Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Morris, J. Glenn
Description:
Cholera has affected humans for at least a millennium and persists as a major cause of illness and death worldwide, with recent epidemics in Zimbabwe (2008-2009) and Haiti (2010). Clinically, evidence exists of increasing severity of disease linked with emergence of atypical Vibrio cholerae organisms that have incorporated genetic material from classical biotype strains into an El Tor biotype background. A key element in transmission may be a recently recognized hyperinfectious phase, which persists for hours after passage in diarrheal feces. We propose a model of transmission in which environmental triggers (such as temperature) lead to increases in V. cholerae in environmental reservoirs, with spillover into human populations. However, once the microorganism is introduced into a human population, transmission occurs primary by "fast" transmission from person to person (taking advantage of the hyperinfectious state), without returning to the aquatic environment.
Subjects:
[+]
Cholera Environment Humans Models, Biological Pandemics
Source:
Emerg Infect Dis. 17(11):2099-2104.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:618aef4168efdaeac0f6c7f11d39cb8fa8b7ee13f5a90b0e7162e75ab3147e34
Download URL:
https://stacks.cdc.gov/view/cdc/18596/cdc_18596_DS1.pdf
File Type:

Supporting Files

• 	11-1109-F.gif	gif
  	11-1109-F.jpg	jpeg
  	11-1109-Techapp_1p.pdf	pdf
  	11-1109.nxml	txt
  	license.txt	txt

More +