Similar Biochemical Signatures and Prion Protein Genotypes in Atypical Scrapie and Nor98 Cases, France and Norway
-
Published Date:Jan 2007
-
Publisher's site:
-
Source:Emerg Infect Dis. 13(1):58-65.
-
Details:
-
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:Isolates of atypical scrapie recently identified in sheep and goats in France were compared with Nor98 isolates reported in Norway. Western blot methods for characterization of the protease-resistant prion protein showed that all these isolates shared a unique biochemical signature: 5 groups of bands, including a characteristic band of apparent low molecular weight (11 kDa). This pattern could originate from the presence of 3 different protease cleavage products, including the 11 kDa most likely cleaved at both N- and C-sides of the protein. Genetic data, which strongly suggested the higher susceptibility of AHQ and AF141RQ animals in French cases, resembled earlier data from Nor98 scrapie.
-
Subject:
-
-
Document Type:
-
-
Collection(s):
-
Main Document Checksum:
-
Supporting Files:
text/plain image/gif image/jpeg image/gif image/jpeg image/gif image/jpeg text/plain
No Related Documents.
You May Also Like: