<!DOCTYPE article
PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD with MathML3 v1.3 20210610//EN" "JATS-archivearticle1-3-mathml3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="1.3" xml:lang="en" article-type="research-article"><?properties manuscript?><processing-meta base-tagset="archiving" mathml-version="3.0" table-model="xhtml" tagset-family="jats"><restricted-by>pmc</restricted-by></processing-meta><front><journal-meta><journal-id journal-id-type="nlm-journal-id">101495376</journal-id><journal-id journal-id-type="pubmed-jr-id">36818</journal-id><journal-id journal-id-type="nlm-ta">Psychol Trauma</journal-id><journal-id journal-id-type="iso-abbrev">Psychol Trauma</journal-id><journal-title-group><journal-title>Psychological trauma : theory, research, practice and policy</journal-title></journal-title-group><issn pub-type="ppub">1942-9681</issn><issn pub-type="epub">1942-969X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">34166045</article-id><article-id pub-id-type="pmc">8702580</article-id><article-id pub-id-type="doi">10.1037/tra0001049</article-id><article-id pub-id-type="manuscript">NIHMS1738433</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Scoring the Life Events Checklist: Comparison of Three Scoring Methods</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Weis</surname><given-names>Carissa N.</given-names></name><xref rid="A1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Webb</surname><given-names>E. Kate</given-names></name><xref rid="A1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Stevens</surname><given-names>Sarah K.</given-names></name><xref rid="A2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Larson</surname><given-names>Christine L.</given-names></name><xref rid="A1" ref-type="aff">a</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>deRoon-Cassini</surname><given-names>Terri A.</given-names></name><xref rid="A3" ref-type="aff">c</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>a</label>University of Wisconsin&#x02014;Milwaukee, Department of Psychology, Milwaukee, WI, USA</aff><aff id="A2"><label>b</label>University of California&#x02014;Irvine, Department of Psychology, Irvine, CA, USA</aff><aff id="A3"><label>c</label>Medical College of Wisconsin, Department of Surgery, Division of Trauma &#x00026; Acute Care Surgery, Milwaukee, WI, USA</aff><author-notes><corresp id="CR1"><bold>Corresponding Author:</bold> Carissa Weis, MS, Department of Psychology, University of Wisconsin &#x02013; Milwaukee, 2441 E Hartford Ave, Milwaukee, WI 53201, <email>cnweis@uwm.edu</email></corresp><fn id="FN1"><label>*</label><p id="P1">denotes shared senior authorship</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>9</month><year>2021</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2022</year></pub-date><pub-date pub-type="epub"><day>24</day><month>6</month><year>2021</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2023</year></pub-date><volume>14</volume><issue>4</issue><fpage>714</fpage><lpage>720</lpage><abstract id="ABS1"><sec id="S1"><title>Objective:</title><p id="P2">Prior trauma history is a reliable and robust risk predictor for PTSD development. Obtaining an accurate measurement of prior trauma history is critical in research of trauma-related outcomes. The Life Events Checklist (LEC) is a widely used self-report measure of trauma history that categorizes events by the proximity to trauma exposure; however, the field has published multiple scoring methods when assessing the LEC. Herein, we propose a novel scoring procedure in which total scores from the LEC are weighted according to the proximity of trauma exposure with &#x0201c;experienced&#x0201d; events weighted most and &#x0201c;learned about&#x0201d; events weighted least.</p></sec><sec id="S2"><title>Method:</title><p id="P3">The utility of this weighted score was assessed in two traumatically-injured civilian samples and compared against previously published scoring methods, including a non-weighted score including all events experienced, witnessed, and learned about, as well as a score consisting of only experienced events.</p></sec><sec id="S3"><title>Results:</title><p id="P4">Results indicated the standard total score was most reliable, followed by the weighted score. The experienced events score was least reliable, but the best predictor of future PTSD symptoms.</p></sec><sec id="S4"><title>Conclusions:</title><p id="P5">One method to balance the predictive strength of experienced events and the excellent reliability of a total LEC score, is to adopt the newly proposed weighted score. Future use of this weighted scoring method can provide a comprehensive estimate of lifetime trauma exposure while still emphasizing the direct proximity of experienced events compared to other degrees of exposure.</p></sec></abstract><kwd-group><kwd>prior trauma history</kwd><kwd>Life Events Checklist</kwd><kwd>PTSD</kwd><kwd>trauma outcomes</kwd></kwd-group></article-meta></front><body><sec id="S5"><title>Introduction</title><p id="P6">Trauma exposure is exceedingly prevalent; an estimated 70% of individuals will experience at least one traumatic event in their lives (<xref rid="R27" ref-type="bibr">Kessler et al., 2017</xref>; <xref rid="R45" ref-type="bibr">U.S. Department of Veterans Affairs, 2019</xref>). While most individuals are resilient in response to trauma, lifetime prevalence rates indicate a substantial subset (5-9%) go on to develop post-traumatic stress disorder (PTSD: <xref rid="R2" ref-type="bibr">American Psychiatric Association, 2013</xref>; <xref rid="R10" ref-type="bibr">Cloitre et al., 2019</xref>; <xref rid="R27" ref-type="bibr">Kessler et al., 2017</xref>; <xref rid="R28" ref-type="bibr">Kilpatrick et al., 2013</xref>; <xref rid="R43" ref-type="bibr">Thompson et al., 2018</xref>; <xref rid="R49" ref-type="bibr">Wisco et al., 2014</xref>; <xref rid="R50" ref-type="bibr">Wu et al., 2013</xref>). A vast body of literature has shown that repeated trauma exposure (<xref rid="R13" ref-type="bibr">Delahanty, 2006</xref>; <xref rid="R14" ref-type="bibr">Delahanty et al., 2003</xref>; <xref rid="R22" ref-type="bibr">Jakob et al., 2017</xref>; <xref rid="R23" ref-type="bibr">Karam et al., 2014</xref>; <xref rid="R26" ref-type="bibr">Kessler et al., 2018</xref>; <xref rid="R30" ref-type="bibr">Lee &#x00026; Park, 2018</xref>; <xref rid="R32" ref-type="bibr">Milligan-Saville et al., 2018</xref>; <xref rid="R34" ref-type="bibr">Ozer et al., 2003</xref>; <xref rid="R42" ref-type="bibr">Shalev et al., 2019</xref>; <xref rid="R50" ref-type="bibr">Wu et al., 2013</xref>), and previous trauma history significantly increases risk of PTSD development (<xref rid="R22" ref-type="bibr">Jakob et al., 2017</xref>; <xref rid="R26" ref-type="bibr">R C Kessler et al., 2018</xref>; <xref rid="R37" ref-type="bibr">Reger et al., 2019</xref>; <xref rid="R42" ref-type="bibr">Shalev et al., 2019</xref>). Therefore, reliable and accurate measurement of prior trauma history is important in research of trauma-related outcomes in order to assess its specific contributions to PTSD vulnerability.</p><p id="P7">The Life Events Checklist (LEC) is a widely used self-report measure of prior trauma history that was designed to accompany the Clinician Administered PTSD Scale (CAPS) in aiding PTSD diagnosis (<xref rid="R17" ref-type="bibr">Gray et al., 2004</xref>; <xref rid="R46" ref-type="bibr">Weathers et al., 2013</xref>). The LEC consists of 17 questions about various traumatic events a person may have experienced, each asked in reference to the degree of (i.e., proximity to) exposure (i.e. experienced, witnessed, learned about). The LEC has demonstrated good test-retest reliability (item-level Kappa&#x02019;s &#x0003e; 0.50) and strong convergence of total scores with validated PTSD symptom severity measures (Pearson <italic toggle="yes">r</italic>&#x02019;s ranging from 0.34-0.48) including the Traumatic Life Events Questionnaire (TLEQ; <xref rid="R29" ref-type="bibr">Kubany et al., 2000</xref>), PTSD Checklist (PCL; <xref rid="R6" ref-type="bibr">Blevins et al., 2015</xref>), and CAPS (<xref rid="R17" ref-type="bibr">Gray et al., 2004</xref>; <xref rid="R46" ref-type="bibr">Weathers et al., 2013</xref>). In non-clinical samples, the LEC also has moderate test-retest reliability, with events that were directly experienced being the most reliably reported (<xref rid="R35" ref-type="bibr">Pugach et al., 2020</xref>).</p><p id="P8">By sorting traumatic events according to proximity, the LEC is able to capture a myriad of traumatic experiences that may have differential impacts on an individual (<xref rid="R5" ref-type="bibr">Benfer et al., 2018</xref>; <xref rid="R21" ref-type="bibr">Irish et al., 2008</xref>; <xref rid="R24" ref-type="bibr">Kelley et al., 2009</xref>; <xref rid="R25" ref-type="bibr">Keshet et al., 2019</xref>). However, the scoring protocol instructs all endorsed items across all exposure types to be summed together to generate a total score (<xref rid="R17" ref-type="bibr">Gray et al., 2004</xref>). This method of scoring does not account for the notion that proximity of exposure may carry different risk conferral for PTSD than others (<xref rid="R41" ref-type="bibr">Sareen, 2014</xref>). For example, sexual assault has been shown to be more traumatizing (i.e. greater PTSD symptom severity) than the sudden death of a loved one (<xref rid="R5" ref-type="bibr">Benfer et al., 2018</xref>; <xref rid="R24" ref-type="bibr">Kelley et al., 2009</xref>; <xref rid="R25" ref-type="bibr">Keshet et al., 2019</xref>). Although researchers have published manuscripts utilizing this total scoring method (<xref rid="R4" ref-type="bibr">Belleau et al., 2020</xref>; <xref rid="R9" ref-type="bibr">Chung et al., 2014</xref>; <xref rid="R19" ref-type="bibr">Heir et al., 2019</xref>; <xref rid="R31" ref-type="bibr">Letica-Crepulja et al., 2020</xref>; <xref rid="R47" ref-type="bibr">Weis et al., 2018</xref>; <xref rid="R48" ref-type="bibr">White et al., 2015</xref>), others have attempted to capture the notion that proximity to the trauma is an important consideration (e.g. <xref rid="R33" ref-type="bibr">M&#x000f8;ller et al., 2020</xref>; <xref rid="R37" ref-type="bibr">Reger et al., 2019</xref>). The LEC can also be scored to &#x0201c;count&#x0201d; only the endorsed experienced items (e.g. <xref rid="R33" ref-type="bibr">M&#x000f8;ller et al., 2020</xref>; <xref rid="R37" ref-type="bibr">Reger et al., 2019</xref>), if those events really do carry the greatest risk, though this approach has not been validated (<xref rid="R32" ref-type="bibr">Milligan-Saville et al., 2018</xref>). Furthermore, only considering the events directly experienced by an individual does not capture the trauma load of other forms of exposure assessed in the LEC.</p><p id="P9">We have framed the proposed method in the context of evidence suggesting that all trauma types, even events that are learned about, are important when assessing cumulative life trauma (<xref rid="R3" ref-type="bibr">Baker et al., 2020</xref>; <xref rid="R11" ref-type="bibr">Conrad et al., 2017</xref>; <xref rid="R40" ref-type="bibr">Sacchi et al., 2020</xref>) as well as the substantial evidence that direct proximity to (i.e., &#x0201c;experienced&#x0201d;) trauma bestows additional risk (<xref rid="R5" ref-type="bibr">Benfer et al., 2018</xref>; <xref rid="R24" ref-type="bibr">Kelley et al., 2009</xref>; <xref rid="R25" ref-type="bibr">Keshet et al., 2019</xref>; <xref rid="R32" ref-type="bibr">Milligan-Saville et al., 2018</xref>; <xref rid="R36" ref-type="bibr">Qi et al., 2016</xref>; <xref rid="R37" ref-type="bibr">Reger et al., 2019</xref>). Therefore, in order to harmoniously bridge these two conceptualizations and fully capture the utility of the LEC, the current report proposes an alternative scoring procedure for the LEC to measure prior trauma history. In two traumatically injured clinical samples, we evaluated whether a total weighted LEC score, according to proximity of trauma exposure, may better capture the relationship between previous trauma history and risk of PTSD compared to the unweighted total and experienced events only score.</p></sec><sec id="S6"><title>Method</title><sec id="S7"><title>Participants</title><p id="P10">Both samples in the current study included participants recruited from the urban Level 1 Trauma Center in southeastern Wisconsin who were being treated for injuries. For sample characteristics see <xref rid="T1" ref-type="table">Table 1</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplemental Table 2</xref>.</p><sec id="S8"><title>Imaging Study on Trauma &#x00026; Resilience (iSTAR).</title><p id="P11">The first sample was derived from a large longitudinal study designed to identify acute post-trauma risk factors of PTSD development using biospecimen, self-report measures, cognitive and behavioral assessments, and magnetic resonance imaging (MRI) to assess structural and functional brain data (study name: iSTAR). Individuals were eligible for the study if they had recently been discharged from the ED of a Level 1 Trauma Center, and were excluded for comorbid substance abuse, psychosis, and moderate to severe traumatic brain injury (TBI) (See <xref rid="SD1" ref-type="supplementary-material">Supplemental Table 1</xref> for full inclusion/exclusion criteria). Enrolled participants were asked to complete seven study visits: two weeks after their injury on two consecutive days (&#x0201c;Day 1&#x0201d; and &#x0201c;Day 2&#x0201d;), and 3-, 6-, 12-, 18-, and 24-months post-injury. A majority of the injuries were caused by non-assaultive trauma (i.e. accidents) such as motor vehicle collisions (MVC), falls, and recreational injuries (78%), while the remaining 22% were injured due to assaultive trauma. Relevant to the current study, 215 participants completed self-report measures (see <xref rid="S10" ref-type="sec">Measures</xref>) at Day 1, of which 191 were retained in the study and completed measures at 6-month follow up.</p></sec><sec id="S9"><title>Study on Trauma &#x00026; Resilience (STAR 1.0).</title><p id="P12">The second sample was from a separate longitudinal study also aimed at identifying post-trauma risk factors of PTSD development using biospecimens, genetics, and self-report measures (study name: STAR 1.0). Participants were asked to complete three study visits: in-hospital (baseline, BL), 3-months, and 6-months post-injury. Enrolled participants were admitted to the hospital for a single-incident traumatic injury and were excluded for active psychosis and moderate to severe TBI (See <xref rid="SD1" ref-type="supplementary-material">Supplemental Table 1</xref> for full inclusion/exclusion criteria). Relevant to the current study, 278 participants completed self-report measures at BL, of which 172 were retained and completed measures at 6-month follow up. A majority of the injuries were caused by non-assaultive trauma (67%) while the remaining 33% were injured due to assaultive trauma.</p></sec></sec><sec id="S10"><title>Measures</title><sec id="S11"><title>Life Events Checklist.</title><p id="P13">The LEC assesses occurrence of 17 major life events (e.g. natural disaster, assault, combat, life-threatening illness or injury) that a person may have experienced, witnessed, or learned about happening to someone close to them (<xref rid="R17" ref-type="bibr">Gray et al., 2004</xref>). In both samples, the LEC was collected at baseline visits, which was 2-weeks for iSTAR (average of 16 days since trauma), and within 1-week while in-hospital for STAR 1.0 (average of 2.5 days since trauma).</p><p id="P14">One way to score the LEC, commonly utilized in the literature (<xref rid="R4" ref-type="bibr">Belleau et al., 2020</xref>; <xref rid="R19" ref-type="bibr">Heir et al., 2019</xref>; <xref rid="R31" ref-type="bibr">Letica-Crepulja et al., 2020</xref>; <xref rid="R47" ref-type="bibr">Weis et al., 2018</xref>; <xref rid="R48" ref-type="bibr">White et al., 2015</xref>), is to sum all endorsed items from all exposure types to generate a total LEC score (min/max for each scale = 0-17, total score min/max = 0-51). In addition to this total score, we also totaled items endorsed as experienced only, as some researchers have chosen to do (<xref rid="R17" ref-type="bibr">Gray et al., 2004</xref>; <xref rid="R33" ref-type="bibr">M&#x000f8;ller et al.,2020</xref>; <xref rid="R37" ref-type="bibr">Reger et al., 2019</xref>).</p><p id="P15">Finally, a weighted score was developed to highlight the theorized greater traumatization from experienced events as opposed to other forms of exposure while still including all forms of exposure. Items experienced directly were weighted by a factor of 3, items witnessed weighted with a factor of 2, and items learned about were weighted with a factor of 1. After weighting, all items were summed (maximum score = 102). Greater weighted scores would therefore indicate more events experienced with closer proximity to the individual.</p><p id="P16">Thus, three separate LEC scores were calculated: experienced events only, standard total score, and a weighted score. All three LEC scores were analyzed for both samples (iSTAR, STAR 1.0).</p></sec><sec id="S12"><title>The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5).</title><p id="P17">The CAPS-5 was used to assess chronic PTSD symptoms for both samples at 6-months post-injury (<xref rid="R46" ref-type="bibr">Weathers et al., 2013</xref>). The CAPS-5 is a clinical interview consisting of 18 questions corresponding to DSM-5 PTSD symptoms. Frequency and intensity of PTSD symptoms are assessed by the interviewer and a single severity rating is designated for each item. Total symptom severity is derived from the sum of severity ratings on all questions. The interview was audio-recorded for each participant and a random selection of interviews (~20%) were reevaluated to establish excellent reliability across interviewer administration within the study (interclass correlation coefficient (ICC)=0.96, with 95% confidence interval [0.93, 0.98]). According to the CAPS-5 at 6-months, in iSTAR, 42 of 191 participants (21%) met criteria for PTSD diagnosis, and in STAR 1.0, 50 of 172 met criteria (29%).</p></sec></sec><sec id="S13"><title>Statistical Analysis</title><p id="P18">To evaluate reliability of LEC measures, pairwise correlations were calculated between all three LEC scoring methods (experienced only, total, and weighted) within each sample. In addition, to assess internal reliability of the LEC in the current samples, Cronbach&#x02019;s alpha (<xref rid="R12" ref-type="bibr">Cronbach, 1951</xref>) was calculated for all three LEC scoring methods using the &#x0201c;cronbach.alpha()&#x0201d; function in the &#x0201c;ltm&#x0201d; package in R (<xref rid="R38" ref-type="bibr">Rizopoulos, 2006</xref>).</p><p id="P19">Finally, correlations of LEC measures (BL) and CAPS-5 symptom severity (6-month) were calculated to evaluate the predictive utility of each of the LEC scoring methods. To compare the degree of correlation significance between LEC scoring methods with CAPS severity (overlapping correlations of dependent groups), Hotelling&#x02019;s <italic toggle="yes">t</italic> (<xref rid="R20" ref-type="bibr">Hotelling, 1940</xref>) was calculated between all pairwise combinations of the LEC scoring methods and the CAPS using the &#x0201c;cocor&#x0201d; package in R (<xref rid="R15" ref-type="bibr">Diedenhofen &#x00026; Musch, 2015</xref>).</p></sec></sec><sec id="S14"><title>Results</title><p id="P20">For sample characteristics see <xref rid="T1" ref-type="table">Table 1</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplemental Tables 1</xref> and <xref rid="SD1" ref-type="supplementary-material">2</xref>. There were no significant gender differences in the three LEC scoring methods for either sample. There were no gender differences in total CAPS in the iSTAR sample (<italic toggle="yes">p</italic> &#x0003e; 0.05) though females in the STAR 1.0 sample had significantly greater CAPS symptom severity (<italic toggle="yes">t</italic>(100) = &#x02212;2.02, <italic toggle="yes">p</italic> = 0.04). The sample from STAR 1.0 was significantly older than the sample in iSTAR, <italic toggle="yes">t</italic>(308) = 6.34, <italic toggle="yes">p</italic> &#x0003c; 0.01. While inclusion criteria were the same for both samples in terms of age (18-60), the STAR 1.0 sample tended to be older as there were sometimes competing health concerns resulting in their admittance to the hospital post-trauma. Age was not significantly related to CAPS symptom severity in the iSTAR sample, but in the STAR 1.0 sample, greater age was significantly related to greater CAPS symptom severity (<italic toggle="yes">t</italic>(171)= &#x02212;3.60, <italic toggle="yes">p</italic> &#x0003c; 0.01).</p><p id="P21">There were no significant differences in the scores produced by the three LEC scoring methods between the two samples (Experienced: <italic toggle="yes">t</italic>(450) = 1.06, <italic toggle="yes">p</italic> = 0.28; Total: <italic toggle="yes">t</italic>(434) = 0.89, <italic toggle="yes">p</italic> = 0.37; Weighted: <italic toggle="yes">t</italic>(438) = 0.99, <italic toggle="yes">p</italic> = 0.31). In addition, both samples had comparable CAPS symptom severity scores at 6-months, <italic toggle="yes">t</italic>(325) = &#x02212;0.10, <italic toggle="yes">p</italic> = 0.91.</p><p id="P22">First, LEC metrics were evaluated for reliability of measurement across both samples. Pairwise correlations demonstrated all three LEC measures were highly correlated with one another at baseline for both samples (all <italic toggle="yes">p</italic> &#x0003c; 0.01, <xref rid="T2" ref-type="table">Table 2</xref>).</p><p id="P23">Internal reliability results indicated experienced only scores demonstrated poor reliability for both samples (&#x003b1; &#x0003c; 0.67), while total scores demonstrated excellent reliability in both samples (&#x003b1; &#x0003e; 0.87), and weighted scores demonstrated good reliability in both samples (&#x003b1; &#x0003e; 0.83; <xref rid="T3" ref-type="table">Table 3</xref>; <xref rid="R18" ref-type="bibr">Hair, 2010</xref>).