Biochemical mechanisms of cadmium-induced anemia.

Details

• Personal Author:
  Urbanowicz H
• Description:
  Like so many other nonferrous metals, the production and use of cadmium has shown tremendous expansion in the last two decennials. New important fields of its utilization have been created by the development and increased use of nuclear energy devices, modern electronic equipment and last but not least--space research. Cadmium is well known to be toxic to humans and animals. Chronic exposures cause loss of weight, anemia, dysproteinemia, proteinuria increased aminoaciduria, emphysema and bone lesions. It has been suggested more recently by American investigators that the steady accumulation of cadmium in the kidney with age may play a role in the development of hypertension and atherosclerotic heart disease. The biochemical mechanisms underlying those phenomena are not well understood. In particular, the mechanism of cadmium-induced anemia was almost completely unclear when this investigation was started. Although since then some hitherto unknown facts have been revealed, the problem of cadmium-induced anemia is still far from being elucidated. The whole problem is complex and may be approached from many different angles. In this investigation attention has been concentrated on the biosynthetic pathway of porphyrins in both in vitro and in vivo experiments. In addition, some aspects of protein metabolism have been added. Heavy emphasis has been put on the interdependence of cadmium with some other metals as zinc, copper, and lead. As pure industrial cadmium exposure cases were not available, the work was limited· to experiments on animals. As a matter of fact, Polish workers engaged in cadmium production are liable to a multi-metal exposure with a heavy impact on anemia causing agent such as lead. The ultimate aim of this investigation was to find--in accordance with modern trends in industrial toxicology--one or more pretoxic test which would facilitate the early diagnosis of imminent clinical intoxication syndromes.
• Subjects:
  Accidents, Occupational Computers Electricity Electromagnetic Fields Occupational Health Radiation Safety
• Keywords:
  Anemia Animal Studies Cadmium Chronic Exposure Toxicology
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-32
• NIOSHTIC Number:
  nn:20057274
• Citation:
  Proceedings of the Special Foreign Currency Program Symposium, October 1970, Dubrovnik, Yugoslavia. Henschel A ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Health Services and Mental Health Administration, National Institute for Occupational Safety and Health, 1970 Oct; :1-32
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9)
• Editor(s):
  Henschel A
• Federal Fiscal Year:
  1971
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the Special Foreign Currency Program Symposium, October 1970, Dubrovnik, Yugoslavia
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b492755f38cc62e2127478d8eb24d33d6715a63a6a7841915df2723abb7268724554e374ae2b1225e1287f33cc7e1231aec362f6c1fda7dd0568a11064b56a4e
• Download URL:
  https://stacks.cdc.gov/view/cdc/181809/cdc_181809_DS1.pdf
• File Type:
  [PDF - 2.90 MB ]