Emerg Infect DiseidEmerging Infectious Diseases1080-60401080-6059Centers for Disease Control107561542640842Research ArticleSin nombre virus (SNV) Ig isotype antibody response during acute and convalescent phases of hantavirus pulmonary syndrome.BostikP.WinterJ.KsiazekT. G.RollinP. E.VillingerF.ZakiS. R.PetersC. J.AnsariA. A.Emory University School of Medicine, Atlanta, GA 30322, USA.Mar-Apr200062184187

Serum samples from 22 hantavirus pulmonary syndrome (HPS) patients were tested for Sin Nombre virus (SNV)-reactive antibodies. In the acute phase of HPS, 100% and 67% of the samples tested positive for SNV-specific immunoglobulin (Ig) M and IgA, respectively. Among the virus-specific IgG antibodies, the most prevalent were IgG3 (in 97% of samples), followed by IgG1 (70%), IgG2 (30%), and IgG4 (3%).