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Molecular Model of Prion Transmission to Humans
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Dec 2009
Source: Emerg Infect Dis. 15(12):2013-2016. -
Alternative Title:Emerg Infect Dis
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Description:To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.
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