</p><p id="P24">To characterize the relationship of the three LEC scores with PTSD symptoms, all three LEC scoring methods were correlated with total CAPS symptom severity at 6-months. In the iSTAR sample, all three LEC scoring measures were highly correlated with CAPS symptom severity at 6-months (all <italic toggle="yes">p</italic> &#x0003c; 0.01). In the STAR 1.0 sample, experienced only scores at baseline were highly related to CAPS severity at 6-months (<italic toggle="yes">p</italic> &#x0003c; 0.01; <xref rid="T4" ref-type="table">Table 4</xref>).</p><p id="P25">Finally, to compare degree of correlation significance between LEC measures with CAPS severity, Hotelling&#x02019;s <italic toggle="yes">t</italic> were calculated between all pairwise combinations of the LEC measures and the CAPS. In the iSTAR sample, there were no significant differences in correlation significances for any pairwise comparisons of LEC correlations with CAPS (all <italic toggle="yes">p</italic> &#x0003e; 0.50). In the STAR 1.0 sample, total versus weighted scores yielded a significant difference in correlation significance (<italic toggle="yes">p</italic> = 0.02) such that weighted scores had a statistically more significant relationship with the CAPS than total scores. Even though the experienced LEC measure was the lone scoring method related to CAPS in the STAR 1.0 sample, the relative difference between total and weighted scores was greater than experienced versus total (<italic toggle="yes">p</italic>= 0.09) or experienced versus weighted scores (<italic toggle="yes">p</italic>= 0.21).</p></sec><sec id="S15"><title>Discussion</title><p id="P26">While exposure to previous trauma has been shown as a significant risk factor in PTSD development (<xref rid="R22" ref-type="bibr">Jakob et al., 2017</xref>; <xref rid="R26" ref-type="bibr">Kessler et al., 2018</xref>; <xref rid="R37" ref-type="bibr">Reger et al., 2019</xref>; <xref rid="R42" ref-type="bibr">Shalev et al., 2019</xref>), different scoring methods have been utilized for the Life Event Checklist (LEC), a widely used trauma exposure instrument. Therefore, the current study evaluated the reliability and validity of various LEC scoring methods and proposed a new method wherein exposure to trauma was weighted by the proximity to exposure (i.e., experienced, witnessed, learned about). In two independent traumatically-injured civilian samples, we demonstrated good reliability and validity of a novel weighted scoring method and compared it to the total and experienced only scoring methods.</p><p id="P27">Unsurprisingly, results of the reliability analysis show the weighted score is significantly and highly correlated with the standard total score and the experienced only score. The weighted score also had very good internal reliability (&#x003b1; &#x0003e; 0.83). In addition, the weighted score had better internal reliability than the experienced only score (&#x003b1; &#x0003e; 0.59), though not as high of reliability as the standard total score (&#x003b1; &#x0003e; 0.87). Of particular interest within the current study, was the validity of the weighted LEC score in predicting PTSD symptom severity. In both samples, the experienced events only score was significantly predictive of PTSD symptom severity assessed with CAPS-5 at follow-up. However, the weighted score only showed robust predictive utility with PTSD symptom severity in one sample (iSTAR). The difference in predictive utility may stem from the different natures of the samples (see <xref rid="S16" ref-type="sec">limitations</xref>).</p><p id="P28">Although the experienced only scores were most predictive of PTSD symptom severity, experienced only events had the worst reliability of the three measures. While this result underscores the well-documented significance of experienced traumatic events in risk of PTSD (<xref rid="R5" ref-type="bibr">Benfer et al., 2018</xref>; <xref rid="R21" ref-type="bibr">Irish et al., 2008</xref>; <xref rid="R24" ref-type="bibr">Kelley et al., 2009</xref>; <xref rid="R25" ref-type="bibr">Keshet et al., 2019</xref>; <xref rid="R32" ref-type="bibr">Milligan-Saville et al., 2018</xref>; <xref rid="R36" ref-type="bibr">Qi et al., 2016</xref>; <xref rid="R37" ref-type="bibr">Reger et al., 2019</xref>), it may not be the most reliable measure of trauma history; however, poor reliability could simply be due to the fewer number of items in the experienced score compared to total and weighted scores (<xref rid="R12" ref-type="bibr">Cronbach, 1951</xref>). Weak internal reliability but strong correlation with PTSD symptoms may also suggest some of the experienced events in particular were stronger predictors of PTSD than other experienced events. However, the nature of this relationship cannot be further evaluated due to the lack of event context recorded by the LEC (see <xref rid="S16" ref-type="sec">limitations</xref>).</p><p id="P29">Moreover, while the standard LEC total demonstrated the highest reliability, it does not capture the degree to which various trauma exposure types may confer PTSD risk (<xref rid="R5" ref-type="bibr">Benfer et al., 2018</xref>; <xref rid="R21" ref-type="bibr">Irish et al., 2008</xref>; <xref rid="R24" ref-type="bibr">Kelley et al., 2009</xref>; <xref rid="R25" ref-type="bibr">Keshet et al., 2019</xref>). Therefore, we have suggested an alternative method to capture the importance of experienced events in a reliable way. The weighted score emphasizes experienced events while still including the other forms of trauma exposure, and in the current study had excellent reliability over experienced events only. Of note, the weighted score is supported by research indicating that proximity of the traumatic event is a factor that confers differential risk of PTSD. However, it is important to note that is not the only factor, or perhaps even most important factor, by which risk of PTSD is conferred. Subjective interpretations and perceptions of trauma vary by individuals and are important when assessing trauma outcomes (<xref rid="R7" ref-type="bibr">Brasel et al., 2010</xref>; <xref rid="R16" ref-type="bibr">Geiger et al., 2011</xref>; <xref rid="R25" ref-type="bibr">Keshet et al., 2019</xref>). The utilization of the standard total score is also based on an assumption, that all traumatic events, regardless of proximity, impact an individual in the same way or to the same degree. Choice of a score (weighted versus standard) should be considered within the context of LEC administration, whether as a direct predictor of PTSD or as a covariate in other analyses, and with the consideration of how the underlying assumptions behind each scoring method may apply to a particular sample or research question.</p><p id="P30">A notable aspect of the current study is the inclusion of racially diverse samples. In both the iSTAR and STAR 1.0 samples 67% and 54% of participants, respectively, identified as a race other than White. While previous work has shown trauma, PTSD, and culture intersect in complex ways (<xref rid="R1" ref-type="bibr">Alegr&#x000ed;a et al., 2013</xref>; <xref rid="R8" ref-type="bibr">Chemtob, 1996</xref>; <xref rid="R44" ref-type="bibr">Ungar, 2013</xref>), in the U.S., prevalence of PTSD is one of many health disparities that varies by racial and ethnic groups. More specifically, several studies have demonstrated higher rates and conditional risk for PTSD for Black and African Americans when compared to Hispanics, Latinx, Asians, and Whites (<xref rid="R1" ref-type="bibr">Alegr&#x000ed;a et al., 2013</xref>; <xref rid="R39" ref-type="bibr">Roberts et al., 2011</xref>). Despite this empirical evidence, reliability of PTSD risk assessments, like the LEC, have not been appropriately evaluated in a diverse sample (<xref rid="R17" ref-type="bibr">Gray et al., 2004</xref>; <xref rid="R46" ref-type="bibr">Weathers et al., 2013</xref>). Thus, the current study adds to the literature by presenting reliability indices of various scoring methods for the LEC while utilizing a more representative trauma sample and encourages future work to include cultural considerations in study designs.</p><sec id="S16"><title>Limitations</title><p id="P31">While the current study utilized two independent samples in evaluating the reliability and validity of LEC scoring methods, there is significant overlap in the sample characteristics. The samples were recruited from the same geographic region, hospital, and trauma center (albeit in completely independent time frames), and due to similar inclusion criteria (i.e. requiring medical attention for traumatic injuries). However, the iSTAR sample were discharged from the emergency department (and therefore less severely injured) and the STAR sample were those admitted to the hospital and therefore more severely injured, providing breadth related to injury severity in a trauma sample. Despite the overlap in sample characteristics, results of the current study show separable findings in the performance of the weighted LEC score. Still, further work needs to be done to replicate the current findings in other trauma exposed as well as nonclinical (i.e. not hospitalized) samples.</p><p id="P32">Another limitation lies within the construct of the LEC. The LEC is a checklist meant to provide a general overview of an individual&#x02019;s lifetime trauma history. The LEC was not originally designed to measure the frequency, severity, duration, or the recency of an endorsed item. Although the LEC is limited in its predictive validity, as it does not provide a comprehensive overview of a person&#x02019;s lived traumatic experiences, future studies may consider including additional measures to assess more specifically how traumatic events may have impacted the participant.</p></sec><sec id="S17"><title>Conclusions</title><p id="P33">The current study demonstrated the reliability and validity of the LEC experienced only score, total score, and newly proposed weighted score. An individual&#x02019;s trauma history has been repeatedly shown to be a critical risk factor in PTSD development (<xref rid="R22" ref-type="bibr">Jakob et al., 2017</xref>; <xref rid="R26" ref-type="bibr">Kessler et al., 2018</xref>; <xref rid="R37" ref-type="bibr">Reger et al., 2019</xref>; <xref rid="R42" ref-type="bibr">Shalev et al., 2019</xref>). Though experienced events may carry greatest risk conferral of PTSD (<xref rid="R5" ref-type="bibr">Benfer et al., 2018</xref>; <xref rid="R24" ref-type="bibr">Kelley et al., 2009</xref>; <xref rid="R25" ref-type="bibr">Keshet et al., 2019</xref>), other forms of trauma exposure should not be discarded at the expense of statistical power as they carry significant weight in the theory that accumulating traumas increase risk of PTSD development (<xref rid="R23" ref-type="bibr">Karam et al., 2014</xref>). The current proposal of a weighted LEC scoring method provides a balance of predictive strength and history completeness when evaluating a person&#x02019;s prior trauma history and offers an alternative assumption of how proximity of trauma may confer risk of PTSD. Nonetheless further validation of this metric is warranted through application in other trauma samples from different geographic regions and backgrounds.