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Oseltamivir-Resistant Influenza Virus A (H1N1), Europe, 2007–08 Season

Published Date:

Apr 2009

Source:

Emerg Infect Dis. 15(4):552-560.

[PDF-395.61 KB]

Details:

Personal Authors:

Meijer, Adam ; Lackenby, Angie ; Hungnes, Olav ; Lina, Bruno ; van der Werf, Sylvie ; ... More ▼

Corporate Authors:

on behalf of the European Influenza Surveillance Scheme

Keywords:

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Description:

In Europe, the 2007-08 winter season was dominated by influenza virus A (H1N1) circulation through week 7, followed by influenza B virus from week 8 onward. Oseltamivir-resistant influenza viruses A (H1N1) (ORVs) with H275Y mutation in the neuraminidase emerged independently of drug use. By country, the proportion of ORVs ranged from 0% to 68%, with the highest proportion in Norway. The average weighted prevalence of ORVs across Europe increased gradually over time, from near 0 in week 40 of 2007 to 56% in week 19 of 2008 (mean 20%). Neuraminidase genes of ORVs possessing the H275Y substitution formed a homogeneous subgroup closely related to, but distinguishable from, those of oseltamivir-sensitive influenza viruses A (H1N1). Minor variants of ORVs emerged independently, indicating multiclonal ORVs. Overall, the clinical effect of ORVs in Europe, measured by influenza-like illness or acute respiratory infection, was unremarkable and consistent with normal seasonal activity.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

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