The different biological effects of dusts applicated intratracheally separately or in mixtures in rats.

Details

• Personal Author:
  Breining H ; Ehm W ; Rosmanith J
• Description:
  In order to investigate the behavior of dusts in mixtures, the rat intratracheal test was utilized to examine anhydrite (14798040), cadmium-sulfide (1306236), and titanium-dioxide (13463677) dusts separately or in mixtures with Doorentruper quartz (14808607) or polyvinylpyridine-N-oxide (9045812) (PVNO). In the various mixtures PVNO demonstrated variable behavior, such as inhibitory with quartz and stimulatory with cadmium-sulfide. A similar behavior was noted with anhydrite: it acted as an inhibitor of quartz whereas with the bounding catalyzer, a mixture of iron (7439896) and potassium- sulfide (1312738), no inhibition was noted. The physical characteristics of the dust mixtures used indicated that the act of mixing imparted to the dusts properties which cannot be calculated on an additive basis. The authors state that the mixture will thus react totally differently from the individual dusts applied separately. These observations result in the suggestion that there may be a general principal here, namely that each dust can demonstrate different behavior in different dust mixtures.
• Subjects:
  Accidents, Occupational Environmental Pollution Occupational Health Paint Phosphoric Acids Radiography Safety
• Keywords:
  Cell Function Dust Exposure Dust Inhalation Laboratory Animals Lung Cells Lung Function Mineral Dusts Respiratory System Disorders Silica Dusts
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  547-553
• NIOSHTIC Number:
  nn:00198461
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Sep; (Part I):547-553
• CAS Registry Number:
  Anhydrite (CAS RN 14798-04-0) ; Cadmium sulfide (CAS RN 1306-23-6) ; Titania (CAS RN 13463-67-7) ; Quartz (SiO2) (CAS RN 14808-60-7) ; Poly(vinylpyridine N-oxide) (CAS RN 9045-81-2) ; Iron (CAS RN 7439-89-6) ; Potassium sulfide (CAS RN 1312-73-8)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  False
• Part Number:
  I
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ca8aa04aba40b822f9d07c7e4468508d2fb87523321eab04277f5b1ddd7742d26f9080b4fda9276014bdca151362db024e0205543b6a122e6e377a93013cb01d
• Download URL:
  https://stacks.cdc.gov/view/cdc/180524/cdc_180524_DS1.pdf
• File Type:
  [PDF - 256.82 KB ]