</p></sec></sec><sec sec-type="supplementary-material" id="SM1"><title>Supplementary Material</title><supplementary-material id="SD1" position="float" content-type="local-data"><label>Supplemental Material</label><media xlink:href="NIHMS1738433-supplement-Supplemental_Material.pdf" id="d64e681" position="anchor"/></supplementary-material></sec></body><back><ack id="S18"><title>Financial Disclosures:</title><p id="P35">Support for the research, authorship, and/or publication of this article include the following: a NIH grant R01-M1H106574 (PI: Larson) and a Medical College of Wisconsin CTSI Pilot Award (PI: deRoon-Cassini). E.K.W is supported by the National Center for Advancing Translational Sciences, National Institutes of Health (TL1TR001437). The content is solely the responsibility of the author(s) and does not necessarily represent the official views of the NIH.</p></ack><ref-list><title>References</title><ref id="R1"><mixed-citation publication-type="journal"><name><surname>Alegr&#x000ed;a</surname><given-names>M</given-names></name>, <name><surname>Fortuna</surname><given-names>LR</given-names></name>, <name><surname>Lin</surname><given-names>JY</given-names></name>, <name><surname>Norris</surname><given-names>FH</given-names></name>, <name><surname>Gao</surname><given-names>S</given-names></name>, <name><surname>Takeuchi</surname><given-names>DT</given-names></name>, <name><surname>Jackson</surname><given-names>JS</given-names></name>, <name><surname>Shrout</surname><given-names>PE</given-names></name>, &#x00026; <name><surname>Valentine</surname><given-names>A</given-names></name> (<year>2013</year>). <article-title>Prevalence, Risk, and Correlates of Posttraumatic Stress Disorder Across Ethnic and Racial Minority Groups in the United States</article-title>: <source>Medical Care</source>, <volume>51</volume>(<issue>12</issue>), <fpage>1114</fpage>&#x02013;<lpage>1123</lpage>. <pub-id pub-id-type="doi">10.1097/MLR.0000000000000007</pub-id><pub-id pub-id-type="pmid">24226308</pub-id></mixed-citation></ref><ref id="R2"><mixed-citation publication-type="book"><collab>American Psychiatric Association</collab>. (<year>2013</year>). <source>Diagnostic and Statistical Manual of Mental Disorders, 5th Edition: DSM-5</source> (<edition>5</edition> edition). <publisher-name>American Psychiatric Publishing</publisher-name>.</mixed-citation></ref><ref id="R3"><mixed-citation publication-type="journal"><name><surname>Baker</surname><given-names>DE</given-names></name>, <name><surname>Hill</surname><given-names>M</given-names></name>, <name><surname>Chamberlain</surname><given-names>K</given-names></name>, <name><surname>Hurd</surname><given-names>L</given-names></name>, <name><surname>Karlsson</surname><given-names>M</given-names></name>, <name><surname>Zielinski</surname><given-names>M</given-names></name>, <name><surname>Calvert</surname><given-names>M</given-names></name>, &#x00026; <name><surname>Bridges</surname><given-names>AJ</given-names></name> (<year>2020</year>). <article-title>Interpersonal vs. Non-Interpersonal Cumulative Traumas and Psychiatric Symptoms in Treatment-Seeking Incarcerated Women</article-title>. <source>Journal of Trauma &#x00026; Dissociation</source>, <fpage>1</fpage>&#x02013;<lpage>16</lpage>. <pub-id pub-id-type="doi">10.1080/15299732.2020.1760172</pub-id></mixed-citation></ref><ref id="R4"><mixed-citation publication-type="journal"><name><surname>Belleau</surname><given-names>EL</given-names></name>, <name><surname>Ehret</surname><given-names>LE</given-names></name>, <name><surname>Hanson</surname><given-names>JL</given-names></name>, <name><surname>Brasel</surname><given-names>KJ</given-names></name>, <name><surname>Larson</surname><given-names>CL</given-names></name>, &#x00026; <name><surname>deRoon-Cassini</surname><given-names>TA</given-names></name> (<year>2020</year>). <article-title>Amygdala functional connectivity in the acute aftermath of trauma prospectively predicts severity of posttraumatic stress symptoms</article-title>. <source>Neurobiology of Stress</source>, <volume>12</volume>, <fpage>100217</fpage>. <pub-id pub-id-type="doi">10.1016/j.ynstr.2020.100217</pub-id><pub-id pub-id-type="pmid">32435666</pub-id></mixed-citation></ref><ref id="R5"><mixed-citation publication-type="journal"><name><surname>Benfer</surname><given-names>N</given-names></name>, <name><surname>Bardeen</surname><given-names>JR</given-names></name>, <name><surname>Cero</surname><given-names>I</given-names></name>, <name><surname>Kramer</surname><given-names>LB</given-names></name>, <name><surname>Whiteman</surname><given-names>SE</given-names></name>, <name><surname>Rogers</surname><given-names>TA</given-names></name>, <name><surname>Silverstein</surname><given-names>MW</given-names></name>, &#x00026; <name><surname>Weathers</surname><given-names>FW</given-names></name> (<year>2018</year>). <article-title>Network models of posttraumatic stress symptoms across trauma types</article-title>. <source>Journal of Anxiety Disorders</source>, <volume>58</volume>, <fpage>70</fpage>&#x02013;<lpage>77</lpage>. <pub-id pub-id-type="doi">10.1016/j.janxdis.2018.07.004</pub-id><pub-id pub-id-type="pmid">30055470</pub-id></mixed-citation></ref><ref id="R6"><mixed-citation publication-type="journal"><name><surname>Blevins</surname><given-names>CA</given-names></name>, <name><surname>Weathers</surname><given-names>FW</given-names></name>, <name><surname>Davis</surname><given-names>MT</given-names></name>, <name><surname>Witte</surname><given-names>TK</given-names></name>, &#x00026; <name><surname>Domino</surname><given-names>JL</given-names></name> (<year>2015</year>). <article-title>The Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5): Development and Initial Psychometric Evaluation</article-title>. <source>Journal of Traumatic Stress</source>, <volume>28</volume>(<issue>6</issue>), <fpage>489</fpage>&#x02013;<lpage>498</lpage>. <pub-id pub-id-type="doi">10.1002/jts.22059</pub-id> [doi]<pub-id pub-id-type="pmid">26606250</pub-id></mixed-citation></ref><ref id="R7"><mixed-citation publication-type="journal"><name><surname>Brasel</surname><given-names>KJ</given-names></name>, <name><surname>deRoon-Cassini</surname><given-names>T</given-names></name>, &#x00026; <name><surname>Bradley</surname><given-names>CT</given-names></name> (<year>2010</year>). <article-title>Injury Severity and Quality of Life: Whose Perspective Is Important?</article-title>: <source>The Journal of Trauma: Injury, Infection, and Critical Care</source>, <volume>68</volume>(<issue>2</issue>), <fpage>263</fpage>&#x02013;<lpage>268</lpage>. <pub-id pub-id-type="doi">10.1097/TA.0b013e3181caa58f</pub-id></mixed-citation></ref><ref id="R8"><mixed-citation publication-type="book"><name><surname>Chemtob</surname><given-names>CM</given-names></name> (<year>1996</year>). <part-title>Posttraumatic stress disorder, trauma, and culture</part-title>. In <source>International review of psychiatry</source>, Vol. <volume>2</volume>. (pp. <fpage>257</fpage>&#x02013;<lpage>292</lpage>). <publisher-name>American Psychiatric Association</publisher-name>.</mixed-citation></ref><ref id="R9"><mixed-citation publication-type="journal"><name><surname>Chung</surname><given-names>Y</given-names></name>, <name><surname>Kim</surname><given-names>NH</given-names></name>, <name><surname>Kim</surname><given-names>D</given-names></name>, <name><surname>Bae</surname><given-names>JH</given-names></name>, <name><surname>Kwon</surname><given-names>JS</given-names></name>, <name><surname>Jang</surname><given-names>JH</given-names></name>, <name><surname>Jung</surname><given-names>WH</given-names></name>, <name><surname>Kim</surname><given-names>SH</given-names></name>, <name><surname>Kim</surname><given-names>JK</given-names></name>, <name><surname>Oh</surname><given-names>DH</given-names></name>, <name><surname>Shin</surname><given-names>D-J</given-names></name>, &#x00026; <name><surname>Cho</surname><given-names>K-I</given-names></name> (<year>2014</year>). <article-title>The Psychological Characteristics and Functional Magnetic Resonance Imaging Findings in Firefighters with Partial Posttraumatic Stress Disorder and the Effect of Treatment by Using Eye Movement Desensitization and Reprocessing</article-title>. <source>Journal of Korean Neuropsychiatric Association</source>, <volume>53</volume>(<issue>2</issue>), <fpage>122</fpage>. <pub-id pub-id-type="doi">10.4306/jknpa.2014.53.2.122</pub-id></mixed-citation></ref><ref id="R10"><mixed-citation publication-type="journal"><name><surname>Cloitre</surname><given-names>M</given-names></name>, <name><surname>Hyland</surname><given-names>P</given-names></name>, <name><surname>Bisson</surname><given-names>JI</given-names></name>, <name><surname>Brewin</surname><given-names>CR</given-names></name>, <name><surname>Roberts</surname><given-names>NP</given-names></name>, <name><surname>Karatzias</surname><given-names>T</given-names></name>, &#x00026; <name><surname>Shevlin</surname><given-names>M</given-names></name> (<year>2019</year>). <article-title>ICD-11 Posttraumatic Stress Disorder and Complex Posttraumatic Stress Disorder in the United States: A Population-Based Study</article-title>. <source>Journal of Traumatic Stress</source>, <volume>32</volume>(<issue>6</issue>), <fpage>833</fpage>&#x02013;<lpage>842</lpage>. <pub-id pub-id-type="doi">10.1002/jts.22454</pub-id><pub-id pub-id-type="pmid">31800131</pub-id></mixed-citation></ref><ref id="R11"><mixed-citation publication-type="journal"><name><surname>Conrad</surname><given-names>D</given-names></name>, <name><surname>Wilker</surname><given-names>S</given-names></name>, <name><surname>Pfeiffer</surname><given-names>A</given-names></name>, <name><surname>Lingenfelder</surname><given-names>B</given-names></name>, <name><surname>Ebalu</surname><given-names>T</given-names></name>, <name><surname>Lanzinger</surname><given-names>H</given-names></name>, <name><surname>Elbert</surname><given-names>T</given-names></name>, <name><surname>Kolassa</surname><given-names>I-T</given-names></name>, &#x00026; <name><surname>Kolassa</surname><given-names>S</given-names></name> (<year>2017</year>). <article-title>Does trauma event type matter in the assessment of traumatic load?</article-title>
<source>European Journal of Psychotraumatology</source>, <volume>8</volume>(<issue>1</issue>), <fpage>1344079</fpage>. <pub-id pub-id-type="doi">10.1080/20008198.2017.1344079</pub-id><pub-id pub-id-type="pmid">28804594</pub-id></mixed-citation></ref><ref id="R12"><mixed-citation publication-type="journal"><name><surname>Cronbach</surname><given-names>LJ</given-names></name> (<year>1951</year>). <article-title>Coefficient alpha and the internal structure of tests</article-title>. <source>Psychometrika</source>, <volume>16</volume>(<issue>3</issue>), <fpage>297</fpage>&#x02013;<lpage>334</lpage>. <pub-id pub-id-type="doi">10.1007/BF02310555</pub-id></mixed-citation></ref><ref id="R13"><mixed-citation publication-type="journal"><name><surname>Delahanty</surname><given-names>DL</given-names></name> (<year>2006</year>). <article-title>Predicting PTSD Prospectively Based on Prior Trauma History and Immediate Biological Responses</article-title>. <source>Annals of the New York Academy of Sciences</source>, <volume>1071</volume>(<issue>1</issue>), <fpage>27</fpage>&#x02013;<lpage>40</lpage>. <pub-id pub-id-type="doi">10.1196/annals.1364.003</pub-id><pub-id pub-id-type="pmid">16891559</pub-id></mixed-citation></ref><ref id="R14"><mixed-citation publication-type="journal"><name><surname>Delahanty</surname><given-names>Douglas L</given-names></name>, <name><surname>Raimonde</surname><given-names>AJ</given-names></name>, <name><surname>Spoonster</surname><given-names>E</given-names></name>, &#x00026; <name><surname>Cullado</surname><given-names>M</given-names></name> (<year>2003</year>). <article-title>Injury severity, prior trauma history, urinary cortisol levels, and acute PTSD in motor vehicle accident victims</article-title>. <source>Journal of Anxiety Disorders</source>, <volume>17</volume>(<issue>2</issue>), <fpage>149</fpage>&#x02013;<lpage>164</lpage>. <pub-id pub-id-type="doi">10.1016/S0887-6185(02)00185-8</pub-id><pub-id pub-id-type="pmid">12614659</pub-id></mixed-citation></ref><ref id="R15"><mixed-citation publication-type="journal"><name><surname>Diedenhofen</surname><given-names>B</given-names></name>, &#x00026; <name><surname>Musch</surname><given-names>J</given-names></name> (<year>2015</year>). <article-title>cocor: A Comprehensive Solution for the Statistical Comparison of Correlations</article-title>. <source>PLOS ONE</source>, <volume>10</volume>(<issue>4</issue>), <fpage>e0121945</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0121945</pub-id><pub-id pub-id-type="pmid">25835001</pub-id></mixed-citation></ref><ref id="R16"><mixed-citation publication-type="journal"><name><surname>Geiger</surname><given-names>AA</given-names></name>, <name><surname>deRoon-Cassini</surname><given-names>T</given-names></name>, &#x00026; <name><surname>Brasel</surname><given-names>KJ</given-names></name> (<year>2011</year>). <article-title>Considering the Patient&#x02019;s Perspective in the Injury Severity Score</article-title>. <source>Journal of Surgical Research</source>, <volume>170</volume>(<issue>1</issue>), <fpage>133</fpage>&#x02013;<lpage>138</lpage>. <pub-id pub-id-type="doi">10.1016/j.jss.2011.03.026</pub-id></mixed-citation></ref><ref id="R17"><mixed-citation publication-type="journal"><name><surname>Gray</surname><given-names>MJ</given-names></name>, <name><surname>Litz</surname><given-names>BT</given-names></name>, <name><surname>Hsu</surname><given-names>JL</given-names></name>, &#x00026; <name><surname>Lombardo</surname><given-names>TW</given-names></name> (<year>2004</year>). <article-title>Psychometric properties of the life events checklist</article-title>. <source>Assessment</source>, <volume>11</volume>(<issue>4</issue>), <fpage>330</fpage>&#x02013;<lpage>341</lpage>. <pub-id pub-id-type="doi">10.1177/L073191104269954</pub-id><pub-id pub-id-type="pmid">15486169</pub-id></mixed-citation></ref><ref id="R18"><mixed-citation publication-type="book"><name><surname>Hair</surname><given-names>JF</given-names></name> (Ed.). (<year>2010</year>). <source>Multivariate data analysis</source> (<edition>7th</edition> ed). <publisher-name>Prentice Hall</publisher-name>.</mixed-citation></ref><ref id="R19"><mixed-citation publication-type="journal"><name><surname>Heir</surname><given-names>T</given-names></name>, <name><surname>Bonsaksen</surname><given-names>T</given-names></name>, <name><surname>Grimholt</surname><given-names>T</given-names></name>, <name><surname>Ekeberg</surname><given-names>&#x000d8;</given-names></name>, <name><surname>Skogstad</surname><given-names>L</given-names></name>, <name><surname>Lerdal</surname><given-names>A</given-names></name>, &#x00026; <name><surname>Schou-Bredal</surname><given-names>I</given-names></name> (<year>2019</year>). <article-title>Serious life events and post-traumatic stress disorder in the Norwegian population</article-title>. <source>BJPsych Open</source>, <volume>5</volume>(<issue>5</issue>), <fpage>e82</fpage>. <pub-id pub-id-type="doi">10.1192/bjo.2019.62</pub-id><pub-id pub-id-type="pmid">31506124</pub-id></mixed-citation></ref><ref id="R20"><mixed-citation publication-type="journal"><name><surname>Hotelling</surname><given-names>H</given-names></name> (<year>1940</year>). <article-title>The Selection of Variates for Use in Prediction with Some Comments on the General Problem of Nuisance Parameters</article-title>. <source>The Annals of Mathematical Statistics</source>, <volume>11</volume>(<issue>3</issue>), <fpage>271</fpage>&#x02013;<lpage>283</lpage>. <pub-id pub-id-type="doi">10.1214/aoms/1177731867</pub-id></mixed-citation></ref><ref id="R21"><mixed-citation publication-type="journal"><name><surname>Irish</surname><given-names>L</given-names></name>, <name><surname>Ostrowski</surname><given-names>SA</given-names></name>, <name><surname>Fallon</surname><given-names>W</given-names></name>, <name><surname>Spoonster</surname><given-names>E</given-names></name>, <name><surname>van Dulmen</surname><given-names>M</given-names></name>, <name><surname>Sledjeski</surname><given-names>EM</given-names></name>, &#x00026; <name><surname>Delahanty</surname><given-names>DL</given-names></name> (<year>2008</year>). <article-title>Trauma history characteristics and subsequent PTSD symptoms in motor vehicle accident victims</article-title>. <source>Journal of Traumatic Stress</source>, <volume>21</volume>(<issue>4</issue>), <fpage>377</fpage>&#x02013;<lpage>384</lpage>. <pub-id pub-id-type="doi">10.1002/jts.20346</pub-id><pub-id pub-id-type="pmid">18720390</pub-id></mixed-citation></ref><ref id="R22"><mixed-citation publication-type="journal"><name><surname>Jakob</surname><given-names>JMD</given-names></name>, <name><surname>Lamp</surname><given-names>K</given-names></name>, <name><surname>Rauch</surname><given-names>SAM</given-names></name>, <name><surname>Smith</surname><given-names>ER</given-names></name>, &#x00026; <name><surname>Buchholz</surname><given-names>KR</given-names></name> (<year>2017</year>). <article-title>The Impact of Trauma Type or Number of Traumatic Events on PTSD Diagnosis and Symptom Severity in Treatment Seeking Veterans</article-title>: <source>The Journal of Nervous and Mental Disease</source>, <volume>205</volume>(<issue>2</issue>), <fpage>83</fpage>&#x02013;<lpage>86</lpage>. <pub-id pub-id-type="doi">10.1097/NMD.0000000000000581</pub-id><pub-id pub-id-type="pmid">28129258</pub-id></mixed-citation></ref><ref id="R23"><mixed-citation publication-type="journal"><name><surname>Karam</surname><given-names>EG</given-names></name>, <name><surname>Friedman</surname><given-names>MJ</given-names></name>, <name><surname>Hill</surname><given-names>ED</given-names></name>, <name><surname>Kessler</surname><given-names>RC</given-names></name>, <name><surname>McLaughlin</surname><given-names>KA</given-names></name>, <name><surname>Petukhova</surname><given-names>M</given-names></name>, <name><surname>Sampson</surname><given-names>L</given-names></name>, <name><surname>Shahly</surname><given-names>V</given-names></name>, <name><surname>Angermeyer</surname><given-names>MC</given-names></name>, <name><surname>Bromet</surname><given-names>EJ</given-names></name>, <name><surname>de Girolamo</surname><given-names>G</given-names></name>, <name><surname>de Graaf</surname><given-names>R</given-names></name>, <name><surname>Demyttenaere</surname><given-names>K</given-names></name>, <name><surname>Ferry</surname><given-names>F</given-names></name>, <name><surname>Florescu</surname><given-names>SE</given-names></name>, <name><surname>Haro</surname><given-names>JM</given-names></name>, <name><surname>He</surname><given-names>Y</given-names></name>, <name><surname>Karam</surname><given-names>AN</given-names></name>, <name><surname>Kawakami</surname><given-names>N</given-names></name>, &#x02026; <name><surname>Koenen</surname><given-names>KC</given-names></name> (<year>2014</year>). <article-title>Cumulative traumas and risk thresholds: 12-month PTSD in the World Mental Health (WMH) surveys</article-title>. <source>Depression and Anxiety</source>, <volume>31</volume>(<issue>2</issue>), <fpage>130</fpage>&#x02013;<lpage>142</lpage>. <pub-id pub-id-type="doi">10.1002/da.22169</pub-id> [doi]<pub-id pub-id-type="pmid">23983056</pub-id></mixed-citation></ref><ref id="R24"><mixed-citation publication-type="journal"><name><surname>Kelley</surname><given-names>LP</given-names></name>, <name><surname>Weathers</surname><given-names>FW</given-names></name>, <name><surname>McDevitt-Murphy</surname><given-names>ME</given-names></name>, <name><surname>Eakin</surname><given-names>DE</given-names></name>, &#x00026; <name><surname>Flood</surname><given-names>AM</given-names></name> (<year>2009</year>). <article-title>A comparison of PTSD symptom patterns in three types of civilian trauma: PTSD Symptom Patterns</article-title>. <source>Journal of Traumatic Stress</source>, <volume>22</volume>(<issue>3</issue>), <fpage>227</fpage>&#x02013;<lpage>235</lpage>. <pub-id pub-id-type="doi">10.1002/jts.20406</pub-id><pub-id pub-id-type="pmid">19444884</pub-id></mixed-citation></ref><ref id="R25"><mixed-citation publication-type="journal"><name><surname>Keshet</surname><given-names>H</given-names></name>, <name><surname>Foa</surname><given-names>EB</given-names></name>, &#x00026; <name><surname>Gilboa-Schechtman</surname><given-names>E</given-names></name> (<year>2019</year>). <article-title>Women&#x02019;s self-perceptions in the aftermath of trauma: The role of trauma-centrality and trauma-type</article-title>. <source>Psychological Trauma: Theory, Research, Practice, and Policy</source>, <volume>11</volume>(<issue>5</issue>), <fpage>542</fpage>&#x02013;<lpage>550</lpage>. <pub-id pub-id-type="doi">10.1037/tra0000393</pub-id></mixed-citation></ref><ref id="R26"><mixed-citation publication-type="journal"><name><surname>Kessler</surname><given-names>RC</given-names></name>, <name><surname>Aguilar-Gaxiola</surname><given-names>S</given-names></name>, <name><surname>Alonso</surname><given-names>J</given-names></name>, <name><surname>Bromet</surname><given-names>EJ</given-names></name>, <name><surname>Gureje</surname><given-names>O</given-names></name>, <name><surname>Karam</surname><given-names>EG</given-names></name>, <name><surname>Koenen</surname><given-names>KC</given-names></name>, <name><surname>Lee</surname><given-names>S</given-names></name>, <name><surname>Liu</surname><given-names>H</given-names></name>, <name><surname>Pennell</surname><given-names>B-E</given-names></name>, <name><surname>Petukhova</surname><given-names>MV</given-names></name>, <name><surname>Sampson</surname><given-names>NA</given-names></name>, <name><surname>Shahly</surname><given-names>V</given-names></name>, <name><surname>Stein</surname><given-names>DJ</given-names></name>, <name><surname>Atwoli</surname><given-names>L</given-names></name>, <name><surname>Borges</surname><given-names>G</given-names></name>, <name><surname>Bunting</surname><given-names>B</given-names></name>, <name><surname>de