intake of dietary sodium and/or insufficient intake of potassium | Unknown |
| Excess alcohol consumption | Not relevant |
Source: National High Blood Pressure Education Program (
Sources:
Michigan BRFSS data do not appear to support this risk factor for the Detroit population.