Emerg Infect DisEIDEmerging Infectious Diseases1080-60401080-6059Centers for Disease Control and Prevention17479914272586606-110510.3201/eid1302.061105Letters to the EditorMaculopathy and DengueMaculopathy and DengueLaudeAugustinus*ChlebickiMaciej Piotr*AngBrenda*BarkhamTimothy*Tan Tock Seng Hospital, SingaporeAddress for correspondence: Augustinus Laude, Tan Tock Seng Hospital, 11, Jalan Tan Tock Seng, Singapore 308433, Singapore; email: laude_augustinus@ttsh.com.sg22007132347348SuDH , CheeSP . Maculopathy in dengue fever.Emerg Infect Dis. 2006;12:707.16715586Keywords: Retinal hemorrhagedengueophthalmic complicationsletter

To the Editor: We thank Su and Chee (1) for their interest in our article, “Retinal Hemorrhages in 4 Patients with Dengue Fever” (2). We reported the findings of this small case series to highlight the presence of retinal hemorrhage as a manifestation of ophthalmic complication in patients with dengue fever. We wanted to describe characteristic clinical features (such as association of onset of visual symptoms with resolution of fever and nadir of thrombocytopenia) and propose epidemiologic explanations for the sudden rise in the incidence of observed ocular complications of dengue fever in our population. Our article did not attempt to conclude that the retinal hemorrhages were responsible for the patients’ visual symptoms, as suggested by Su et al. In fact, we stated that in all 4 patients “fundoscopic examination showed macular hemorrhages and exudative maculopathy.”

The range of dengue-related ophthalmic complication is still being investigated, and we agree with Su and Chee that other ophthalmic manifestations may occur in patients with dengue fever. In a retrospective observational case series involving 22 eyes of 13 patients with visual impairment from dengue infection, carried out in our hospital, Chan et al. (3) found evidence of retinal hemorrhage, macular edema, cotton wool spots, retinal vasculitis, exudative retinal detachment, and anterior uveitis. Therefore, physicians and ophthalmologists should be aware of the possibilities of ophthalmic complications in the management of patients with dengue fever.

Suggested citation for this article: Laude A, Chlebicki MP, Ang B, Barkham T. Maculopathy and dengue [reply]. Emerg Infect Dis [serial on the Internet]. 2007 Feb [date cited]. Available from http://www.cdc.gov/eid/content/13/2/347.htm

References:Su DH, Chee SP Maculopathy in dengue fever.Emerg Infect Dis 2006;12:70716715586Chlebicki MP, Ang B, Barkham T, Laude A Retinal hemorrhages in 4 patients with dengue fever.Emerg Infect Dis 2005;11:770215890137Chan DP, Teoh SC, Tan CS, Nah GK, Rajagopalan R, Prabhakaragupta MK, Ophthalmic complications of dengue.Emerg Infect Dis 2006;12:285916494756