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Similar Biochemical Signatures and Prion Protein Genotypes in Atypical Scrapie and Nor98 Cases, France and Norway

Published Date:

Jan 2007

Publisher's site:

http://dx.doi.org/10.3201/eid1301.060393 New Site Icon

Source:

Emerg Infect Dis. 13(1):58-65.

[PDF-311.07 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Arsac, Jean-Noël ; Andreoletti, Olivier ; Bilheude, Jean-Marc ; Lacroux, Caroline ; Benestad, Sylvie L. ; ... More ▼

Description:

Isolates of atypical scrapie recently identified in sheep and goats in France were compared with Nor98 isolates reported in Norway. Western blot methods for characterization of the protease-resistant prion protein showed that all these isolates shared a unique biochemical signature: 5 groups of bands, including a characteristic band of apparent low molecular weight (11 kDa). This pattern could originate from the presence of 3 different protease cleavage products, including the 11 kDa most likely cleaved at both N- and C-sides of the protein. Genetic data, which strongly suggested the higher susceptibility of AHQ and AF141RQ animals in French cases, resembled earlier data from Nor98 scrapie.

Subject:

[+]

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

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