Emerg Infect DiseidEmerging Infectious Diseases1080-60401080-6059Centers for Disease Control102218732640686Research ArticleEnteropathogenic E. coli, Salmonella, and Shigella: masters of host cell cytoskeletal exploitation.GoosneyD. L.KnoechelD. G.FinlayB. B.University of British Columbia, Vancouver, British Columbia, Canada.Mar-Apr199952216223

Bacterial pathogens have evolved numerous strategies to exploit their host's cellular processes so that they can survive and persist. Often, a bacterium must adhere very tightly to the cells and mediate its effects extracellularly, or it must find a way to invade the host's cells and survive intracellularly. In either case, the pathogen hijacks the host's cytoskeleton. The cytoskeleton provides a flexible framework for the cell and is involved in mediating numerous cellular functions, from cell shape and structure to programmed cell death. Altering the host cytoskeleton is crucial for mediating pathogen adherence, invasion, and intracellular locomotion. We highlight recent advances in the pathogenesis of enteropathogenic Escherichia coli, Salmonella Typhimurium, and Shigella flexneri. Each illustrates how bacterial pathogens can exert dramatic effects on the host cytoskeleton.