Welcome to CDC stacks | Similar Biochemical Signatures and Prion Protein Genotypes in Atypical Scrapie and Nor98 Cases, France and Norway - 16305

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Similar Biochemical Signatures and Prion Protein Genotypes in Atypical Scrapie and Nor98 Cases, France and Norway

Published Date:

Jan 2007

Publisher's site:

http://dx.doi.org/10.3201/eid1301.060393 New Site Icon

Source:

Emerg Infect Dis. 13(1):58-65.

[PDF-311.07 KB]

Details:

Personal Authors:

Arsac, Jean-Noël ; Andreoletti, Olivier ; Bilheude, Jean-Marc ; Lacroux, Caroline ; Benestad, Sylvie L. ; ... More ▼

Keywords:

[+]

Description:

Isolates of atypical scrapie recently identified in sheep and goats in France were compared with Nor98 isolates reported in Norway. Western blot methods for characterization of the protease-resistant prion protein showed that all these isolates shared a unique biochemical signature: 5 groups of bands, including a characteristic band of apparent low molecular weight (11 kDa). This pattern could originate from the presence of 3 different protease cleavage products, including the 11 kDa most likely cleaved at both N- and C-sides of the protein. Genetic data, which strongly suggested the higher susceptibility of AHQ and AF141RQ animals in French cases, resembled earlier data from Nor98 scrapie.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

	license.txt	text/plain
	06-0393-F1.gif	image/gif
	06-0393-F1.jpg	image/jpeg
	06-0393-F2.gif	image/gif
	06-0393-F2.jpg	image/jpeg
	06-0393-F3.gif	image/gif
	06-0393-F3.jpg	image/jpeg
	06-0393.nxml	text/plain

No Related Documents.

You May Also Like:

Transgenic Mice Expressing Porcine Prion Protein Resistant to Classical Scrapie but Susceptible to Sheep Bovine Spongiform Encephalopathy and Atypical Scrapie

Personal Author:

Espinosa, Juan-Carlos; Herva, María-Eugenia; Andréoletti, Olivier; Padilla, Danielle; Lacroux, Caroline; Cassard, Hervé; Lantier, Isabelle; Castilla, Joaquin; Torres, Juan-María;

Published:

Aug 2009

Source:

Emerg Infect Dis. 15(8):1214-1221.

Description:

How susceptible pigs are to infection with sheep prions is unknown. We show, through transmission experiments in transgenic mice expressing porcine prion protein (PrP), that the susceptibility of this mouse model to bovine spongiform encephalopathy (...

File Type:

[PDF - 496.33 KB]
Rapid Typing of Transmissible Spongiform Encephalopathy Strains with Differential ELISA

Personal Author:

Simon, Stéphanie; Nugier, Jérôme; Morel, Nathalie; Boutal, Hervé; Créminon, Christophe; Benestad, Sylvie L.; Andréoletti, Olivier; Lantier, Frédéric; Bilheude, Jean-Marc; Feyssaguet, Muriel; Biacabe, Anne-Gaëlle; Baron, Thierry; Grassi, Jacques;

Published:

Apr 2008

Source:

Emerg Infect Dis. 14(4):608-616.

Description:

The bovine spongiform encephalopathy (BSE) agent has been transmitted to humans, leading to variant Creutzfeldt-Jakob disease. Sheep and goats can be experimentally infected by BSE and have been potentially exposed to natural BSE; however, whether BS...

File Type:

[PDF - 473.60 KB]
Molecular Typing of Protease-Resistant Prion Protein in Transmissible Spongiform Encephalopathies of Small Ruminants, France, 2002–2009

Personal Author:

Vulin, Johann; Biacabe, Anne-Gaëlle; Cazeau, Géraldine; Calavas, Didier; Baron, Thierry;

Published:

Jan 2011

Source:

Emerg Infect Dis. 17(1):55-63.

Description:

The agent that causes bovine spongiform encephalopathy (BSE) may be infecting small ruminants, which could have serious implications for human health. To distinguish BSE from scrapie and to examine the molecular characteristics of the protease-resist...

File Type:

[PDF - 325.95 KB]
Classic Scrapie in Sheep with the ARR/ARR Prion Genotype in Germany and France

Personal Author:

Groschup, Martin H.; Lacroux, Caroline; Buschmann, Anne; Lühken, Gesine; Mathey, Jacinthe; Eiden, Martin; Lugan, Séverine; Hoffmann, Christine; Espinosa, Juan Carlos; Baron, Thierry; Torres, Juan Maria; Erhardt, Georg; Andreoletti, Olivier;

Published:

Aug 2007

Source:

Emerg Infect Dis. 13(8):1201-1207.

Description:

In the past, natural scrapie and bovine spongiform encephalopathy (BSE) infections have essentially not been diagnosed in sheep homozygous for the A136R154R171 haplotype of the prion protein. This genotype was therefore assumed to confer resistance t...

File Type:

[PDF - 310.69 KB]
Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway

Personal Author:

Pirisinu, Laura; Tran, Linh; Chiappini, Barbara; Vanni, Ilaria; Di Bari, Michele A.; Vaccari, Gabriele; Vikøren, Turid; Madslien, Knut Ivar; Våge, Jørn; Spraker, Terry; Mitchell, Gordon; Balachandran, Aru; Baron, Thierry; Casalone, Cristina; Rolandsen, Christer M.; Røed, Knut H.; Agrimi, Umberto; Nonno, Romolo; Benestad, Sylvie L.;

Published:

December 2018

Source:

Emerg Infect Dis. 24(12):2210-2218

Description:

Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in Norway. We report the detection of CWD in 3 moose (Alces alces) in Norway, identified through a ...

File Type:

[PDF - 2.31 MB]