Prostaglandin regulation of airway smooth muscle tone.

Details

• Personal Author:
  Bouhuys A ; Douglas JS ; Lewis AJ ; Orehek J
• Description:
  In-vitro experiments indicate that the tone of the isolated guinea- pig trachea is modulated by the prostaglandins released subsequent to injection of histamine (51456) and acetylcholine (51843), if the prostaglandins (11000263) reach the airway smooth muscle. To prevent prostaglandin interference when assessing the effects of contractile agents, the tracheal strips required treatment with prostaglandin synthesis inhibitors, including aspirin (50782) and indomethacin (53861). [Description provided by NIOSH]
• Subjects:
  Musculoskeletal System Occupational Health Respiratory System Safety
• Keywords:
  Analgesics Drugs Muscle-contractions Muscle-functions Muscle-relaxants Muscle-tone NIOSH-Grant NIOSH-Publication Pharmacology Respiratory-functions Respiratory-system

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• ISSN:
  0369-4887
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  84-85
• Volume:
  245
• Issue:
  142
• NIOSHTIC Number:
  nn:00036329
• Citation:
  Nature, New Biology 1973 Sep; 245(142):84-85
• Contact Point Address:
  John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
• CAS Registry Number:
  Acetylcholine (CAS RN 51-84-3) ; Aspirin (CAS RN 50-78-2) ; Histamine (CAS RN 51-45-6) ; Indomethacin (CAS RN 53-86-1) ; Prostaglandins (CAS RN 11000-26-3)
• Federal Fiscal Year:
  1973
• Performing Organization:
  John B. Pierce Foundation of Connecticut Inc, New Haven, Connecticut,
• Peer Reviewed:
  True
• Start Date:
  19700901
• Source Full Name:
  Nature, New Biology
• End Date:
  19770630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0131ca94238162fffb0011414199be510f8ccfa124dd6a65fc55016309d8e9e541efce0ed2fd482ee96600be67e15b20b9127165b4746a34e7caee9cd49671c6
• Download URL:
  https://stacks.cdc.gov/view/cdc/183957/cdc_183957_DS1.pdf
• File Type:
  [PDF - 1.94 MB ]