Girolamo</surname><given-names>G</given-names></name>, <name><surname>Gluzman</surname><given-names>SF</given-names></name>, &#x02026; <name><surname>Zaslavsky</surname><given-names>AM</given-names></name> (<year>2018</year>). <article-title>The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas</article-title>. <source>Molecular Psychiatry</source>, <volume>23</volume>(<issue>9</issue>), <fpage>1892</fpage>&#x02013;<lpage>1899</lpage>. <pub-id pub-id-type="doi">10.1038/mp.2017.194</pub-id><pub-id pub-id-type="pmid">28924183</pub-id></mixed-citation></ref><ref id="R27"><mixed-citation publication-type="journal"><name><surname>Kessler</surname><given-names>RC</given-names></name>, <name><surname>Aguilar-Gaxiola</surname><given-names>S</given-names></name>, <name><surname>Alonso</surname><given-names>J</given-names></name>, <name><surname>Benjet</surname><given-names>C</given-names></name>, <name><surname>Bromet</surname><given-names>EJ</given-names></name>, <name><surname>Cardoso</surname><given-names>G</given-names></name>, <name><surname>Degenhardt</surname><given-names>L</given-names></name>, <name><surname>de Girolamo</surname><given-names>G</given-names></name>, <name><surname>Dinolova</surname><given-names>RV</given-names></name>, <name><surname>Ferry</surname><given-names>F</given-names></name>, <name><surname>Florescu</surname><given-names>S</given-names></name>, <name><surname>Gureje</surname><given-names>O</given-names></name>, <name><surname>Haro</surname><given-names>JM</given-names></name>, <name><surname>Huang</surname><given-names>Y</given-names></name>, <name><surname>Karam</surname><given-names>EG</given-names></name>, <name><surname>Kawakami</surname><given-names>N</given-names></name>, <name><surname>Lee</surname><given-names>S</given-names></name>, <name><surname>Lepine</surname><given-names>J-P</given-names></name>, <name><surname>Levinson</surname><given-names>D</given-names></name>, &#x02026; <name><surname>Koenen</surname><given-names>KC</given-names></name> (<year>2017</year>). <article-title>Trauma and PTSD in the WHO World Mental Health Surveys</article-title>. <source>European Journal of Psychotraumatology</source>, <volume>8</volume>(<issue>sup5</issue>), <fpage>1353383</fpage>. <pub-id pub-id-type="doi">10.1080/20008198.2017.1353383</pub-id><pub-id pub-id-type="pmid">29075426</pub-id></mixed-citation></ref><ref id="R28"><mixed-citation publication-type="journal"><name><surname>Kilpatrick</surname><given-names>DG</given-names></name>, <name><surname>Resnick</surname><given-names>HS</given-names></name>, <name><surname>Milanak</surname><given-names>ME</given-names></name>, <name><surname>Miller</surname><given-names>MW</given-names></name>, <name><surname>Keyes</surname><given-names>KM</given-names></name>, &#x00026; <name><surname>Friedman</surname><given-names>MJ</given-names></name> (<year>2013</year>). <article-title>National estimates of exposure to traumatic events and PTSD prevalence using DSM-IV and DSM-5 criteria</article-title>. <source>Journal of Traumatic Stress</source>, <volume>26</volume>(<issue>5</issue>), <fpage>537</fpage>&#x02013;<lpage>547</lpage>. <pub-id pub-id-type="doi">10.1002/jts.21848</pub-id> [doi]<pub-id pub-id-type="pmid">24151000</pub-id></mixed-citation></ref><ref id="R29"><mixed-citation publication-type="journal"><name><surname>Kubany</surname><given-names>ES</given-names></name>, <name><surname>Haynes</surname><given-names>SN</given-names></name>, <name><surname>Leisen</surname><given-names>MB</given-names></name>, <name><surname>Owens</surname><given-names>JA</given-names></name>, <name><surname>Kaplan</surname><given-names>AS</given-names></name>, <name><surname>Watson</surname><given-names>SB</given-names></name>, &#x00026; <name><surname>Burns</surname><given-names>K</given-names></name> (<year>2000</year>). <article-title>Development and preliminary validation of a brief broad-spectrum measure of trauma exposure: The Traumatic Life Events Questionnaire</article-title>. <source>Psychological Assessment</source>, <volume>12</volume>(<issue>2</issue>), <fpage>210</fpage>&#x02013;<lpage>224</lpage>. <pub-id pub-id-type="doi">10.1037//1040-3590.12.2.210</pub-id><pub-id pub-id-type="pmid">10887767</pub-id></mixed-citation></ref><ref id="R30"><mixed-citation publication-type="journal"><name><surname>Lee</surname><given-names>SY</given-names></name>, &#x00026; <name><surname>Park</surname><given-names>CL</given-names></name> (<year>2018</year>). <article-title>Trauma exposure, posttraumatic stress, and preventive health behaviours: A systematic review</article-title>. <source>Health Psychology Review</source>, <volume>12</volume>(<issue>1</issue>), <fpage>75</fpage>&#x02013;<lpage>109</lpage>. <pub-id pub-id-type="doi">10.1080/17437199.2017.1373030</pub-id><pub-id pub-id-type="pmid">28854859</pub-id></mixed-citation></ref><ref id="R31"><mixed-citation publication-type="journal"><name><surname>Letica-Crepulja</surname><given-names>M</given-names></name>, <name><surname>Stevanovi&#x00107;</surname><given-names>A</given-names></name>, <name><surname>Protu&#x00111;er</surname><given-names>M</given-names></name>, <name><surname>Grahovac Jureti&#x00107;</surname><given-names>T</given-names></name>, <name><surname>Rebi&#x00107;</surname><given-names>J</given-names></name>, &#x00026; <name><surname>Fran&#x0010d;i&#x00161;kovi&#x00107;</surname><given-names>T</given-names></name> (<year>2020</year>). <article-title>Complex PTSD among treatment-seeking veterans with PTSD</article-title>. <source>European Journal of Psychotraumatology</source>, <volume>11</volume>(<issue>1</issue>), <fpage>1716593</fpage>. <pub-id pub-id-type="doi">10.1080/20008198.2020.1716593</pub-id><pub-id pub-id-type="pmid">32166005</pub-id></mixed-citation></ref><ref id="R32"><mixed-citation publication-type="journal"><name><surname>Milligan-Saville</surname><given-names>J</given-names></name>, <name><surname>Choi</surname><given-names>I</given-names></name>, <name><surname>Deady</surname><given-names>M</given-names></name>, <name><surname>Scott</surname><given-names>P</given-names></name>, <name><surname>Tan</surname><given-names>L</given-names></name>, <name><surname>Calvo</surname><given-names>RA</given-names></name>, <name><surname>Bryant</surname><given-names>RA</given-names></name>, <name><surname>Glozier</surname><given-names>N</given-names></name>, &#x00026; <name><surname>Harvey</surname><given-names>SB</given-names></name> (<year>2018</year>). <article-title>The impact of trauma exposure on the development of PTSD and psychological distress in a volunteer fire service</article-title>. <source>Psychiatry Research</source>, <volume>270</volume>, <fpage>1110</fpage>&#x02013;<lpage>1115</lpage>. <pub-id pub-id-type="doi">10.1016/j.psychres.2018.06.058</pub-id><pub-id pub-id-type="pmid">30190167</pub-id></mixed-citation></ref><ref id="R33"><mixed-citation publication-type="journal"><name><surname>M&#x000f8;ller</surname><given-names>L</given-names></name>, <name><surname>Augsburger</surname><given-names>M</given-names></name>, <name><surname>Elklit</surname><given-names>A</given-names></name>, <name><surname>S&#x000f8;gaard</surname><given-names>U</given-names></name>, &#x00026; <name><surname>Simonsen</surname><given-names>E</given-names></name> (<year>2020</year>). <article-title>Traumatic experiences, ICD-11 PTSD, ICD-11 complex PTSD, and the overlap with ICD-10 diagnoses</article-title>. <source>Acta Psychiatrica Scandinavica</source>, <volume>141</volume>(<issue>5</issue>), <fpage>421</fpage>&#x02013;<lpage>431</lpage>. <pub-id pub-id-type="doi">10.1111/acps.13161</pub-id><pub-id pub-id-type="pmid">32049369</pub-id></mixed-citation></ref><ref id="R34"><mixed-citation publication-type="journal"><name><surname>Ozer</surname><given-names>EJ</given-names></name>, <name><surname>Best</surname><given-names>SR</given-names></name>, <name><surname>Lipsey</surname><given-names>TL</given-names></name>, &#x00026; <name><surname>Weiss</surname><given-names>DS</given-names></name> (<year>2003</year>). <article-title>Predictors of posttraumatic stress disorder and symptoms in adults: A meta-analysis</article-title>. <source>Psychological Bulletin</source>, <volume>129</volume>(<issue>1</issue>), <fpage>52</fpage>&#x02013;<lpage>73</lpage>. <pub-id pub-id-type="doi">10.1037/0033-2909.129.1.52</pub-id><pub-id pub-id-type="pmid">12555794</pub-id></mixed-citation></ref><ref id="R35"><mixed-citation publication-type="journal"><name><surname>Pugach</surname><given-names>CP</given-names></name>, <name><surname>Nomamiukor</surname><given-names>FO</given-names></name>, <name><surname>Gay</surname><given-names>NG</given-names></name>, &#x00026; <name><surname>Wisco</surname><given-names>BE</given-names></name> (<year>2020</year>). <article-title>Temporal Stability of Self-Reported Trauma Exposure on the Life Events Checklist for <italic toggle="yes">DSM-5</italic></article-title>. <source>Journal of Traumatic Stress</source>, <fpage>jts.22611</fpage>. <pub-id pub-id-type="doi">10.1002/jts.22611</pub-id></mixed-citation></ref><ref id="R36"><mixed-citation publication-type="journal"><name><surname>Qi</surname><given-names>W</given-names></name>, <name><surname>Gevonden</surname><given-names>M</given-names></name>, &#x00026; <name><surname>Shalev</surname><given-names>A</given-names></name> (<year>2016</year>). <article-title>Prevention of Post-Traumatic Stress Disorder After Trauma: Current Evidence and Future Directions</article-title>. <source>Current Psychiatry Reports</source>, <volume>18</volume>(<issue>2</issue>), <fpage>20</fpage>. <pub-id pub-id-type="doi">10.1007/s11920-015-0655-0</pub-id><pub-id pub-id-type="pmid">26800995</pub-id></mixed-citation></ref><ref id="R37"><mixed-citation publication-type="journal"><name><surname>Reger</surname><given-names>GM</given-names></name>, <name><surname>Bourassa</surname><given-names>KJ</given-names></name>, <name><surname>Smolenski</surname><given-names>D</given-names></name>, <name><surname>Buck</surname><given-names>B</given-names></name>, &#x00026; <name><surname>Norr</surname><given-names>AM</given-names></name> (<year>2019</year>). <article-title>Lifetime trauma exposure among those with combat-related PTSD: Psychiatric risk among U.S. military personnel</article-title>. <source>Psychiatry Research</source>, <volume>278</volume>, <fpage>309</fpage>&#x02013;<lpage>314</lpage>. <pub-id pub-id-type="doi">10.1016/j.psychres.2019.06.033</pub-id><pub-id pub-id-type="pmid">31255954</pub-id></mixed-citation></ref><ref id="R38"><mixed-citation publication-type="journal"><name><surname>Rizopoulos</surname><given-names>D</given-names></name> (<year>2006</year>). <article-title><bold>ltm</bold>: An <italic toggle="yes">R</italic> Package for Latent Variable Modeling and Item Response Theory Analyses</article-title>. <source>Journal of Statistical Software</source>, <volume>17</volume>(<issue>5</issue>). <pub-id pub-id-type="doi">10.18637/jss.v017.i05</pub-id></mixed-citation></ref><ref id="R39"><mixed-citation