Emerg Infect DiseidEmerging Infectious Diseases1080-60401080-6059Centers for Disease Control112947372631699Research ArticleEngineering out the risk for infection with urinary catheters.MakiD. G.dgmaki@facstaff.wisc.eduTambyahP. A.University of Wisconsin Medical School, Madison, Wisconsin, USA.Mar-Apr200172342347

Catheter-associated urinary tract infection (CAUTI) is the most common nosocomial infection. Each year, more than 1 million patients in U.S. acute-care hospitals and extended-care facilities acquire such an infection; the risk with short-term catheterization is 5% per day. CAUTI is the second most common cause of nosocomial bloodstream infection, and studies suggest that patients with CAUTI have an increased institutional death rate, unrelated to the development of urosepsis. Novel urinary catheters impregnated with nitrofurazone or minocycline and rifampin or coated with a silver alloy-hydrogel exhibit antiinfective surface activity that significantly reduces the risk of CAUTI for short-term catheterizations not exceeding 2-3 weeks.