Accumulation and composition of inhaled particulates in human lungs.

Details

• Personal Author:
  Ohta Y
• Description:
  An analysis was made of particulate matter isolated from autopsied human lungs of deceased residents of the Tokyo metropolitan area, to establish a data base of elemental and toxic materials accumulated in lungs. Upper left lung lobes from 108 persons with no history of lung disease were studied. Black powder residues separated from lung tissue were analyzed by scanning and transmission electron microscopy with energy dispersive x-ray analysis, neutron activation, elemental analysis, electron spin resonance and x-ray diffraction. Mutagenicity of black deposits was assessed by the Ames test. Primary pathological results were chronic bronchiolitis, emphysema and pavement epithelium metaplasia and were related to heavy cigarette smoking. There was a significant positive correlation of particulate deposition rate with age. Various elements of natural and artificial environmental origin were detected. A high level of chromium (7440473) was noted in tissue from a chromium worker exposed to hexavalent chromium. Average total carbon (7440440) content was 55 weight percent and did not differ between smokers and nonsmokers. Average elemental carbon content was 39 weight percent. Carbon free radicals were detected and attributed to smoking and soot. Mutagenicity tests revealed one sample positive for both Salmonella-typhimurium (TA-98) and (TA- 100), while three samples were positive for (TA-98) only. Alpha- quartz (14808607) was observed in 55 samples, and asbestos (1332214) fibers were observed in three of ten samples analyzed. The latter were identified as chrysotile (12001295) in one sample and tremolite (77536686) and crocidolite (12001284) in another. The author concludes that multiple factors, including cigarette smoking, contribute to pulmonary disease due to environmental substances. These results may be useful in determining factors involved in lung disease caused by deposited particles.
• Subjects:
  Accidents, Occupational Air Pollutants, Occupational Butanones Chemistry Occupational Health Safety Solvents
• Keywords:
  Airborne Particles Autopsies Histopathology Humans Lung Tissue Mutagenesis Qualitative Analysis Quantitative Analysis
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  726-729
• NIOSHTIC Number:
  nn:00198860
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Sep; (Pt I):726-729
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3) ; Carbon (CAS RN 7440-44-0) ; Quartz (SiO2) (CAS RN 14808-60-7) ; Asbestos (CAS RN 1332-21-4) ; Chrysotile (CAS RN 12001-29-5) ; Tremolite asbestos (CAS RN 77536-68-6) ; Crocidolite asbestos (CAS RN 12001-28-4)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  False
• Part Number:
  I
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bcb83674aafa5877f9f10537b3125d34ea0c34c28f4f201f78a3c56595fde7990a97d8c23284420b80b1018acaddd859e69e351ec16116c879ba47a718264015
• Download URL:
  https://stacks.cdc.gov/view/cdc/180692/cdc_180692_DS1.pdf
• File Type:
  [PDF - 146.50 KB ]