publication-type="journal"><name><surname>Roberts</surname><given-names>AL</given-names></name>, <name><surname>Gilman</surname><given-names>SE</given-names></name>, <name><surname>Breslau</surname><given-names>J</given-names></name>, <name><surname>Breslau</surname><given-names>N</given-names></name>, &#x00026; <name><surname>Koenen</surname><given-names>KC</given-names></name> (<year>2011</year>). <article-title>Race/ethnic differences in exposure to traumatic events, development of post-traumatic stress disorder, and treatment-seeking for post-traumatic stress disorder in the United States</article-title>. <source>Psychological Medicine</source>, <volume>41</volume>(<issue>1</issue>), <fpage>71</fpage>&#x02013;<lpage>83</lpage>. <pub-id pub-id-type="doi">10.1017/S0033291710000401</pub-id><pub-id pub-id-type="pmid">20346193</pub-id></mixed-citation></ref><ref id="R40"><mixed-citation publication-type="journal"><name><surname>Sacchi</surname><given-names>L</given-names></name>, <name><surname>Merzhvynska</surname><given-names>M</given-names></name>, &#x00026; <name><surname>Augsburger</surname><given-names>M</given-names></name> (<year>2020</year>). <article-title>Effects of cumulative trauma load on long-term trajectories of life satisfaction and health in a population-based study</article-title>. <source>BMC Public Health</source>, <volume>20</volume>(<issue>1</issue>), <fpage>1612</fpage>. <pub-id pub-id-type="doi">10.1186/s12889-020-09663-9</pub-id><pub-id pub-id-type="pmid">33109171</pub-id></mixed-citation></ref><ref id="R41"><mixed-citation publication-type="journal"><name><surname>Sareen</surname><given-names>J</given-names></name> (<year>2014</year>). <article-title>Posttraumatic Stress Disorder in Adults: Impact, Comorbidity, Risk Factors, and Treatment</article-title>. <source>The Canadian Journal of Psychiatry</source>, <volume>59</volume>(<issue>9</issue>), <fpage>460</fpage>&#x02013;<lpage>467</lpage>. <pub-id pub-id-type="doi">10.1177/070674371405900902</pub-id><pub-id pub-id-type="pmid">25565692</pub-id></mixed-citation></ref><ref id="R42"><mixed-citation publication-type="journal"><name><surname>Shalev</surname><given-names>AY</given-names></name>, <name><surname>Gevonden</surname><given-names>M</given-names></name>, <name><surname>Ratanatharathorn</surname><given-names>A</given-names></name>, <name><surname>Laska</surname><given-names>E</given-names></name>, <name><surname>van der Mei</surname><given-names>WF</given-names></name>, <name><surname>Qi</surname><given-names>W</given-names></name>, <name><surname>Lowe</surname><given-names>S</given-names></name>, <name><surname>Lai</surname><given-names>BS</given-names></name>, <name><surname>Bryant</surname><given-names>RA</given-names></name>, <name><surname>Delahanty</surname><given-names>D</given-names></name>, <name><surname>Matsuoka</surname><given-names>YJ</given-names></name>, <name><surname>Olff</surname><given-names>M</given-names></name>, <name><surname>Schnyder</surname><given-names>U</given-names></name>, <name><surname>Seedat</surname><given-names>S</given-names></name>, <name><surname>deRoon-Cassini</surname><given-names>TA</given-names></name>, <name><surname>Kessler</surname><given-names>RC</given-names></name>, &#x00026; <name><surname>Koenen</surname><given-names>KC</given-names></name> (<year>2019</year>). <article-title>Estimating the risk of PTSD in recent trauma survivors: Results of the International Consortium to Predict PTSD (ICPP)</article-title>. <source>World Psychiatry</source>, <volume>18</volume>(<issue>1</issue>), <fpage>77</fpage>&#x02013;<lpage>87</lpage>. <pub-id pub-id-type="doi">10.1002/wps.20608</pub-id><pub-id pub-id-type="pmid">30600620</pub-id></mixed-citation></ref><ref id="R43"><mixed-citation publication-type="journal"><name><surname>Thompson</surname><given-names>NJ</given-names></name>, <name><surname>Fiorillo</surname><given-names>D</given-names></name>, <name><surname>Rothbaum</surname><given-names>BO</given-names></name>, <name><surname>Ressler</surname><given-names>KJ</given-names></name>, &#x00026; <name><surname>Michopoulos</surname><given-names>V</given-names></name> (<year>2018</year>). <article-title>Coping strategies as mediators in relation to resilience and posttraumatic stress disorder</article-title>. <source>Journal of Affective Disorders</source>, <volume>225</volume>, <fpage>153</fpage>&#x02013;<lpage>159</lpage>. <comment>https://doi.org/S0165-0327(16)32417-X</comment> [pii]<pub-id pub-id-type="pmid">28837948</pub-id></mixed-citation></ref><ref id="R44"><mixed-citation publication-type="journal"><name><surname>Ungar</surname><given-names>M</given-names></name> (<year>2013</year>). <article-title>Resilience, Trauma, Context, and Culture</article-title>. <source>Trauma, Violence, &#x00026; Abuse</source>, <volume>14</volume>(<issue>3</issue>), <fpage>255</fpage>&#x02013;<lpage>266</lpage>. <pub-id pub-id-type="doi">10.1177/1524838013487805</pub-id></mixed-citation></ref><ref id="R45"><mixed-citation publication-type="book"><collab>U.S. Department of Veterans Affairs</collab>. (<year>2019</year>). <source>How Common is PTSD in Adults?</source>
<publisher-name>PTSD: National Center for PTSD</publisher-name>. <comment><ext-link xlink:href="https://www.ptsd.va.gov/understand/common/common_adults.asp" ext-link-type="uri">https://www.ptsd.va.gov/understand/common/common_adults.asp</ext-link></comment></mixed-citation></ref><ref id="R46"><mixed-citation publication-type="journal"><name><surname>Weathers</surname><given-names>FW</given-names></name>, <name><surname>Blake</surname><given-names>DD</given-names></name>, <name><surname>Schnurr</surname><given-names>PP</given-names></name>, <name><surname>Kaloupeck</surname><given-names>DG</given-names></name>, <name><surname>Marx</surname><given-names>BP</given-names></name>, &#x00026; <name><surname>Keane</surname><given-names>TM</given-names></name> (<year>2013</year>). <source>The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5)</source>.</mixed-citation></ref><ref id="R47"><mixed-citation publication-type="journal"><name><surname>Weis</surname><given-names>CN</given-names></name>, <name><surname>Belleau</surname><given-names>EL</given-names></name>, <name><surname>Pedersen</surname><given-names>WS</given-names></name>, <name><surname>Miskovich</surname><given-names>TA</given-names></name>, &#x00026; <name><surname>Larson</surname><given-names>CL</given-names></name> (<year>2018</year>). <article-title>Structural Connectivity of the Posterior Cingulum Is Related to Reexperiencing Symptoms in Posttraumatic Stress Disorder</article-title>. <source>Chronic Stress</source>, <volume>2</volume>. <pub-id pub-id-type="doi">10.1177/2470547018807134</pub-id></mixed-citation></ref><ref id="R48"><mixed-citation publication-type="journal"><name><surname>White</surname><given-names>J</given-names></name>, <name><surname>Pearce</surname><given-names>J</given-names></name>, <name><surname>Morrison</surname><given-names>S</given-names></name>, <name><surname>Dunstan</surname><given-names>F</given-names></name>, <name><surname>Bisson</surname><given-names>JI</given-names></name>, &#x00026; <name><surname>Fone</surname><given-names>DL</given-names></name> (<year>2015</year>). <article-title>Risk of post-traumatic stress disorder following traumatic events in a community sample</article-title>. <source>Epidemiology and Psychiatric Sciences</source>, <volume>24</volume>(<issue>3</issue>), <fpage>249</fpage>&#x02013;<lpage>257</lpage>. <pub-id pub-id-type="doi">10.1017/S2045796014000110</pub-id><pub-id pub-id-type="pmid">24636704</pub-id></mixed-citation></ref><ref id="R49"><mixed-citation publication-type="journal"><name><surname>Wisco</surname><given-names>BE</given-names></name>, <name><surname>Marx</surname><given-names>BP</given-names></name>, <name><surname>Wolf</surname><given-names>EJ</given-names></name>, <name><surname>Miller</surname><given-names>MW</given-names></name>, <name><surname>Southwick</surname><given-names>SM</given-names></name>, &#x00026; <name><surname>Pietrzak</surname><given-names>RH</given-names></name> (<year>2014</year>). <article-title>Posttraumatic Stress Disorder in the US Veteran Population: Results From the National Health and Resilience in Veterans Study</article-title>. <source>The Journal of Clinical Psychiatry</source>, <volume>75</volume>(<issue>12</issue>), <fpage>1338</fpage>&#x02013;<lpage>1346</lpage>. <pub-id pub-id-type="doi">10.4088/JCP.14m09328</pub-id><pub-id pub-id-type="pmid">25551234</pub-id></mixed-citation></ref><ref id="R50"><mixed-citation publication-type="journal"><name><surname>Wu</surname><given-names>G</given-names></name>, <name><surname>Feder</surname><given-names>A</given-names></name>, <name><surname>Cohen</surname><given-names>H</given-names></name>, <name><surname>Kim</surname><given-names>JJ</given-names></name>, <name><surname>Calderon</surname><given-names>S</given-names></name>, <name><surname>Charney</surname><given-names>DS</given-names></name>, &#x00026; <name><surname>Mathe</surname><given-names>AA</given-names></name> (<year>2013</year>). <article-title>Understanding Resilience</article-title>. <source>Frontiers in Behavioral Neuroscience</source>, <volume>7</volume>.</mixed-citation></ref></ref-list></back><floats-group><table-wrap position="float" id="T1"><label>Table 1.</label><caption><p id="P36">Sample Characteristics</p></caption><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th align="center" valign="top" rowspan="1" colspan="1"/><th align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">iSTAR (n=215)</th><th align="center" valign="top" rowspan="1" colspan="1">STAR 1.0 (n=278)</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">
<bold>Gender (M/F)</bold>
</td><td align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">103/112</td><td align="center" valign="top" rowspan="1" colspan="1">201/77</td></tr><tr><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">
<bold>Age (mean/SD)</bold>
</td><td align="center" valign="top" style="border-bottom: solid 1px; border-right: solid 1px" rowspan="1" colspan="1">32.89/10.68</td><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">39.86/15.64</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">
<bold>Race (count/percent of sample)</bold>
</td><td align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="top" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">American Indian or Alaska Native</td><td align="center" valign="top" style="border-bottom: solid 1px; border-right: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">2 (&#x0003c;1%)</td></tr><tr><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">Asian</td><td align="center" valign="top" style="border-bottom: solid 1px; border-right: solid 1px" rowspan="1" colspan="1">4 (1%)</td><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">Black or African American</td><td align="center" valign="top" style="border-bottom: solid 1px; border-right: solid 1px" rowspan="1" colspan="1">124 (57%)</td><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">124 (44%)</td></tr><tr><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">Hispanic or Latino</td><td align="center" valign="top" style="border-bottom: solid 1px; border-right: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">24 (8%)</td></tr><tr><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">White</td><td align="center" valign="top" style="border-bottom: solid 1px; border-right: solid 1px" rowspan="1" colspan="1">58 (27%)</td><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">128 (46%)</td></tr><tr><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">More than one</td><td align="center" valign="top" style="border-bottom: solid 1px; border-right: solid 1px" rowspan="1" colspan="1">15 (7%)</td><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">Unknown or Not Reported</td><td align="center" valign="top" style="border-bottom: solid 1px; border-right: solid 1px" rowspan="1" colspan="1">13 (6%)</td><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">
