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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="1.3" xml:lang="en" article-type="article-commentary"><?properties manuscript?><processing-meta base-tagset="archiving" mathml-version="3.0" table-model="xhtml" tagset-family="jats"><restricted-by>pmc</restricted-by></processing-meta><front><journal-meta><journal-id journal-id-type="nlm-journal-id">101264860</journal-id><journal-id journal-id-type="pubmed-jr-id">32902</journal-id><journal-id journal-id-type="nlm-ta">Obesity (Silver Spring)</journal-id><journal-id journal-id-type="iso-abbrev">Obesity (Silver Spring)</journal-id><journal-title-group><journal-title>Obesity (Silver Spring, Md.)</journal-title></journal-title-group><issn pub-type="ppub">1930-7381</issn><issn pub-type="epub">1930-739X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">35534772</article-id><article-id pub-id-type="pmc">11179632</article-id><article-id pub-id-type="doi">10.1002/oby.23431</article-id><article-id pub-id-type="manuscript">HHSPA1981247</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Response to &#x0201c;BMI at age 3 years predicts later BMI but age at
adiposity rebound conveys information on BMI pattern-health
association&#x0201d;</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-8014-0289</contrib-id><name><surname>Freedman</surname><given-names>David S.</given-names></name></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-0634-689X</contrib-id><name><surname>Kompaniyets</surname><given-names>Lyudmyla</given-names></name></contrib><aff id="A1">Division of Nutrition, Physical Activity, and Obesity, Centers for
Disease Control and Prevention, Atlanta, Georgia, USA</aff></contrib-group><author-notes><corresp id="CR1">Correspondence: David S. Freedman, Division of Nutrition, Physical
Activity, and Obesity, Centers for Disease Control and Prevention, CDC F107-5,
4770 Buford Highway, Atlanta GA 30341, USA <email>dxf1@cdc.gov</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>19</day><month>4</month><year>2024</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2022</year></pub-date><pub-date pub-type="epub"><day>09</day><month>5</month><year>2022</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>6</month><year>2024</year></pub-date><volume>30</volume><issue>6</issue><fpage>1135</fpage><lpage>1135</lpage><related-article related-article-type="commentary-article" id="ra1" xlink:href="34932881" ext-link-type="pubmed"/><related-article related-article-type="commentary-article" id="ra2" xlink:href="35514267" ext-link-type="pubmed"/></article-meta></front><body><sec id="S1"><title>TO THE EDITOR:</title><p id="P1">We thank Rolland-Cachera et al. for their letter concerning our paper on the
importance of age at the BMI rebound (<xref rid="R1" ref-type="bibr">1</xref>). The
authors agree with two main points of our paper. First, BMI at age 3 years is more
strongly associated with BMI at age 14 years than is the age of the BMI rebound
(second paragraph of their letter). Second, that it is easier to assess BMI at age 3
than to determine the age of the BMI rebound (third paragraph).We agree that there
is an &#x0201c;an infinity of trajectories that can pass through a single [BMI]
point,&#x0201d; but we think the BMI patterns shown for the two children in Figure 1
of their letter may apply to relatively few children. As seen in Figure 3 of our
paper, these BMI patterns were not typically seen among a randomly selected subset
of 16 children. Subsequent analyses of hundreds of children confirmed that very few
showed the BMI patterns of the two children in their Figure 1. As noted in our
article, measurement error and weight variability resulted in most children having a
zigzag pattern, with several BMIs close to the minimum, making it challenging to
determine the age of BMI rebound. The authors also suggest that as compared with the
BMI at age 3 years, an early BMI rebound is more strongly correlated with body
fatness and metabolic complications in later life. We feel there is little evidence
for this. Ylih&#x000e8;rsil&#x000e8; et al. (<xref rid="R2" ref-type="bibr">2</xref>)
did show that a rapid BMI increase before age 2 years and the BMI at age 2 years
among persons born in the 1930s and 1940s were only weakly associated with fat mass
(measured using bioelectrical impedance) among older adults. However, it is not
clear if these findings are relevant to the much heavier contemporary children.
Furthermore, others have shown that rapid weight gain in early life, which may
result in a high BMI at ages 2 or 3 years, is associated with increased levels of
body fatness in later life as mea-sured with more accurate methods. A study (<xref rid="R3" ref-type="bibr">3</xref>) of children born in the mid- 1980s, for
example, found that weight gain between birth and 6 months was associated with
higher levels of fat mass at age 17 years assessed with air-displacement
plethysmography. Another study (<xref rid="R4" ref-type="bibr">4</xref>), based on
children born in the early 2000s, found that weight gain be-tween 3 and 24 months of
age was associated with percentage body fat at ages 6 to 11 years as measured by
dual-energy x-ray absorptiometry. Rapid weight gain in early life also was
associated with reduced insulin sensitivity and increased body fatness among young
adults (<xref rid="R5" ref-type="bibr">5</xref>).Our study showed the importance of
BMI at age 3 years in pre-dicting subsequent BMI levels. The relative importance of
early age at BMI rebound versus BMI at ages 2 or 3 years in subsequent body fatness
and adverse metabolic effects is uncertain.</p></sec></body><back><ack id="S2"><title>ACKNOWLEDGMENTS</title><p id="P2">This report&#x02019;s findings and conclusions are those of the authors and do
not represent the Centers for Disease Control and Prevention&#x02019;s official
position.</p></ack><fn-group><fn fn-type="COI-statement" id="FN1"><p id="P3">CONFLICT OF INTEREST</p><p id="P4">The authors declared no conflict of interest.</p></fn></fn-group><ref-list><title>REFERENCES</title><ref id="R1"><label>1.</label><mixed-citation publication-type="journal"><name><surname>Freedman</surname><given-names>DS</given-names></name>, <name><surname>Goodwin-Davies</surname><given-names>AJ</given-names></name>, <name><surname>Kompaniyets</surname><given-names>L</given-names></name>, <etal/>
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