<bold>LEC (Baseline)</bold>
</td><td align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="top" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">Exp</td><td align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">4.96</td><td align="center" valign="top" rowspan="1" colspan="1">5.22</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">Total</td><td align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">16.52</td><td align="center" valign="top" rowspan="1" colspan="1">17.23</td></tr><tr><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">Weighted</td><td align="center" valign="top" style="border-bottom: solid 1px; border-right: solid 1px" rowspan="1" colspan="1">30.99</td><td align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">32.47</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">
<bold>CAPS-5 (6-months)</bold>
</td><td align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">(n=191)</td><td align="center" valign="top" rowspan="1" colspan="1">(n=172)</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">Total Severity (mean/SD)</td><td align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">13.69/12.05</td><td align="center" valign="top" rowspan="1" colspan="1">13.54/15.20</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">Dx (+/&#x02212;)</td><td align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">42/191</td><td align="center" valign="top" rowspan="1" colspan="1">50/172</td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><p id="P37"><italic toggle="yes">Note:</italic>
<bold>M,</bold> male; <bold>F,</bold> female; <bold>Exp,</bold> experienced events only score; <bold>Total</bold>, standard total score, <bold>Weighted,</bold> weighted score<bold>; LEC,</bold> life events checklist; <bold>CAPS-5,</bold> Clinician Administered PTSD Scale for DSM-5; <bold>SD,</bold> standard deviation; <bold>Dx,</bold> PTSD diagnostic status.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="T2"><label>Table 2.</label><caption><p id="P38">R<sup>2</sup> Values Between Life Events Checklist Scores in iSTAR and STAR 1.0</p></caption><table frame="hsides" rules="none"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th colspan="4" align="center" valign="top" style="border-bottom: solid 1px; border-right: solid 1px" rowspan="1">iSTAR (N = 215)<break/>Baseline (2-week)</th><th colspan="4" align="center" valign="top" style="border-bottom: solid 1px" rowspan="1">STAR 1.0 (N = 278)<break/>Baseline (In-hospital)</th></tr><tr><th align="left" valign="top" rowspan="1" colspan="1"/><th align="left" valign="top" rowspan="1" colspan="1">Exp</th><th align="left" valign="top" rowspan="1" colspan="1">Total</th><th align="left" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">Weighted</th><th align="left" valign="top" rowspan="1" colspan="1"/><th align="left" valign="top" rowspan="1" colspan="1">Exp</th><th align="left" valign="top" rowspan="1" colspan="1">Total</th><th align="left" valign="top" rowspan="1" colspan="1">Weighted</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Exp</td><td align="left" valign="top" rowspan="1" colspan="1">
<bold>--</bold>
</td><td align="left" valign="top" rowspan="1" colspan="1">
<bold>0.69</bold>
<xref rid="TFN3" ref-type="table-fn">***</xref>
</td><td align="left" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">
<bold>0.81</bold>
<xref rid="TFN3" ref-type="table-fn">***</xref>
</td><td align="left" valign="top" rowspan="1" colspan="1">Exp</td><td align="left" valign="top" rowspan="1" colspan="1">
<bold>--</bold>
</td><td align="left" valign="top" rowspan="1" colspan="1">
<bold>0.57</bold>
<xref rid="TFN3" ref-type="table-fn">***</xref>
</td><td align="left" valign="top" rowspan="1" colspan="1">
<bold>0.75</bold>
<xref rid="TFN3" ref-type="table-fn">***</xref>
</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Total</td><td align="left" valign="top" rowspan="1" colspan="1"/><td align="left" valign="top" rowspan="1" colspan="1">
<bold>--</bold>
</td><td align="left" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">
<bold>0.97</bold>
<xref rid="TFN3" ref-type="table-fn">***</xref>
</td><td align="left" valign="top" rowspan="1" colspan="1">Total</td><td align="left" valign="top" rowspan="1" colspan="1"/><td align="left" valign="top" rowspan="1" colspan="1">
<bold>--</bold>
</td><td align="left" valign="top" rowspan="1" colspan="1">
<bold>0.95</bold>
<xref rid="TFN3" ref-type="table-fn">***</xref>
</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Weighted</td><td align="left" valign="top" rowspan="1" colspan="1"/><td align="left" valign="top" rowspan="1" colspan="1"/><td align="left" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">
<bold>--</bold>
</td><td align="left" valign="top" rowspan="1" colspan="1">Weighted</td><td align="left" valign="top" rowspan="1" colspan="1"/><td align="left" valign="top" rowspan="1" colspan="1"/><td align="left" valign="top" rowspan="1" colspan="1">
<bold>--</bold>
</td></tr></tbody></table><table-wrap-foot><fn id="TFN2"><p id="P39"><italic toggle="yes">Note:</italic>
<bold>Exp,</bold> experienced events only score; <bold>Total</bold>, standard total score, <bold>Weighted,</bold> weighted score</p></fn><fn id="TFN3"><label>***</label><p id="P40">
<bold><italic toggle="yes">p</italic> &#x0003c; 0.001.</bold>
</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="T3"><label>Table 3.</label><caption><p id="P41">Reliability of LEC Measures Across Samples (Cronbach&#x02019;s &#x003b1;)</p></caption><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><th align="center" valign="top" style="border-bottom: solid 1px; border-right: solid 1px" rowspan="1" colspan="1">iSTAR</th><th align="center" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">STAR 1.0</th></tr><tr><th align="center" valign="top" rowspan="1" colspan="1"/><th align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">&#x003b1; (95% CI)</th><th align="center" valign="top" rowspan="1" colspan="1">&#x003b1; (95% CI)</th></tr></thead><tbody><tr><td align="center" valign="top" rowspan="1" colspan="1">Exp</td><td align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">0.67 (0.60, 0.73)</td><td align="center" valign="top" rowspan="1" colspan="1">0.59 (0.51, 0.65)</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">Total</td><td align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">0.91 (0.89, 0.92)</td><td align="center" valign="top" rowspan="1" colspan="1">0.87 (0.84, 0.89)</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">Weighted</td><td align="center" valign="top" style="border-right: solid 1px" rowspan="1" colspan="1">0.87 (0.85, 0.89)</td><td align="center" valign="top" rowspan="1" colspan="1">0.83 (0.80, 0.86)</td></tr></tbody></table><table-wrap-foot><fn id="TFN4"><p id="P42"><italic toggle="yes">Note:</italic>
<bold>CI,</bold> confidence interval; <bold>Exp,</bold> experienced events only score; <bold>Total</bold>, standard total score, <bold>Weighted,</bold> weighted score.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="T4"><label>Table 4.</label><caption><p id="P43">R<sup>2</sup> Values of LEC Correlations with CAPS</p></caption><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th align="left" valign="middle" rowspan="1" colspan="1"/><th align="left" valign="middle" rowspan="1" colspan="1"/><th colspan="3" align="center" valign="middle" rowspan="1">Baseline LEC</th></tr><tr><th align="left" valign="middle" rowspan="1" colspan="1"/><th align="left" valign="middle" rowspan="1" colspan="1"/><th align="center" valign="middle" style="border-right: solid 1px" rowspan="1" colspan="1">Exp</th><th align="center" valign="middle" style="border-right: solid 1px" rowspan="1" colspan="1">Total</th><th align="center" valign="middle" rowspan="1" colspan="1">Weighted</th></tr></thead><tbody><tr><td rowspan="2" align="left" valign="middle" style="border-right: solid 1px" colspan="1">CAPS (6-months)</td><td align="left" valign="middle" style="border-right: solid 1px; border-bottom: solid 1px" rowspan="1" colspan="1">iSTAR (n=191)</td><td align="center" valign="middle" style="border-right: solid 1px; border-bottom: solid 1px" rowspan="1" colspan="1">
<bold>0.031</bold>
<xref rid="TFN6" ref-type="table-fn">*</xref>
</td><td align="center" valign="middle" style="border-right: solid 1px; border-bottom: solid 1px" rowspan="1" colspan="1">
<bold>0.034</bold>
<xref rid="TFN7" ref-type="table-fn">**</xref>
</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">
<bold>0.031</bold>
<xref rid="TFN6" ref-type="table-fn">*</xref>
</td></tr><tr><td align="left" valign="middle" style="border-right: solid 1px" rowspan="1" colspan="1">STAR (n=172)</td><td align="center" valign="middle" style="border-right: solid 1px" rowspan="1" colspan="1">
<bold>0.03</bold>
<xref rid="TFN6" ref-type="table-fn">*</xref>
</td><td align="center" valign="middle" style="border-right: solid 1px" rowspan="1" colspan="1">0.01</td><td align="center" valign="middle" rowspan="1" colspan="1">0.02</td></tr></tbody></table><table-wrap-foot><fn id="TFN5"><p id="P44"><italic toggle="yes">Note:</italic>
<bold>Exp,</bold> experienced events only score; <bold>Total</bold>, standard total score, <bold>Weighted,</bold> weighted score;</p></fn><fn id="TFN6"><label>*</label><p id="P45">
<bold><italic toggle="yes">p</italic> &#x0003c; 0.05,</bold>
</p></fn><fn id="TFN7"><label>**</label><p id="P46">
<bold><italic toggle="yes">p</italic> &#x0003c; 0.01.</bold>
</p></fn></table-wrap-foot></table-wrap><boxed-text id="BX1" position="float"><caption><title>Clinical Impact Statement:</title></caption><p id="P47">The Life Events Checklist (LEC) is a widely used self-report measure of trauma history that categorizes events by the proximity of trauma exposure; however, the field has published multiple scoring methods for the LEC. We proposed a novel scoring procedure in which total scores are weighted according to the proximity of trauma exposure with &#x0201c;experienced&#x0201d; events weighted most and &#x0201c;learned about&#x0201d; events weighted least. Results assessed in two traumatically injured civilian samples indicated the weighted score is reliable and valid. Future utilization of this scoring method will provide a comprehensive estimate of lifetime trauma while emphasizing proximity of trauma exposure.</p></boxed-text></floats-group></article>